Zobrazeno 1 - 10
of 16
pro vyhledávání: '"MESH: Quantitative Structure-Activity Relationship"'
Publikováno v:
Environmental Pollution
Environmental Pollution, 2023, 323, pp.121284. ⟨10.1016/j.envpol.2023.121284⟩
Environmental Pollution, 2023, 323, pp.121284. ⟨10.1016/j.envpol.2023.121284⟩
International audience; Mycotoxins and their metabolites are a family of compounds that contains a great diversity of both structure and biological properties. Information on their toxicity is spread within several databases and in scientific literat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7438940b31e9934c3cfb87162b30d533
https://doi.org/10.1016/j.envpol.2023.121284
https://doi.org/10.1016/j.envpol.2023.121284
Autor:
Johannes W. Kruisselbrink, Cleo Tebby, Jacob D. van Klaveren, Marco S. van Lenthe, Alfonso Lampen, Céline Brochot, Marc C. Kennedy, Emiel Rorije, Amélie Crépet, Anna Beronius, Hilko van der Voet, Johanna Zilliacus, Waldo J. de Boer, J.J.B. van den Heuvel, Claudia Luckert, Corinne Sprong
Publikováno v:
Food and Chemical Toxicology, 138
Food and Chemical Toxicology
Food and Chemical Toxicology, Elsevier, 2020, 138, pp.111185. ⟨10.1016/j.fct.2020.111185⟩
Food and Chemical Toxicology, 2020, 138, pp.111185. ⟨10.1016/j.fct.2020.111185⟩
Food and Chemical Toxicology 138 (2020)
Food and Chemical Toxicology
Food and Chemical Toxicology, Elsevier, 2020, 138, pp.111185. ⟨10.1016/j.fct.2020.111185⟩
Food and Chemical Toxicology, 2020, 138, pp.111185. ⟨10.1016/j.fct.2020.111185⟩
Food and Chemical Toxicology 138 (2020)
International audience; A model and data toolbox is presented to assess risks from combined exposure to multiple chemicals using probabilistic methods. The Monte Carlo Risk Assessment (MCRA) toolbox, also known as the EuroMix toolbox, has more than 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b129c002c620caf3cc15fc5e8d6d5fcb
https://pubmed.ncbi.nlm.nih.gov/32058012
https://pubmed.ncbi.nlm.nih.gov/32058012
Publikováno v:
Molecular Informatics
Molecular Informatics, Wiley-VCH, 2018, 37 (9-10), pp.1800059. ⟨10.1002/minf.201800059⟩
Molecular Informatics, 2018, 37 (9-10), pp.1800059. ⟨10.1002/minf.201800059⟩
Molecular Informatics, Wiley-VCH, 2018, 37 (9-10), pp.1800059. ⟨10.1002/minf.201800059⟩
Molecular Informatics, 2018, 37 (9-10), pp.1800059. ⟨10.1002/minf.201800059⟩
International audience; For several decades, hit identification for drug discovery has been facilitated by developments in both fragment-based and high-throughput screening technologies. However, a major bottleneck in drug discovery projects continue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bc4f6ba0760ac897f7ee7430cddd8da
https://hal.archives-ouvertes.fr/hal-02145522
https://hal.archives-ouvertes.fr/hal-02145522
Autor:
Amelot, Aymeric
Publikováno v:
Médecine humaine et pathologie. 2016
Le glioblastome (GBM) est la plus fréquente et la plus agressive des tumeurs gliales du système nerveux central. Le pronostic de ces tumeurs reste dramatique avec une survie médiane variant de 8 à 12 mois. Nous nous sommes attachés au sein d’u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::23088fd51d57b8c87d4c1ecbd880530e
https://dumas.ccsd.cnrs.fr/dumas-01664064
https://dumas.ccsd.cnrs.fr/dumas-01664064
Autor:
Mohcine Elmessaoudi-Idrissi, Arnaud Blondel, Anass Kettani, Marc P. Windisch, Sayeh Ezzikouri, Soumaya Benjelloun
Publikováno v:
Current Medicinal Chemistry
Current Medicinal Chemistry, Bentham Science Publishers, 2018, 25 (23), pp.2709-2721. ⟨10.2174/0929867325666180221141451⟩
Current Medicinal Chemistry, 2018, 25 (23), pp.2709-2721. ⟨10.2174/0929867325666180221141451⟩
Current Medicinal Chemistry, Bentham Science Publishers, 2018, 25 (23), pp.2709-2721. ⟨10.2174/0929867325666180221141451⟩
Current Medicinal Chemistry, 2018, 25 (23), pp.2709-2721. ⟨10.2174/0929867325666180221141451⟩
Hepatitis B Virus (HBV) is a major global health burden. Interferon alpha and nucleos(t)ide analogues are currently the standard-of-care for chronic HBV infection. However, these antiviral agents have limited efficacy and do not result in a sustained
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5619f110d1c8caa76ef3dfca0e7a17e0
https://pubmed.ncbi.nlm.nih.gov/29473495
https://pubmed.ncbi.nlm.nih.gov/29473495
Autor:
Céline Gheeraert, Alexandre Berthier, Rémy Le Guével, Gilles Salbert, Patrick Balaguer, Philippe Lefebvre, Bart Staels, Abdel Boulahtouf, Frédérik Oger
Publikováno v:
Toxicological Sciences
Toxicological Sciences, Oxford University Press (OUP), 2012, 127 (1), pp.225-35. ⟨10.1093/toxsci/kfs073⟩
Toxicological Sciences, 2012, 127 (1), pp.225-35. ⟨10.1093/toxsci/kfs073⟩
