Výsledky vyhledávání - "MESH: Protein Kinase Inhibitors/pharmacology"

Identification of Piperazinylbenzenesulfonamides as New Inhibitors of Claudin-1 Trafficking and Hepatitis C Virus Entry

Autor: Sandrine Belouzard, Jens Bukh, Lucie Fénéant, Priscille Brodin, Yves Rouillé, Jean Dubuisson, Laura Riva, Thomas F. Baumert, Alexandre Vandeputte, François Helle, Jannick Prentoe, Laurent L'homme, Laurence Cocquerel, Charles-Henry Gattolliat, Ok-Ryul Song, Tarik Asselah

Publikováno v: Journal of Virology
Journal of Virology, 2018, 92 (10), pp.e01982-17. ⟨10.1128/JVI.01982-17⟩
Journal of Virology, American Society for Microbiology, 2018, 92 (10), pp.e01982-17. ⟨10.1128/JVI.01982-17⟩

Hepatitis C virus (HCV) infection causes 500,000 deaths annually, in association with end-stage liver diseases. Investigations of the HCV life cycle have widened the knowledge of virology, and here we discovered that two piperazinylbenzenesulfonamide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eede9d22a44a24224a0d9eb270333e63
https://pubmed.ncbi.nlm.nih.gov/29491159

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Active-site mTOR inhibitors augment HSV1-dICP0 infection in cancer cells via dysregulated eIF4E/4E-BP axis

Publikováno v: Zakaria, C, Sean, P, Hoang, H-D, Leroux, L-P, Watson, M, Workenhe, S T, Hearnden, J, Pearl, D, Truong, V T, Robichaud, N, Yanagiya, A, Tahmasebi, S, Jafarnejad, S M, Jia, J-J, Pelin, A, Diallo, J-S, Le Boeuf, F, Bell, J C, Mossman, K L, Graber, T E, Jaramillo, M, Sonenberg, N & Alain, T 2018, ' Active-site mTOR inhibitors augment HSV1-dICP0 infection in cancer cells via dysregulated eIF4E/4E-BP axis ', PLoS Pathogens, vol. 14, no. 8, e1007264 . https://doi.org/10.1371/journal.ppat.1007264
PLoS Pathogens
PLoS Pathogens, Public Library of Science, 2018, 14 (8), pp.e1007264. ⟨10.1371/journal.ppat.1007264⟩
PLoS Pathogens, Vol 14, Iss 8, p e1007264 (2018)

International audience; Herpes Simplex Virus 1 (HSV1) is amongst the most clinically advanced oncolytic virus platforms. However, efficient and sustained viral replication within tumours is limiting. Rapamycin can stimulate HSV1 replication in cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c92dee5a0216e1929b4920ce8f0aa3
https://pubmed.ncbi.nlm.nih.gov/30138450

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The tyrosine kinase inhibitor imatinib mesylate suppresses uric acid crystal-induced acute gouty arthritis in mice

Autor: Dongmin Kang, Stephan Rogalla, Bianca Balbino, Riccardo Sibilano, Harini Raghu, Philipp Starkl, Christopher H. Contag, Stephen J. Galli, Steven Sensarn, William H. Robinson, Laurent L. Reber, Jeremy Sokolove, Mindy Tsai, Nicolas Gaudenzio

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2017, 12 (10), pp.e0185704. ⟨10.1371/journal.pone.0185704⟩
PLoS ONE, 2017, 12 (10), pp.e0185704. ⟨10.1371/journal.pone.0185704⟩
PLOS ONE
PLoS ONE, Vol 12, Iss 10, p e0185704 (2017)

International audience; Gouty arthritis is caused by the deposition of monosodium urate (MSU) crystals in joints. Despite many treatment options for gout, there is a substantial need for alternative treatments for patients unresponsive to current the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6be15d586a565a2645015ff5c6a2b50e
https://hal.sorbonne-universite.fr/hal-01622753

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Zika Virus Disrupts Phospho-TBK1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial Glia

