Genomic variation during culture adaptation of genetically complex Plasmodium falciparum clinical isolates

Autor: Antoine Claessens, Lindsay B. Stewart, Eleanor Drury, Ambroise D. Ahouidi, Alfred Amambua-Ngwa, Mahamadou Diakite, Dominic P. Kwiatkowski, Gordon A. Awandare, David J. Conway

Publikováno v: Microbial Genomics
Microbial Genomics, 2023, 9 (5), ⟨10.1099/mgen.0.001009⟩

Experimental studies on the biology of malaria parasites have mostly been based on laboratory-adapted lines, but there is limited understanding of how these may differ from parasites in natural infections. Loss-of-function mutants have previously bee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d414b1778d4f013870ca250056decb17
https://doi.org/10.1099/mgen.0.001009

Clinical and In Vitro Resistance of Plasmodium falciparum to Artesunate-Amodiaquine in Cambodia

Autor: Saorin Kim, Chhayleang Kauy, Maria Dorina Bustos, Nimol Kloeung, Rotha Eam, Nimol Khim, Denis Mey Bouth, Sopheakvatey Ke, Brigitte Izac, Benoit Witkowski, Rithea Leang, Melissa Mairet-Khedim, Pascal Ringwald, Frédéric Ariey, Camille Marmai, Sophy Chy

Publikováno v: Clinical Infectious Diseases
Clinical Infectious Diseases, Oxford University Press (OUP), 2021, 73 (3), pp.406-413. ⟨10.1093/cid/ciaa628⟩
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Clinical Infectious Diseases, 2021, 73 (3), pp.406-413. ⟨10.1093/cid/ciaa628⟩

Background Artesunate-amodiaquine is a potential therapy for uncomplicated malaria in Cambodia. Methods Between September 2016 and January 2017, artesunate-amodiaquine efficacy and safety were evaluated in a prospective, open-label, single-arm observ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f7a408552281144c8b508c0408f3cc6
https://doi.org/10.1093/cid/ciaa628

The actomyosin interface contains an evolutionary conserved core and an ancillary interface involved in specificity

Autor: Robert-Paganin, Julien, Xu, Xiao-Ping, Swift, Mark F., Auguin, Daniel, Robblee, James P., Lu, Hailong, Fagnant, Patricia M., Krementsova, Elena B., Trybus, Kathleen M., Houdusse, Anne, Volkmann, Niels, Hanein, Dorit

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), ⟨10.1038/s41467-021-22093-4⟩
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications, 2021, 12 (1), pp.1892. ⟨10.1038/s41467-021-22093-4⟩
Nature Communications, Nature Publishing Group, 2021, 12, pp.1892. ⟨10.1038/s41467-021-22093-4⟩

Plasmodium falciparum, the causative agent of malaria, moves by an atypical process called gliding motility. Actomyosin interactions are central to gliding motility. However, the details of these interactions remained elusive until now. Here, we repo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::16f578a1e98ec3e1446fa8abc7b3dfd5
https://hal.archives-ouvertes.fr/hal-03365209

Misdiagnosis of imported falciparum malaria from African areas due to an increased prevalence of pfhrp2/pfhrp3 gene deletion: the Djibouti case

Autor: Iriart, Xavier, Menard, Sandie, Chauvin, Pamela, Mohamed, Hasna, Charpentier, Elena, Mohamed, Mohamed, Berry, Antoine, Aboubaker, Mohamed

Publikováno v: Emerging microbes & infections
Emerging microbes & infections, 2020, 9 (1), pp.1984-1987. ⟨10.1080/22221751.2020.1815590⟩

International audience; Following the diagnosis of a falciparum malaria case imported from Djibouti and not detected by a pfHRP2-based rapid diagnostic test (RDT), we investigated the prevalence of the pfhrp2/pfhrp3-deleted parasites in Djibouti usin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1398::46f91bf19ab5582d95b6d8ccc57481c3
https://ut3-toulouseinp.hal.science/hal-03526514/document

Role of a patatin-like phospholipase in Plasmodium falciparum gametogenesis and malaria transmission

Autor: Aditi Alaganan, Chetan E. Chitnis, Lhousseine Touqui, Julien Guglielmini, Kunal R. More, Micheline Guillotte Blisnick, Sabine Thiberge, Shailja Singh, Audrey Lorthiois, Olivier Gorgette, Pallavi Singh, Shivani Shankar Aguilera

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, 116 (35), pp.17498-17508. ⟨10.1073/pnas.1900266116⟩
Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (35), pp.17498-17508. ⟨10.1073/pnas.1900266116⟩

International audience; Transmission of Plasmodium falciparum involves a complex process that starts with the ingestion of gametocytes by female Anopheles mosquitoes during a blood meal. Activation of gametocytes in the mosquito midgut triggers "roun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcde94b87420e035dae4c10cfcf1d635
https://hal-pasteur.archives-ouvertes.fr/pasteur-02890967