Capivasertib restricts SARS-CoV-2 cellular entry: a potential clinical application for COVID-19

Autor: Zhijian Cao, Xugang Li, Wanhong Liu, Yingliang Wu, Fang Sun, Jean-Marc Sabatier, Cédric Annweiler, Yingqiu Xie, Jiyuan Xu, Chenglin Mu, Hang Fai Kwok

Publikováno v: International Journal of Biological Sciences
International Journal of Biological Sciences, Ivyspring International Publisher, 2021, 17 (9), pp.2348-2355. ⟨10.7150/ijbs.57810⟩
International Journal of Biological Sciences, 2021, 17 (9), pp.2348-2355. ⟨10.7150/ijbs.57810⟩

International audience; Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has led to more than 150 million infections and about 3.1 million deaths up to date. Currently, drugs screene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16bb76c8c1830161edf52674a936828f
https://pubmed.ncbi.nlm.nih.gov/34345206

Fibrinolytic cross-talk: a new mechanism for plasmin formation

Autor: Romaric Lacroix, Tiphaine Dejouvencel, Laurent Plawinski, H. Roger Lijnen, Loïc Doeuvre, Eduardo Anglés-Cano, Françoise Dignat-George

Publikováno v: Blood
Blood, 2010, 115 (10), pp.2048-56. ⟨10.1182/blood-2009-06-228817⟩
Blood; Vol 115
Blood, American Society of Hematology, 2010, 115 (10), pp.2048-56. ⟨10.1182/blood-2009-06-228817⟩

Fibrinolysis and pericellular proteolysis depend on molecular coassembly of plasminogen and its activator on cell, fibrin, or matrix surfaces. We report here the existence of a fibrinolytic cross-talk mechanism bypassing the requirement for their mol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5351dd5b303bfd61de7a8d1914c7089
https://doi.org/10.1182/blood-2009-06-228817

Beta-amyloid peptide stimulates endozepine release in cultured rat astrocytes through activation ofN-formyl peptide receptors

Autor: Hélène Castel, Tursonjan Tokay, Mohamed Amri, Pierrick Gandolfo, Marie Christine Tonon, Hubert Vaudry, Olfa Masmoudi-Kouki, Raya Hachem, Jérôme Leprince, Mickaël Diallo, Laurence Desrues

Publikováno v: Glia
Glia, Wiley, 2008, 56 (13), pp.1380-1389. ⟨10.1002/glia.20705⟩

International audience; Astroglial cells synthesize and release endozepines, a family of neuropeptides derived from diazepam-binding inhibitor (DBI). The authors have recently shown that beta-amyloid peptide (Abeta) stimulates DBI gene expression and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19c50a70eb61a04bcbbe0cad4b81d823
https://doi.org/10.1002/glia.20705

Mutation of the palmitoylation site of estrogen receptor α in vivo reveals tissue-specific roles for membrane versus nuclear actions

Autor: Andrée Krust, Coralie Fontaine, Romain Solinhac, Aurelie Fabre, Pierre Chambon, Lucile Sautier, Sung Hoon Kim, Françoise Lenfant, Daniel Henrion, Emilie Vessieres, Marine Adlanmerini, Pierre Gourdy, Jean-François Arnal, John A. Katzenellenbogen, Anne-Laure Guihot, Philippe Liere, Frédéric Boudou, Philip W. Shaul, Isabelle Raymond-Letron, Anne Abot

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2014, 111 (2), pp.E283-90. ⟨10.1073/pnas.1322057111⟩
Proceedings of the National Academy of Sciences of the United States of America, 2014, 111 (2), pp.E283-90. ⟨10.1073/pnas.1322057111⟩

International audience; Estrogen receptor alpha (ERα) activation functions AF-1 and AF-2 classically mediate gene transcription in response to estradiol (E2). A fraction of ERα is targeted to plasma membrane and elicits membrane-initiated steroid s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99beeb123e919035fbfbd084f68ff5fe
https://doi.org/10.1073/pnas.1322057111

A systems biology approach to the hepatic role of the oxysterol receptor LXR in the regulation of lipogenesis highlights a cross-talk with PPARα

Autor: Stefania Murzilli, Frédéric Lasserre, Jean-Marc A. Lobaccaro, Normand Podechard, Arnaud Polizzi, Justine Bertrand-Michel, Thierry Pineau, Chiara Di Lisio, Alexandra Montagner, Pascal G.P. Martin, Nicolas Loiseau, Hervé Guillou, Simon Ducheix, Simona D'Amore, Aurélien Pommier

Publikováno v: Biochimie
Biochimie, 2013, 95 (3), pp.556-67. ⟨10.1016/j.biochi.2012.09.028⟩
Biochimie, Elsevier, 2013, 95 (3), pp.556-67. ⟨10.1016/j.biochi.2012.09.028⟩

International audience; The Liver X Receptors (LXRs) α and β and the Peroxisome Proliferator-Activated Receptor α (PPARα) are transcription factors that belong to class II nuclear receptors. They drive the expression of genes involved in hepatic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90e080587573de2ce4369df8d0fc4f75
https://www.hal.inserm.fr/inserm-00872582