Výsledky vyhledávání - "MESH: Pyrrolidinones"

mGlu1 receptor canonical signaling pathway contributes to the opening of the orphan GluD2 receptor

Autor: Selma Dadak, Elise Goyet, Nathalie Bouquier, Carole Levenes, Laurent Fagni, Julie Perroy

Publikováno v: Neuropharmacology
Neuropharmacology, Elsevier, 2017, 115, pp.92-99. ⟨10.1016/j.neuropharm.2016.06.001⟩

International audience; The orphan Glutamate receptor Delta2 (GluD2) intrinsic ion channel activity is indirectly triggered by glutamate through stimulation of the metabotropic glutamate receptor 1 (mGlu1), in cerebellar Purkinje cells. However, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e81109bd037540b03d7a019764b76ad
https://hal.archives-ouvertes.fr/hal-03109591

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Ritonavir-boosted darunavir combined with raltegravir or tenofovir–emtricitabine in antiretroviral-naive adults infected with HIV-1: 96 week results from the NEAT001/ANRS143 randomised non-inferiority trial

Publikováno v: The Lancet Neurology
The Lancet Neurology, Elsevier, 2014, 384 (9958), pp.1942-51
Lancet, 384(9958), 1942-1951. Elsevier Limited
The Lancet Neurology, 2014, 384 (9958), pp.1942-51

Summary Background Standard first-line antiretroviral therapy for HIV-1 infection includes two nucleoside or nucleotide reverse transcriptase inhibitors (NtRTIs), but these drugs have limitations. We assessed the 96 week efficacy and safety of an NtR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f1ac1bb7a3ea99403d35ff15e3a0920
https://doi.org/10.1016/s0140-6736(14)61170-3

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Virological and immunological response in HIV-1-infected patients with multiple treatment failures receiving raltegravir and optimized background therapy, ANRS CO3 Aquitaine Cohort

Autor: Linda, Wittkop, Dominique, Breilh, Daniel, Da Silva, Pierre, Duffau, Patrick, Mercié, Isabelle, Raymond, Guerric, Anies, Hervé, Fleury, Marie-Claude, Saux, Francois, Dabis, Catherine, Fagard, Rodolphe, Thiébaut, Bernard, Masquelier, Isabelle, Pellegrin, D, Touchard

Publikováno v: Journal of Antimicrobial Chemotherapy
Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), 2009, 63 (6), pp.1251-5. ⟨10.1093/jac/dkp114⟩

International audience; BACKGROUND: The efficacy of raltegravir plus optimized background therapy (OBT) has been demonstrated for antiretroviral (ARV)-experienced HIV-1-infected patients in randomized clinical trials. We studied viro-immunological re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2c55f09244fee519ba313c02f1dea6e
https://doi.org/10.1093/jac/dkp114

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Nevirapine-raltegravir combination, an NRTI and PI/r sparing regimen, as maintenance antiretroviral therapy in virologically suppressed HIV-1-infected patients

Autor: Elisabeth André-Garnier, Virginie Ferré, Dominique Bettinger, Catherine Chirouze, Bruno Hoen, Gilles Peytavin, François Raffi, Patrice Muret, Clotilde Allavena, Véronique Reliquet

Publikováno v: Antiviral Therapy
Antiviral Therapy, International Medical Press, 2013, 19 (1), pp.117-23
Antiviral Therapy, International Medical Press, 2013, epub ahead of print. ⟨10.3851/IMP2691⟩
Antiviral Therapy, International Medical Press, 2013, epub ahead of print. 〈10.3851/IMP2691〉

Background Nucleoside reverse transcriptase inhibitor (NRTI) and protease inhibitor (PI)/ritonavir sparing regimens may be useful to some HIV-infected patients. Nevirapine (NVP) and raltegravir (RAL) are both potent antiretrovirals with good long-ter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5015a91c86c785392cc0402e7078e12
https://pubmed.ncbi.nlm.nih.gov/24145365

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Impact of the HIV integrase genetic context on the phenotypic expression and in vivo emergence of raltegravir resistance mutations

Autor: Thi Thu Nga Nguyen, Sylvie Rato, François Clavel, Jean-Michel Molina, Fabrizio Mammano, Constance Delaugerre

Publikováno v: Journal of Antimicrobial Chemotherapy
Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), 2014, 70 (3), pp.731-738. ⟨10.1093/jac/dku424⟩

International audience; Objectives: HIV resistance to the integrase inhibitor raltegravir in treated patients is characterized by distinct resistance pathways. We hypothesize that differences in the in vivo dynamics of HIV resistance to raltegravir a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e4a050202ba2a52feac5f518d0658aa
https://www.hal.inserm.fr/inserm-03451969

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Long-term efficacy and safety of raltegravir, etravirine, and darunavir/ritonavir in treatment-experienced patients: week 96 results from the ANRS 139 TRIO trial

