Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells

Autor: Stephen P. Jackson, Mareike Herzog, Alejandra Bruna, Luca Pellegrini, Violeta Serra, Mark J. O'Connor, Zhongwu Lai, Chloé Lescale, Jacqueline J.L. Jacobs, Fengtang Yang, Jonathan Lam, Matylda Sczaniecka-Clift, Abigail Shea, Carlos Caldas, Matthias Ostermaier, Gabriel Balmus, Julia Coates, Wenming Wei, Inge de Krijger, Yaron Galanty, Mukerrem Demir, Ludovic Deriano, Petra Beli, Domenic Pilger, Harveer Dev, Rimma Belotserkovskaya, Alistair Martin, Beiyuan Fu, Ting-Wei Will Chiang, Qian Wu

Publikováno v: Nature Cell Biology
Nature Cell Biology, 2018, 20 (8), pp.954-965. ⟨10.1038/s41556-018-0140-1⟩
Nature cell biology
Nature Cell Biology, Nature Publishing Group, 2018, 20 (8), pp.954-965. ⟨10.1038/s41556-018-0140-1⟩

International audience; BRCA1 deficiencies cause breast, ovarian, prostate and other cancers, and render tumours hypersensitive to poly(ADP-ribose) polymerase (PARP) inhibitors. To understand the resistance mechanisms, we conducted whole-genome CRISP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94c03882fb1aad0056e71d15c34e8ed4
https://www.repository.cam.ac.uk/handle/1810/282947

Assisted transcriptome reconstruction and splicing orthology

Autor: Anne Bergeron, Paul Guertin, Jean-Stéphane Varré, Samuel Blanquart, Amandine Perrin, Krister M. Swenson

Publikováno v: BMC Genomics
BMC Genomics, BioMed Central, 2016, Proceedings of the 14th Annual Research in Computational Molecular Biology (RECOMB) Comparative Genomics Satellite Workshop: genomics, 17 (Suppl 10), pp.786. ⟨10.1186/s12864-016-3103-6⟩
BMC Genomics, Vol 17, Iss S10, Pp 157-164 (2016)
BMC Genomics, 2016, Proceedings of the 14th Annual Research in Computational Molecular Biology (RECOMB) Comparative Genomics Satellite Workshop: genomics, 17 (Suppl 10), pp.786. ⟨10.1186/s12864-016-3103-6⟩

International audience; Background: Transcriptome reconstruction, defined as the identification of all protein isoforms that may be expressed by a gene, is a notably difficult computational task. With real data, the best methods based on RNA-seq data

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07ff4b687c4cc8ff1a3f89934888a731
https://hal.inria.fr/hal-01396410

Mice deficient for the epidermal dermokine β and γ isoforms display transient cornification defects

Autor: Nathalie Jonca, Anne Huchenq, Guy Serre, Emilie Leclerc, Sanja Kezic

Publikováno v: Journal of cell science, 127(Part 13), 2862-2872. Company of Biologists Ltd
Journal of Cell Science
Journal of Cell Science, 2014, 127 (13), pp.2862-2872. ⟨10.1242/jcs.144808⟩
Journal of Cell Science, Company of Biologists, 2014, 127 (13), pp.2862-2872. ⟨10.1242/jcs.144808⟩

International audience; Expression of the human dermokine gene (DMKN) leads to the production of four dermokine isoform families. The secreted α, β and γ isoforms have an epidermis-restricted expression pattern, with Dmkn β and γ being specifica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::076cfa563f3364839204565896569774
https://pure.amc.nl/en/publications/mice-deficient-for-the-epidermal-dermokine--and--isoforms-display-transient-cornification-defects(df4b76ca-0828-4b59-a52c-ae84d20f7a3e).html

Fanconi anemia in Tunisia: high prevalence of group A and identification of new FANCA mutations

Autor: Bouchlaka, Chiraz, Abdelhak, Sonia, Amouri, Ahlem, Ben Abid, Hela, Hadiji, Sondes, Frikha, Mounir, Ben Othman, Tarek, Amri, Fethi, Ayadi, Hammadi, Hachicha, Mongia, Rebaï, Ahmed, Saad, Ali, Dellagi, Koussay, Group, Tunisian Fanconi Anemia Study

Publikováno v: Journal of Human Genetics
Journal of Human Genetics, Nature Publishing Group, 2003, 48 (7), pp.352--361. ⟨10.1007/s10038-003-0037-z⟩

International audience; Fanconi anemia (FA) is a rare autosomal recessive disease characterized by progressive pancytopenia, congenital malformations, and predisposition to acute myeloid leukemia. Fanconi anemia is genetically heterogeneous, with at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eab079aff3119a761cb31f9cdee92312
https://pubmed.ncbi.nlm.nih.gov/12827451