Publikováno v: Cell Reports
Cell Reports, Elsevier Inc, 2016, 16 (10), pp.2576-2592. ⟨10.1016/j.celrep.2016.08.038⟩
Cell Reports, 2016, 16 (10), pp.2576-2592. ⟨10.1016/j.celrep.2016.08.038⟩
Cell Reports, Vol 16, Iss 10, Pp 2576-2592 (2016)

SummaryThe mechanisms underlying Zika virus (ZIKV)-related microcephaly and other neurodevelopment defects remain poorly understood. Here, we describe the derivation and characterization, including single-cell RNA-seq, of neocortical and spinal cord

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8842a91c108e53c206bfa4ca694b4d28
https://hal-pasteur.archives-ouvertes.fr/pasteur-01739212

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Identification of Novel Compounds Inhibiting Chikungunya Virus-Induced Cell Death by High Throughput Screening of a Kinase Inhibitor Library

Autor: Camila T. da Silva, Joo Hwan No, Michael Adsetts Edberg Hansen, Olivier Schwartz, Deu John M. Cruz, Rafaela Milan Bonotto, Lucio H. Freitas-Junior, Juliana B. Taniguchi, Rafael G. B. Gomes, Benoit Lombardot

Publikováno v: Web of Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Public Library of Science, 2012, 7 (10), pp.e2471. ⟨10.1371/journal.pntd.0002471⟩
PLoS Neglected Tropical Diseases, 2012, 7 (10), pp.e2471. ⟨10.1371/journal.pntd.0002471⟩
PLoS Neglected Tropical Diseases, Vol 7, Iss 10, p e2471 (2013)

Chikungunya virus (CHIKV) is a mosquito-borne arthrogenic alphavirus that causes acute febrile illness in humans accompanied by joint pains and in many cases, persistent arthralgia lasting weeks to years. The re-emergence of CHIKV has resulted in num

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24ee31113a39ce2c4f1e7d26bebb9bdc

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αvβ5/β6 integrin suppression leads to a stimulation of α2β1 dependent cell migration resistant to PI3K/Akt inhibition

Autor: Céline, Defilles, Jean-Claude, Lissitzky, Marie-Pierre, Montero, Frédéric, André, Charles, Prévot, Estelle, Delamarre, Naziha, Marrakchi, José, Luis, Véronique, Rigot

Publikováno v: Experimental Cell Research
Experimental Cell Research, Elsevier, 2009, 315 (11), pp.1840-1849. 〈10.1016/j.yexcr.2009.03.014〉
Experimental Cell Research, Elsevier, 2009, 315 (11), pp.1840-1849. ⟨10.1016/j.yexcr.2009.03.014⟩

International audience; Crosstalk between integrins is involved in the regulation of various cell functions including cell migration. Here we identify the interplay between the integrins alpha v beta 5/beta 6 and alpha 2 beta 1 during cell migration

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::07d9457faf99fce16e0392ffc4d028eb
https://hal-riip.archives-ouvertes.fr/pasteur-01375182

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alpha v beta 5/beta 6 integrin suppression leads to a stimulation of alpha 2 beta 1 dependent cell migration resistant to PI3K/Akt inhibition

Autor: Véronique Rigot, Céline Defilles, Jean-Claude Lissitzky, Estelle Delamarre, Naziha Marrakchi, Marie-Pierre Montero, Charles Prévôt, Frédéric André, José Luis

Publikováno v: Experimental Cell Research
Experimental Cell Research, Elsevier, 2009, 315 (11), pp.1840-1849. ⟨10.1016/j.yexcr.2009.03.014⟩

Crosstalk between integrins is involved in the regulation of various cell functions including cell migration. Here we identify the interplay between the integrins alpha v beta 5/beta 6 and alpha 2 beta 1 during cell migration toward type I collagen.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2f47b03b489761005cbd4506f893b8
https://hal-riip.archives-ouvertes.fr/pasteur-02049092

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