Zobrazeno 1 - 10
of 25
pro vyhledávání: '"MESH: Purines"'
Autor:
Roberto Farina Almeida, Yasmine Nonose, Marcelo Ganzella, Samanta Oliveira Loureiro, Andréia Rocha, Daniele Guilhermano Machado, Bruna Bellaver, Fernanda Urruth Fontella, Douglas T. Leffa, Letícia Ferreira Pettenuzzo, Gianina Teribele Venturin, Samuel Greggio, Jaderson Costa da Costa, Eduardo R. Zimmer, Elaine Elisabetsky, Diogo O. Souza
Publikováno v:
Frontiers in Psychiatry
Repositório Institucional da UFRGS
Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
Frontiers in Psychiatry, Vol 12 (2021)
Repositório Institucional da UFRGS
Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
Frontiers in Psychiatry, Vol 12 (2021)
Major depressive disorder (MDD) leads to pervasive changes in the health of afflicted patients. Despite advances in the understanding of MDD and its treatment, profound innovation is needed to develop fast-onset antidepressants with higher effectiven
Publikováno v:
Chemistry-A European Journal
Chemistry-A European Journal, Wiley-VCH Verlag, 2013, 19 (50), pp.16916-22. ⟨10.1002/chem.201303690⟩
Chemistry-A European Journal, Wiley-VCH Verlag, 2013, 19 (50), pp.16916-22. ⟨10.1002/chem.201303690⟩
OH (2:1 v/v), and sulfu-ric acid. In the case of chondrites, achondrites, and stony-iron meteorites, the samples were also pyrolyzed at 6008C.After the treatment, the powders did not release any traceof organic substances. The synthesis of large numb
Autor:
Yvan Boublik, Mehdi Chenik, Hechmi Louzir, Yosser Ben Achour-Chenik, Ahlem Aamouri, Inès Lakhal-Naouar, Abdellatif Fattoum, Mounira Meddeb
Publikováno v:
Biochemical and Biophysical Research Communications
Biochemical and Biophysical Research Communications, Elsevier, 2008, 375 (1), pp.54-8. ⟨10.1016/j.bbrc.2008.07.099⟩
Biochemical and Biophysical Research Communications, Elsevier, 2008, 375 (1), pp.54-8. ⟨10.1016/j.bbrc.2008.07.099⟩
International audience; We report the characterization of a new Leishmania major gene, lmaj3'nt/nu, encoding a 382 amino acids protein, Lmaj3'NT/NU, that belongs to the 3'nucleotidase/nuclease family. Interestingly, sequence and phylogenetic analysis
Autor:
STEPHANE NANCEY, Francois MION, Nathalie Ganne-Carrié, Dany GARGOT, ANTOINE CORTOT, Laurent Siproudhis, Bernard FLOURIE, ROBERT BENAMOUZIG, Tabassome SIMON, Frederic Gottrand, Guillaume Savoye, Gerard Thiefin, Fabrice Carrat, Jean-Pierre Hugot, Pierre DESREUMAUX, Laurent Peyrin-biroulet, Laurent Michaud, Christos CHRISTIDIS, Olivier Hermine
Publikováno v:
The Lancet
The Lancet, Elsevier, 2009, 374 (9701), pp.1617-25. 〈10.1016/S0140-6736(09)61302-7〉
The Lancet, Elsevier, 2009, 374 (9701), pp.1617-25. ⟨10.1016/S0140-6736(09)61302-7⟩
The Lancet, 2009, 374 (9701), pp.1617-25. ⟨10.1016/S0140-6736(09)61302-7⟩
The Lancet, Elsevier, 2009, 374 (9701), pp.1617-25. 〈10.1016/S0140-6736(09)61302-7〉
The Lancet, Elsevier, 2009, 374 (9701), pp.1617-25. ⟨10.1016/S0140-6736(09)61302-7⟩
The Lancet, 2009, 374 (9701), pp.1617-25. ⟨10.1016/S0140-6736(09)61302-7⟩
International audience; BACKGROUND: Reports of an increased risk of lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease are controversial. We assessed this risk in a prospective observational cohort study. M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5099a913a752bf9f0fcafbc176727015
https://hal.archives-ouvertes.fr/hal-00466312
https://hal.archives-ouvertes.fr/hal-00466312
Autor:
Jean-Patrick Joly, Maria Duca, Patrick Eldin, Laurence Briant, Guillaume Mata, Rachid Benhida, Fabien Fontaine-Vive
Publikováno v:
Chemistry-A European Journal
Chemistry-A European Journal, Wiley-VCH Verlag, 2014, 20 (7), pp.2071-9. ⟨10.1002/chem.201303664⟩
Chemistry-A European Journal, Wiley-VCH Verlag, 2014, 20 (7), pp.2071-2079. ⟨10.1002/chem.201303664⟩
Chemistry-A European Journal, Wiley-VCH Verlag, 2014, 20 (7), pp.2071-9. ⟨10.1002/chem.201303664⟩
Chemistry-A European Journal, Wiley-VCH Verlag, 2014, 20 (7), pp.2071-2079. ⟨10.1002/chem.201303664⟩
International audience; The human immunodeficiency virus type-1 (HIV-1) Tat protein stimulates transcriptional elongation. Tat is involved in the transcription machinery by binding to the transactivation response region (TAR) RNA stem-loop structure,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2304103832e98edfa63bdbc3866bdb8e
https://hal.archives-ouvertes.fr/hal-01131870
https://hal.archives-ouvertes.fr/hal-01131870
Autor:
Laurent Meijer, Gordon B. Mills, Khandan Keyomarsi, Donald H. Lambert, Laura A. Lambert, Na Qiao, Kelly K. Hunt
Publikováno v:
Cancer Research
Cancer Research, 2008, 68 (19), pp.7966-74. ⟨10.1158/0008-5472.CAN-08-1333⟩
