Výsledky vyhledávání - "MESH: Pyridazines"

Dual therapy combining raltegravir with etravirine maintains a high level of viral suppression over 96 weeks in long-term experienced HIV-infected individuals over 45 years on a PI-based regimen: results from the Phase II ANRS 163 ETRAL study-authors' response

Autor: Christine Katlama, Lambert Assoumou, Marc-Antoine Valantin, Cathia Soulié, Esteban Martinez, Lydie Béniguel, Olivier Bouchaud, François Raffi, Jean-Michel Molina, Soraya Fellahi, Gilles Peytavin, Anne-Geneviève Marcelin, Sami Kolta, Jacqueline Capeau, Severine Gibowski, Fanny Cardon, Jacques Reynes, Dominique Costagliola

Publikováno v: Journal of Antimicrobial Chemotherapy
Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), 2020, 75 (12), pp.3699-3700. ⟨10.1093/jac/dkaa341⟩

International audience

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b9eb3a74b0e5bc9277900e64e047518
https://pubmed.ncbi.nlm.nih.gov/32285104

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Ultra-rapid axon-axon ephaptic inhibition of cerebellar Purkinje cells by the pinceau

Autor: Boris Barbour, Antonin Blot

Publikováno v: Nature Neuroscience
Nature Neuroscience, Nature Publishing Group, 2014, 17 (2), pp.289-295. ⟨10.1038/nn.3624⟩
Nature Neuroscience, 2014, 17 (2), pp.289-295. ⟨10.1038/nn.3624⟩

International audience; Excitatory synaptic activity in the brain is shaped and balanced by inhibition. Because inhibition cannot propagate, it is often recruited with a synaptic delay by incoming excitation. Cerebellar Purkinje cells are driven by l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a88c7d3a5ca89debf6825926b95424d
https://pubmed.ncbi.nlm.nih.gov/24413696

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Long-term efficacy and safety of raltegravir, etravirine, and darunavir/ritonavir in treatment-experienced patients: week 96 results from the ANRS 139 TRIO trial

Autor: Fagard, Catherine, Colin, Céline, Charpentier, Charlotte, Rami, Agathe, Jacomet, Christine, Yeni, Patrick, Vittecoq, Daniel, Katlama, Christine, Molina, Jean-Michel, Descamps, Diane, Chêne, Geneviève, Yazdanpanah, Yazdan, Michelet, Christian

Publikováno v: Journal of Acquired Immune Deficiency Syndromes
Journal of Acquired Immune Deficiency Syndromes, Lippincott, Williams & Wilkins, 2012, 59 (5), pp.489-93. ⟨10.1097/QAI.0b013e31824bb720⟩
Journal of Acquired Immune Deficiency Syndromes-JAIDS
Journal of Acquired Immune Deficiency Syndromes-JAIDS, 2012, 59 (5), pp.489-93. ⟨10.1097/QAI.0b013e31824bb720⟩

International audience; Among 103 patients with multidrug-resistant HIV who initiated raltegravir, etravirine, and darunavir/ritonavir-containing regimen in the ANRS 139 TRIO trial, 100 participated in extended follow-up and continued study treatment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::135ff9781de79fa9308a620e8a93fc11
https://hal.archives-ouvertes.fr/hal-00875207

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Levosimedan improves hemodynamics functions without sympathetic activation in severe heart failure patients: direct evidence from sympathetic neural recording

Autor: Marc Labrunee, Nicolas Franchitto, Michel Galinier, Atul Pathak, Jean-Michel Senard, Charlotte Trouillet, Fabien Despas

Publikováno v: Acute Cardiac Care
Acute Cardiac Care, 2010, 12 (1), pp.25-30. ⟨10.3109/17482940903434077⟩
Acute Cardiac Care, Taylor & Francis, 2010, 12 (1), pp.25-30. ⟨10.3109/17482940903434077⟩

International audience; Levosimendan is a new inodilatory agent with calcium sensitizing activity. A major concern regarding the use of inotropic agent in heart failure is their effect on the sympathetic tone. This effect could explain increase in sh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0e3b4f152fd37a0de64331ae324d906
https://www.hal.inserm.fr/inserm-00504954

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Depolarization-induced release of endocannabinoids by murine dorsal motor nucleus of the vagus nerve neurons differentially regulates inhibitory and excitatory neurotransmission

Autor: André Jean, Bruno Lebrun, Jérôme Trouslard, Julien Roux, Nicolas Wanaverbecq

Publikováno v: Neuropharmacology
Neuropharmacology, 2009, 56 (8), pp.1106-15. ⟨10.1016/j.neuropharm.2009.03.009⟩
Neuropharmacology, Elsevier, 2009, 56 (8), pp.1106-15. ⟨10.1016/j.neuropharm.2009.03.009⟩

International audience; Numerous studies, focused on the hypothalamus, have recently implicated endocannabinoids (EC) as orexigenic factors in the central control of food intake. However, the EC system is also highly expressed in the hindbrain autono

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::413864ac0e119003d01823190d898cf0
https://hal.science/hal-00417358

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Antagonist properties of arylaminopyridazine GABA derivatives at the Ascaris muscle GABA receptor

Autor: Duittoz, Anne, Martin, R

Publikováno v: Journal of Experimental Biology
Journal of Experimental Biology, The Company of Biologists, 1991, 159, pp.149-64

1. In a previous study, it was shown that the potency order for two arylamino-pyridazine derivatives, SR95531 and SR95103, was different in Ascaris suum when compared to vertebrate preparations. SR95531, the most potent analogue at the vertebrate GAB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd7293b49c588d1218d98a288ce15db8
https://doi.org/10.1242/jeb.159.1.149

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Identification of nonpeptide CCR5 receptor agonists by structure-based virtual screening

Autor: Jean-Yves Springael, Didier Rognan, Marc Parmentier, Jean-Luc Galzi, Esther Kellenberger, Muriel Hachet-Haas

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2007, 50 (6), pp.1294-303. ⟨10.1021/jm061389p⟩
Journal of Medicinal Chemistry, American Chemical Society, 2007, 50 (6), pp.1294-1303. ⟨10.1021/jm061389p⟩

International audience; A three-dimensional model of the chemokine receptor CCR5 has been built to fulfill structural peculiarities of its alpha-helix bundle and to distinguish known CCR5 antagonists from randomly chosen drug-like decoys. In silico s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d21f4499cac940ab5b1c6811ffecbb2
https://pubmed.ncbi.nlm.nih.gov/17311371

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