Hypoxia Down-regulates CCAAT/Enhancer Binding Protein-α Expression in Breast Cancer Cells

Autor: Robert Barouki, Etienne Blanc, Nathalie M. Mazure, Fabrice Lecuru, Marie-Claude Fulchignoni-Lataud, Marie-Aude Le Frere Belda, Anne Dreiem, Thérèse Hervèe Mayi, Charbel Massaad, Vincent Favaudon, Liliane Massaad-Massade, Ramzi Seifeddine

Publikováno v: Cancer Research
Cancer Research, American Association for Cancer Research, 2008, 68 (7), pp.2158-65. ⟨10.1158/0008-5472.CAN-07-1190⟩
Cancer Research, 2008, 68 (7), pp.2158-65. ⟨10.1158/0008-5472.CAN-07-1190⟩
Cancer Research, American Association for Cancer Research, 2008, 68 (7), pp.2158-65. 〈10.1158/0008-5472.CAN-07-1190〉

International audience; The transcription factor CCAAT/enhancer binding protein-alpha (C/EBP alpha) is involved in the control of cell differentiation and proliferation, and has been suggested to act as a tumor suppressor in several cancers. By using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b155d9f81fcc6f41e3f4818c19beb9a0
https://doi.org/10.1158/0008-5472.can-07-1190

A TFTC/STAGA Module Mediates Histone H2A and H2B Deubiquitination, Coactivates Nuclear Receptors, and Counteracts Heterochromatin Silencing

Autor: Didier Devys, Hendrik G. Stunnenberg, Ken-ichi Takeyama, Yue Zhao, Shigeaki Kato, Laszlo Tora, Xavier Le Guezennec, Roland Schüle, Shun Sawatsubashi, Eric Metzger, Jacques Bonnet, Sofia G. Georgieva, Eriko Suzuki, Guillaume Lang, Aleksey N. Krasnov, Saya Ito

Publikováno v: Molecular Cell, 29, 92-101
Molecular Cell, 29, 1, pp. 92-101
Molecular Cell
Molecular Cell, 2008, 29 (1), pp.92-101. ⟨10.1016/j.molcel.2007.12.011⟩
Molecular Cell, Elsevier, 2008, 29 (1), pp.92-101. ⟨10.1016/j.molcel.2007.12.011⟩

International audience; Transcriptional activators, several different coactivators, and general transcription factors are necessary to access specific loci in the dense chromatin structure to allow precise initiation of RNA polymerase II (Pol II) tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85dcd6ec98aeb72557dbe46ac978f1e0

Differential Binding of Poly(ADP-Ribose) Polymerase-1 and JunD/Fra2 Accounts for RANKL-Induced Tcirg1 Gene Expression During Osteoclastogenesis

Autor: David Momier, Jean-Claude Scimeca, Guillaume E. Beranger, Michel Samson, Georges F. Carle, Jean-Marie Guigonis

Publikováno v: Journal of Bone and Mineral Research
Journal of Bone and Mineral Research, American Society for Bone and Mineral Research, 2007, 22 (7), pp.975-83. ⟨10.1359/jbmr.070406⟩
Journal of Bone and Mineral Research, American Society for Bone and Mineral Research, 2007, 22 (7), pp.975-983. ⟨10.1359/jbmr.070406⟩
Journal of Bone and Mineral Research, 2007, 22 (7), pp.975-983. ⟨10.1359/jbmr.070406⟩
Journal of Bone and Mineral Research, 2007, 22 (7), pp.975-83. ⟨10.1359/jbmr.070406⟩

We studied Tcirg1 gene expression on RANKL-induced osteoclastic differentiation of the mouse model RAW264.7 cells. We identified a mechanism involving PARP-1 inhibition release and JunD/Fra-2 binding, which is responsible for Tcirg1 gene upregulation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::266f601864e3af202978b71641c3c0dc
https://doi.org/10.1359/jbmr.070406

Unexpected paracrine action of prostate cancer cells harboring a new class of androgen receptor mutation—A new paradigm for cooperation among prostate tumor cells

Autor: Audrey Monge, Gemma Marcias, Pascal Kessler, Eva Erdmann, Gaëlle Lapouge, Sebastian Serra, Hervé Lang, Monika Jagla, Jocelyn Céraline, Jean-Pierre Bergerat, Didier Jacqmin

Publikováno v: International Journal of Cancer
International Journal of Cancer, Wiley, 2007, 121 (6), pp.1238-44. ⟨10.1002/ijc.22830⟩

The emergence of mutations in the androgen receptor (AR) gene is a recurrent event during progression of prostate cancer (PCa) on androgen ablation therapy. In this study, we show that nonsense mutations that lead to carboxyl-terminal end truncated A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd7394c6091838adad4f136af21e1b19
https://doi.org/10.1002/ijc.22830

The human basonuclin 2 gene has the potential to generate nearly 90,000 mRNA isoforms encoding over 2000 different proteins

Autor: Amandine Vanhoutteghem, Philippe Djian

Publikováno v: Genomics / Physiol Genomics
Genomics / Physiol Genomics, 2007, 89 (1), pp.44-58. ⟨10.1016/j.ygeno.2006.07.006⟩

The number of mRNAs and proteins that can be produced from a single gene is known to be increased by the number of start sites and by multiple splicing of products. A few genes have been found to generate extraordinarily large numbers of splicing iso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7febe8c9304a80e2ca9784c95f08912