Výsledky vyhledávání - "MESH: Proto-Oncogene Proteins/metabolism"

TET2-mediated 5-hydroxymethylcytosine induces genetic instability and mutagenesis

Autor: Lise Secardin, William Vainchenker, Olivier Bernard, Alexander A. Ishchenko, Murat Saparbaev, Emna Mahfoudhi, Philippe Rameau, Véronique Della Valle, Ibtissam Talhaoui, Isabelle Plo, Xenia Cabagnols, Salem Abbes

Publikováno v: DNA Repair
DNA Repair, Elsevier, 2016, 43, pp.78-88. <10.1016/j.dnarep.2016.05.031>
DNA Repair, Elsevier, 2016, 43, pp.78-88. ⟨10.1016/j.dnarep.2016.05.031⟩
DNA Repair, 2016, 43, pp.78-88. ⟨10.1016/j.dnarep.2016.05.031⟩

International audience; The family of Ten-Eleven Translocation (TET) proteins is implicated in the process of active DNA demethy-lation and thus in epigenetic regulation. TET 1, 2 and 3 proteins are oxygenases that can hydroxylate 5-methylcytosine (5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c62d059a77d68707fe91ef4741f2a19f
https://doi.org/10.1016/j.dnarep.2016.05.031

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Zika Virus Disrupts Phospho-TBK1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial Glia

Publikováno v: Cell Reports
Cell Reports, Elsevier Inc, 2016, 16 (10), pp.2576-2592. ⟨10.1016/j.celrep.2016.08.038⟩
Cell Reports, 2016, 16 (10), pp.2576-2592. ⟨10.1016/j.celrep.2016.08.038⟩
Cell Reports, Vol 16, Iss 10, Pp 2576-2592 (2016)

SummaryThe mechanisms underlying Zika virus (ZIKV)-related microcephaly and other neurodevelopment defects remain poorly understood. Here, we describe the derivation and characterization, including single-cell RNA-seq, of neocortical and spinal cord

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8842a91c108e53c206bfa4ca694b4d28
https://hal-pasteur.archives-ouvertes.fr/pasteur-01739212

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Deregulation of anti-Mullerian hormone/BMP and transforming growth factor- pathways in Leydig cell lesions developed in male heterozygous multiple endocrine neoplasia type 1 mutant mice

Autor: Séverine Mazaud Guittot, Sandra Fontanière, Alain Calender, Nader Hussein, Anne-Marie Morera, Nathalie di Clemente, Huguette Casse, Jieli Lu, Chang X. Zhang

Publikováno v: Endocrine-Related Cancer
Endocrine-Related Cancer, BioScientifica, 2008, 15 (1), pp. 217-27. ⟨10.1677/ERC-06-0046⟩

International audience; Multiple endocrine neoplasia type 1 (MEN1) results from the mutation of the predisposing gene, MEN1. Heterozygous Men1 mutant mice previously generated by several laboratories, including ours, mimic largely MEN1 pathology. Int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6663f7a483228b6087407961dd721d71
https://doi.org/10.1677/erc-06-0046

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N (6)-substituted AMPs inhibit mammalian deoxynucleotide N-hydrolase DNPH1

Autor: Pierre Alexandre Kaminski, Sylvie Pochet, Gilles Labesse, Claire Amiable, André Padilla

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2013, 8 (11), pp.e80755. 〈10.1371/journal.pone.0080755.t003〉
PLoS ONE, 2013, 8 (11), pp.e80755. ⟨10.1371/journal.pone.0080755.t003⟩
PLoS ONE, Vol 8, Iss 11, p e80755 (2013)
PLoS ONE, Public Library of Science, 2013, 8 (11), pp.e80755. ⟨10.1371/journal.pone.0080755.t003⟩
PLoS ONE, 2013, 8 (11), pp.e80755. ⟨10.1371/journal.pone.0080755⟩
'PloS One ', vol: 8, pages: e80755-1-e80755-11 (2013)

International audience; The gene dnph1 (or rcl) encodes a hydrolase that cleaves the 2'-deoxyribonucleoside 5'-monophosphate (dNMP) N-glycosidic bond to yield a free nucleobase and 2-deoxyribose 5-phosphate. Recently, the crystal structure of rat DNP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caca25acfaca62cdb78b11ea76043b71
https://hal-pasteur.archives-ouvertes.fr/pasteur-01472730/file/journal.pone.0080755.pdf

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