Toxicological Sciences, Oxford University Press (OUP), 2012, 127 (1), pp.225-35. ⟨10.1093/toxsci/kfs073⟩
Toxicological Sciences, 2012, 127 (1), pp.225-35. ⟨10.1093/toxsci/kfs073⟩
International audience; The human pregnane X receptor (PXR) is a ligand-regulated transcription factor belonging to the nuclear receptor superfamily. PXR is activated by a large, structurally diverse, set of endogenous and xenobiotic compounds and co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::419536c58bd00f433a1d7483ea49fe10
https://doi.org/10.1093/toxsci/kfs073
https://doi.org/10.1093/toxsci/kfs073
Autor:
Alberto Massarotti, Charles Thomas, Johan Auwerx, Emiliano Rosatelli, Antonio Macchiarulo, Paola Sabbatini, Roberto Nuti, Kristina Schoonjans, Antimo Gioiello, Roberto Pellicciari
Publikováno v:
Journal of Chemical Information and Modeling
Journal of Chemical Information and Modeling, 2008, 48 (9), pp.1792-801. ⟨10.1021/ci800196h⟩
Journal of Chemical Information and Modeling, American Chemical Society, 2008, 48 (9), pp.1792-801. ⟨10.1021/ci800196h⟩
Journal of Chemical Information and Modeling, 2008, 48 (9), pp.1792-801. ⟨10.1021/ci800196h⟩
Journal of Chemical Information and Modeling, American Chemical Society, 2008, 48 (9), pp.1792-801. ⟨10.1021/ci800196h⟩
International audience; Bile acids regulate nongenomic actions through the activation of TGR5, a membrane receptor that is G protein-coupled to the induction of adenylate cyclase. In this work, a training set of 43 bile acid derivatives is used to de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c330b74dcafd574c827a05c78420141
https://doi.org/10.1021/ci800196h
https://doi.org/10.1021/ci800196h
Autor:
Anita Solhaug, Nana Asare, Dominique Lagadic-Gossmann, Nina E. Landvik, Morgane Gorria, Volker M. Arlt, Jørn A. Holme
Publikováno v:
Toxicology
Toxicology, Elsevier, 2007, 231 (2-3), pp.159-74. ⟨10.1016/j.tox.2006.12.009⟩
Toxicology, 2007, 231 (2-3), pp.159-74. ⟨10.1016/j.tox.2006.12.009⟩
Toxicology, Elsevier, 2007, 231 (2-3), pp.159-74. ⟨10.1016/j.tox.2006.12.009⟩
Toxicology, 2007, 231 (2-3), pp.159-74. ⟨10.1016/j.tox.2006.12.009⟩
Nitrated-polycyclic aromatic hydrocarbons (nitro-PAHs) and diesel exhaust particle extracts (DEPE) induced apoptosis in Hepa1c1c7 cells with the following potency: 1,3-dinitropyrene (1,3-DNP)>1-nitropyrene (1-NP) >> DEPE >> 1,8-dinitropyrene (1,8-DNP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e6a6689e4642d9a81a4d7d5b9e91f59
https://doi.org/10.1016/j.tox.2006.12.009
https://doi.org/10.1016/j.tox.2006.12.009
Publikováno v:
Biochemistry
Biochemistry, American Chemical Society, 2005, 44 (44), pp.14409-14418. ⟨10.1021/bi050986v⟩
Biochemistry, American Chemical Society, 2005, 44, pp.14409-18
Biochemistry, American Chemical Society, 2005, 44 (44), pp.14409-18. ⟨10.1021/bi050986v⟩
Biochemistry, American Chemical Society, 2005, 44 (44), pp.14409-14418. ⟨10.1021/bi050986v⟩
Biochemistry, American Chemical Society, 2005, 44, pp.14409-18
Biochemistry, American Chemical Society, 2005, 44 (44), pp.14409-18. ⟨10.1021/bi050986v⟩
0006-2960 (Print) Journal Article; The relationship between three environmental factors (ionic strength, pH, and temperature) and antigen-antibody binding kinetics was investigated using QSAR (quantitative structure-activity relationship) and molecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ba78f2b5992dd255cd125756e2ba4f6
https://doi.org/10.1021/bi050986v
https://doi.org/10.1021/bi050986v
Autor:
Béla Kocsis, Orsolya Bouquet, Tristan Rossignol, Ferenc Kilár, Peter B. Jakus, Kshitij Rajbhandari, Laszlo Prokai, Tamás Lóránd, Ildikó Kustos, Christophe d'Enfert, Adrien Nyul
Publikováno v:
PLoS ONE
PLoS ONE, Public Library of Science, 2013, 8 (4), pp.e62142. ⟨10.1371/journal.pone.0062142⟩
PLoS ONE, 2013, 8 (4), pp.e62142. ⟨10.1371/journal.pone.0062142⟩
PLoS ONE, Vol 8, Iss 4, p e62142 (2013)
Plos One 4 (8), 1-11. (2013)
PLoS ONE, Public Library of Science, 2013, 8 (4), pp.e62142. ⟨10.1371/journal.pone.0062142⟩
PLoS ONE, 2013, 8 (4), pp.e62142. ⟨10.1371/journal.pone.0062142⟩
PLoS ONE, Vol 8, Iss 4, p e62142 (2013)
Plos One 4 (8), 1-11. (2013)
International audience; We investigated the antifungal activity of fused Mannich ketone (FMK) congeners and two of their aminoalcohol derivatives. In particular, FMKs with five-membered saturated rings were shown to have minimum inhibitory concentrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2324889c22046fd675247f7407014aee
https://hal-pasteur.archives-ouvertes.fr/pasteur-01522885
https://hal-pasteur.archives-ouvertes.fr/pasteur-01522885