Prions of Yeast: From Cytoplasmic Genes to Heritable Amyloidosis

Autor: Masison, D, Roberts, B.Tibor, Wickner, Reed, Edskes, Herman, Taylor, Kimberly, Maddelein, Marie-Lise, Moriyama, Hiromitsu, Tibor Roberts, B, Roberts, B. Tibor

Publikováno v: Molecular Pathology of the Prions
Molecular Pathology of the Prions, 59 (2), Humana Press, pp.237-267, 2019, ⟨10.1385/1-59259-134-5:237⟩

International audience; It was believed that only proteins could carry out enzymatic reactions, and only nucleic acids could mediate inheritance. In recent years, the work of Cech and Altman and others has shown that nucleic acids can catalyze reacti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8150fe9ec33d9c4e3065fc3051953695
https://hal.archives-ouvertes.fr/hal-02418241

Proteomic consequences of expression and pathological conversion of the prion protein in inducible neuroblastoma N2a cells

Autor: Stéphane Roche, Manuela Pastore, Monique Provansal, Sandrine Alais, Maxime Belondrade, Danielle Casanova, Pascal Leblanc, Sylvain Lehmann, Otto Windl

Publikováno v: Prion
Prion, Taylor & Francis, 2014, 4 (4), pp.292-301. ⟨10.4161/pri.4.4.13435⟩
Prion, 2010, 4 (4), pp.4, 4. ⟨10.4161/pri.4.4.13435⟩
Prion, Taylor & Francis, 2010, 4 (4), pp.4, 4. ⟨10.4161/pri.4.4.13435⟩

International audience; Neurodegenerative diseases are often associated with misfolding and deposition of specific proteins in the nervous system. The prion protein, which is associated with transmissible spongiform encephalopathies (TSEs), is one of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::362a1537263c00525c429f13f62a793c
https://hal.archives-ouvertes.fr/hal-02132261

Beyond PrP9res) type 1/type 2 dichotomy in Creutzfeldt-Jakob disease

Autor: Uro-Coste, Emmanuelle, Cassard, Hervé, Simon, Stéphanie, Lugan, Séverine, Bilheude, Jean-Marc, Perret-Liaudet, Armand, Ironside, James, Haik, Stéphane, Basset-Leobon, Christelle, Lacroux, Caroline, Peoch', Katell, Streichenberger, Nathalie, Langeveld, Jan, Head, Mark, Grassi, Jacques, Hauw, Jean-Jacques, Schelcher, Francois, Delisle, Marie Bernadette, Andréoletti, Olivier

Publikováno v: PLoS Pathogens
PLoS Pathogens, 2008, 4 (3), pp.e1000029. ⟨10.1371/journal.ppat.1000029⟩
PLoS Pathogens, Public Library of Science, 2008, 4 (3), pp.e1000029. ⟨10.1371/journal.ppat.1000029⟩
PLoS Pathogens, Vol 4, Iss 3, p e1000029 (2008)

Sporadic Creutzfeldt-Jakob disease (sCJD) cases are currently subclassified according to the methionine/valine polymorphism at codon 129 of the PRNP gene and the proteinase K (PK) digested abnormal prion protein (PrPres) identified on Western blottin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c0e6ec39b59628b87dc54e49bfb97ccb
https://www.hal.inserm.fr/inserm-00421129/document

Prion protein activates and fixes complement directly via the classical pathway: implications for the mechanism of scrapie agent propagation in lymphoid tissue

Autor: Daniel A. Mitchell, Susan M. Paulin, Christian L. Villiers, Robert B. Sim, Louise Kirby

Publikováno v: Molecular Immunology
Molecular Immunology, 2007, 44 (11), pp.2997-3004. ⟨10.1016/j.molimm.2006.12.027⟩
Molecular Immunology, Elsevier, 2007, 44 (11), pp.2997-3004. ⟨10.1016/j.molimm.2006.12.027⟩

International audience; C1q-deficient and complement depleted mice are highly resistant to intraperitoneal scrapie infection. The molecular mechanisms of complement involvement in scrapie pathogenesis remain unclear. Previous detailed studies have in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba169ba90dfb21e394b0ee93ee75e3fe
https://www.hal.inserm.fr/inserm-00267049

Prion infection-impaired functional blocks identified by proteomics enlighten the targets and the curing pathways of an anti-prion drug

Autor: B. Schaeffer, Jeanne Grosclaude, F. Mouthon, A.-P. Bouin, J.-P. Deslys, Jean-François Chich, C. Larramendy, V. Labas

Publikováno v: Biochimica et Biophysica Acta-Molecular Cell Research
Biochimica et Biophysica Acta-Molecular Cell Research, Elsevier, 2007, 1774 (1), pp.154-67. ⟨10.1016/j.bbapap.2006.10.016⟩
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics, 2006, 1774, pp.154-167. ⟨10.1016/j.bbapap.2006.10.016⟩
Biochimica et Biophysica Acta-Molecular Cell Research, 2007, 1774 (1), pp.154-67. ⟨10.1016/j.bbapap.2006.10.016⟩

International audience; Prion-induced neurodegeneration results from multiple cellular alterations among which the accumulation of a modified form of the host protein PrP is but a hallmark. Drug treatments need understanding of underlying mechanisms.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5d38caf00a2e18fb1f54f82fcc4ea48
https://www.hal.inserm.fr/inserm-00173000