Autor: Fagard, Catherine, Colin, Céline, Charpentier, Charlotte, Rami, Agathe, Jacomet, Christine, Yeni, Patrick, Vittecoq, Daniel, Katlama, Christine, Molina, Jean-Michel, Descamps, Diane, Chêne, Geneviève, Yazdanpanah, Yazdan, Michelet, Christian

Publikováno v: Journal of Acquired Immune Deficiency Syndromes
Journal of Acquired Immune Deficiency Syndromes, Lippincott, Williams & Wilkins, 2012, 59 (5), pp.489-93. ⟨10.1097/QAI.0b013e31824bb720⟩
Journal of Acquired Immune Deficiency Syndromes-JAIDS
Journal of Acquired Immune Deficiency Syndromes-JAIDS, 2012, 59 (5), pp.489-93. ⟨10.1097/QAI.0b013e31824bb720⟩

International audience; Among 103 patients with multidrug-resistant HIV who initiated raltegravir, etravirine, and darunavir/ritonavir-containing regimen in the ANRS 139 TRIO trial, 100 participated in extended follow-up and continued study treatment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::135ff9781de79fa9308a620e8a93fc11
https://hal.archives-ouvertes.fr/hal-00875207

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HIV-1 resistance patterns to integrase inhibitors in antiretroviral-experienced patients with virological failure on raltegravir-containing regimens

Autor: Dominique Breilh, Kurt Van Baelen, Sandrine Reigadas, Philippe Morlat, Liesbeth Van Wesenbeeck, Daniel da Silva, Linda Wittkop, Hervé Fleury, Guerric Anies, Didier Neau, Bernard Masquelier, Michel Dupon

Publikováno v: Journal of Antimicrobial Chemotherapy
Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), 2010, 65 (6), pp.1262-9. ⟨10.1093/jac/dkq099⟩

International audience; BACKGROUND: Our aim was to study the in vivo viral genetic pathways for resistance to raltegravir, in antiretroviral-experienced patients with virological failure (VF) on raltegravir-containing regimens. METHODS: We set up a p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4df3fdb0ad2a4869d43c57e4f06ca006
https://hal.archives-ouvertes.fr/hal-00594696

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Evolution of 2-long terminal repeat (2-LTR) episomal HIV-1 DNA in raltegravir-treated patients and in in vitro infected cells

Autor: Guerric Anies, Bernard Masquelier, Linda Wittkop, Rodolphe Thiébaut, Sandrine Reigadas, Marie-Line Andreola, Patricia Recordon-Pinson, Ophélie Cosnefroy, Hervé Fleury

Publikováno v: Journal of Antimicrobial Chemotherapy
Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), 2010, 65 (3), pp.434-7. ⟨10.1093/jac/dkp473⟩
Journal of Antimicrobial Chemotherapy; Vol 65

International audience; OBJECTIVES: Our aim was to analyse the evolution of HIV-1 2-long terminal repeat (2-LTR) circular DNA in vitro and ex vivo in the presence of raltegravir. PATIENTS AND METHODS: Twenty-five patients starting a raltegravir-based

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84fe74e611505667a6897dd74e95b6f8
https://pubmed.ncbi.nlm.nih.gov/20051476

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Virological and immunological response in HIV-1-infected patients with multiple treatment failures receiving raltegravir and optimized background therapy, ANRS CO3 Aquitaine Cohort

Autor: Wittkop, Linda, Breilh, Dominique, Da-Silva, Daniel, Duffau, Pierre, Mercié, Patrick, Raymond, Isabelle, Anies, Guerric, Fleury, Hervé, Saux, Marie-Claude, Dabis, François, Fagard, Catherine, Thiébaut, Rodolphe, Masquelier, Bernard, Pellegrin, Isabelle

Publikováno v: Journal of Antimicrobial Chemotherapy
Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), 2009, 63 (6), pp.1251-5. ⟨10.1093/jac/dkp114⟩

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1398::da94e64550f7190af06a7f9b6d09de92
https://www.hal.inserm.fr/inserm-00372614/file/inserm-00372614_edited.pdf

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The transfer of VLDL-associated phospholipids to activated platelets depends upon cytosolic phospholipase A2 activity

Autor: Ibrahim, Salam, Calzada, Catherine, Pruneta-Deloche, Valérie, Lagarde, Michel, Ponsin, Gabriel

Publikováno v: Journal of Lipid Research 7 (48), 1533-8. (2007)
The Journal of Lipid Research
The Journal of Lipid Research, 2007, 48 (7), pp.1533-8. ⟨10.1194/jlr.M600480-JLR200⟩
Journal of Lipid Research
Journal of Lipid Research, American Society for Biochemistry and Molecular Biology, 2007, 48 (7), pp.1533-8. ⟨10.1194/jlr.M600480-JLR200⟩

International audience; We previously reported that VLDL could transfer phospholipids (PLs) to activated platelets. To identify the metabolic pathway involved in this process, the transfer of radiolabeled PLs from VLDL (200 microM PL) to platelets (2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::e3f3c4e517138f5397c4c5996da65d1c
http://prodinra.inra.fr/record/250834

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