Regulation of ALT-associated homology-directed repair by polyADP-ribosylation

Autor: Ian D. Waddell, Robert W. Sobol, Kate M. Smith, Justin L. Roncaioli, Felipe da Veiga Leprevost, Song My Hoang, Dattatreya Mellacharevu, Dominique Ray-Gallet, Michelle L. Lynskey, Roderick J. O’Sullivan, Ragini Bhargava, Jonathan Barroso-González, Nicole Kaminski, Geneviève Almouzni, Anne R. Wondisford, Jianfeng Li, Donald J. Ogilvie, Alexey I. Nesvizhskii, Dominic I. James, Callen T. Wallace, Simon C. Watkins, Laura García-Expósito

Publikováno v: Nature Structural and Molecular Biology
Nature Structural and Molecular Biology, Nature Publishing Group, 2020, 27 (12), pp.1152-1164. ⟨10.1038/s41594-020-0512-7⟩
Nature Structural & Molecular Biology
Nature Structural and Molecular Biology, 2020, 27 (12), pp.1152-1164. ⟨10.1038/s41594-020-0512-7⟩
Nat Struct Mol Biol

International audience; The synthesis of poly(ADP-ribose) (PAR) reconfigures the local chromatin environment and recruits DNA-repair complexes to damaged chromatin. PAR degradation by poly(ADP-ribose) glycohydrolase (PARG) is essential for progressio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04d45f0c33f255ca7323659e74359498
https://hal.sorbonne-universite.fr/hal-03138406

Activation of Toll-Like Receptors Differentially Modulates Inflammation in the Human Reproductive Tract: Preliminary Findings

Autor: Fahd, Benjelloun, Héloïse, Quillay, Claude, Cannou, Romain, Marlin, Yoann, Madec, Hervé, Fernandez, Fabrice, Chrétien, Roger, Le Grand, Françoise, Barré-Sinoussi, Marie-Thérèse, Nugeyre, Elisabeth, Menu

Publikováno v: Frontiers in Immunology
Frontiers in Immunology, 2020, 11, pp.1655. ⟨10.3389/fimmu.2020.01655⟩
Frontiers in Immunology, Frontiers, 2020, 11, pp.1655. ⟨10.3389/fimmu.2020.01655⟩

International audience; The female reproductive tract (FRT) is the main site of entry of sexually transmitted infections (STIs). Toll-like receptors (TLRs) that recognize pathogenic motifs are widely expressed in the FRT. TLR stimulation induces immu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7e26c1a648496774a4eee4e4afff2373
https://hal-pasteur.archives-ouvertes.fr/pasteur-03197331/document

PARP-1/PARP-2 double deficiency in mouse T cells results in faulty immune responses and T lymphomas

Autor: Beatriz Revilla-Nuin, Beatriz Gozalbo-López, Margarita Del Val, Sandra Segura-Bayona, José Yélamos, Philip A. Knobel, Andrea C. Méndez, Valérie Schreiber, Jordi Farrés, Carlos Martinez, Travis H. Stracker, Coral Ampurdanés, Françoise Dantzer, María F. Bueno, Juan Martín-Caballero, David M. Arana, Miguel Galindo-Campos, Pedro Aparicio, J.A. Navarro

Publikováno v: Scientific Reports
Digital.CSIC. Repositorio Institucional del CSIC
instname
Scientific Reports, Nature Publishing Group, 2017, 7, pp.41962. ⟨10.1038/srep41962⟩
Europe PubMed Central

The maintenance of T-cell homeostasis must be tightly regulated. Here, we have identified a coordinated role of Poly(ADP-ribose) polymerase-1 (PARP-1) and PARP-2 in maintaining T-lymphocyte number and function. Mice bearing a T-cell specific deficien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea38903a9c22b5cb5936c5cfcec310a2
http://hdl.handle.net/10261/166308

Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells

Autor: Stephen P. Jackson, Mareike Herzog, Alejandra Bruna, Luca Pellegrini, Violeta Serra, Mark J. O'Connor, Zhongwu Lai, Chloé Lescale, Jacqueline J.L. Jacobs, Fengtang Yang, Jonathan Lam, Matylda Sczaniecka-Clift, Abigail Shea, Carlos Caldas, Matthias Ostermaier, Gabriel Balmus, Julia Coates, Wenming Wei, Inge de Krijger, Yaron Galanty, Mukerrem Demir, Ludovic Deriano, Petra Beli, Domenic Pilger, Harveer Dev, Rimma Belotserkovskaya, Alistair Martin, Beiyuan Fu, Ting-Wei Will Chiang, Qian Wu

Publikováno v: Nature Cell Biology
Nature Cell Biology, 2018, 20 (8), pp.954-965. ⟨10.1038/s41556-018-0140-1⟩
Nature cell biology
Nature Cell Biology, Nature Publishing Group, 2018, 20 (8), pp.954-965. ⟨10.1038/s41556-018-0140-1⟩

International audience; BRCA1 deficiencies cause breast, ovarian, prostate and other cancers, and render tumours hypersensitive to poly(ADP-ribose) polymerase (PARP) inhibitors. To understand the resistance mechanisms, we conducted whole-genome CRISP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94c03882fb1aad0056e71d15c34e8ed4
https://www.repository.cam.ac.uk/handle/1810/282947

A potential robust antiviral defense state in the common vampire bat: Expression, induction and molecular characterization of the three interferon-stimulated genes -OAS1, ADAR1 and PKR

Autor: Stéphanie Dabo, Christine Neuveut, Vincent Lacoste, Marie-Claude Lise, Eliane F. Meurs, Anne Lavergne, Sarkis Sarkis

Publikováno v: Developmental and Comparative Immunology
Developmental and Comparative Immunology, 2018, 85, pp.95-107. ⟨10.1016/J.DCI.2018.04.006⟩
Developmental and Comparative Immunology, Elsevier, 2018, 85, pp.95-107. ⟨10.1016/J.DCI.2018.04.006⟩

Bats are known to harbor many zoonotic viruses, some of which are pathogenic to other mammals while they seem to be harmless in bats. As the interferon (IFN) response represents the first line of defense against viral infections in mammals, it is hyp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33e58b3847c55cac981f1ea20ac5c8f2
https://pubmed.ncbi.nlm.nih.gov/29635006