Cancer Research, American Association for Cancer Research, 2008, 68 (19), pp.7966-74. ⟨10.1158/0008-5472.CAN-08-1333⟩
Cancer Research, American Association for Cancer Research, 2008, 68 (19), pp.7966-74. 〈10.1158/0008-5472.CAN-08-1333〉
Cancer Research, 2008, 68 (19), pp.7966-74. ⟨10.1158/0008-5472.CAN-08-1333⟩
Cancer Research, American Association for Cancer Research, 2008, 68 (19), pp.7966-74. ⟨10.1158/0008-5472.CAN-08-1333⟩
Cancer Research, American Association for Cancer Research, 2008, 68 (19), pp.7966-74. 〈10.1158/0008-5472.CAN-08-1333〉
Doxorubicin is a genotoxic chemotherapy agent used in treatment of a wide variety of cancers. Significant clinical side effects, including cardiac toxicity and myelosuppression, severely limit the therapeutic index of this commonly used agent and met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::264c11b00fcf711983860e67cc552593
https://europepmc.org/articles/PMC2561224/
https://europepmc.org/articles/PMC2561224/
Publikováno v:
Cell Cycle
Cell Cycle, Taylor & Francis, 2008, 7 (12), pp.1702-8
Cell Cycle, Taylor & Francis, 2008, 7 (12), pp.1702-8. ⟨10.4161/cc.7.12.6101⟩
Cell Cycle, 2008, 7 (12), pp.1702-8. ⟨10.4161/cc.7.12.6101⟩
Cell Cycle, Taylor & Francis, 2008, 7 (12), pp.1702-8
Cell Cycle, Taylor & Francis, 2008, 7 (12), pp.1702-8. ⟨10.4161/cc.7.12.6101⟩
Cell Cycle, 2008, 7 (12), pp.1702-8. ⟨10.4161/cc.7.12.6101⟩
International audience; Cyclin-dependent kinases are highly conserved among all eukaryotes, and have essential roles in the cell cycle. However, these roles are still only poorly understood at a molecular level, partly due to the functional redundanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e374d3e0756e8e0bd56b4a1ce158bf8
http://www.hal.inserm.fr/inserm-00723361/file/Cell_cycle_EV_Krasinska_Cot_Fisher.pdf
http://www.hal.inserm.fr/inserm-00723361/file/Cell_cycle_EV_Krasinska_Cot_Fisher.pdf
Autor:
Richard Delarue, Mathilde Hunault-Berger, Olivier Tournilhac, Arnaud Jaccard, Philippe Rodon, Pierre Morel, Marc Bernard, Arnaud Hot, Mohamed Hamidou, Benjamin Terrier, Fadi Fakhouri, Olivier Gisserot, Jean-Paul Fermand, Bernard Grosbois, Caroline Elie, Jacques Dantal, Véronique Leblond, Valérie Coiteux, Jean-Luc Harousseau
Publikováno v:
Medicine
Medicine, Lippincott, Williams & Wilkins, 2008, 87 (2), pp.99-109. ⟨10.1097/MD.0b13e31816c43b6⟩
Medicine, Lippincott, Williams & Wilkins, 2008, 87 (2), pp.99-109. 〈10.1097/MD.0b13e31816c43b6〉
Medicine, Lippincott, Williams & Wilkins, 2008, 87 (2), pp.99-109. ⟨10.1097/MD.0b13e31816c43b6⟩
Medicine, Lippincott, Williams & Wilkins, 2008, 87 (2), pp.99-109. 〈10.1097/MD.0b13e31816c43b6〉
International audience; Immunoglobulin M (IgM)-related amyloidosis remains a rare and little-known complication of monoclonal IgM-associated disorders. We sought to determine the clinical and laboratory presentation, response to treatment, and outcom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18a0e62ba220e608494d399d21e88005
https://hal.archives-ouvertes.fr/hal-00453185
https://hal.archives-ouvertes.fr/hal-00453185
Autor:
Mark Levasseur, Alex McDougall
Publikováno v:
Development (Cambridge, England)
Development (Cambridge, England), Company of Biologists, 2000, 127 (3), pp.631-41
Europe PubMed Central
Development (Cambridge, England), Company of Biologists, 2000, 127 (3), pp.631-41
Europe PubMed Central
The generation of calcium oscillations at fertilisation and during mitosis appears to be controlled by the cell cycle machinery. For example, the calcium oscillations in oocytes and embryos occur during metaphase and terminate upon entry into interph
Autor:
Iulia Blesneac, Stéphanie Ravaud, Eva Pebay-Peyroula, Manuela Zoonens, Paul Machillot, Michel Vivaudou, Sandrine Masscheylen, Bruno Miroux
Publikováno v:
Biophysics of structure and mechanism
Biophysics of structure and mechanism, Springer-Verlag, 2012, 41 (8), pp.675-9
Biophysics of structure and mechanism, 2012, 41 (8), pp.675-9
HAL
European Biophysics Journal; Vol 41
Biophysics of structure and mechanism, Springer-Verlag, 2012, 41 (8), pp.675-9
Biophysics of structure and mechanism, 2012, 41 (8), pp.675-9
HAL
European Biophysics Journal; Vol 41
International audience; The uncoupling protein 1 (UCP1) is a mitochondrial protein that carries protons across the inner mitochondrial membrane. It has an important role in non-shivering thermogenesis, and recent evidence suggests its role in human a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd7d2f9aea7cf2c614f8c24b512c711d
https://hal.univ-grenoble-alpes.fr/hal-01179678
https://hal.univ-grenoble-alpes.fr/hal-01179678