Výsledky vyhledávání - "MESH: Plasmodium berghei"

Transmission-blocking compound candidates against Plasmodium vivax using P. berghei as an initial screening

Autor: Wuelton Marcelo Monteiro, Alexandre Oliveira Trindade, Macejane Ferreira Souza, Stefanie C. P. Lopes, Fabio T. M. Costa, Rogerio Amino, Claudia María Ríos-Velásquez, Marcus V. G. Lacerda, Francy's Sayara Andrade, Camila Fabbri

Publikováno v: Memórias do Instituto Oswaldo Cruz., Vol 116 (2021)
Memórias do Instituto Oswaldo Cruz
Memórias do Instituto Oswaldo Cruz, Instituto Oswaldo Cruz, Ministério da Saúde, 2021, 116, pp.e200513. ⟨10.1590/0074-02760200513⟩
Memórias do Instituto Oswaldo Cruz, 2021, 116, pp.e200513. ⟨10.1590/0074-02760200513⟩
Memórias do Instituto Oswaldo Cruz, Volume: 116, Article number: e200513, Published: 08 FEB 2021

International audience; Background: Different strategies for improvement of malaria control and elimination are based on the blockage of malaria parasite transmission to the mosquito vector. These strategies include the drugs that target the plasmodi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5b7f1e900f4c63f085fe4ac784802b4
http://www.scielo.br/pdf/mioc/v116/1678-8060-mioc-116-e200513.pdf

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Identification of novel quinazoline derivatives as potent antiplasmodial agents

Autor: Johan Schultz, Dany Pechalrieu, Sergio Valente, Anne Bouchut, Tina S. Skinner-Adams, Giancarlo Fabrizi, Paola B. Arimondo, Urban Hoglund, Katherine T. Andrews, Roberta Mazzone, Sophia Lafitte, Antonello Mai, Alessia Lucidi, Christine Pierrot, Ming Jang Chua, Jamal Khalife, Dante Rotili

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2019, 161, pp.277-291. ⟨10.1016/j.ejmech.2018.10.041⟩
European Journal of Medicinal Chemistry, 2019, 161, pp.277-291. ⟨10.1016/j.ejmech.2018.10.041⟩

International audience; Despite the recent reductions in the global burden of malaria, this disease remains a devastating cause of death in tropical and subtropical regions. As there is no broadly effective vaccine for malaria, prevention and treatme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4a86e82c36d3a424ed430d178a588e9
http://hdl.handle.net/20.500.12210/34198

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Local Immune Response to Injection of Plasmodium Sporozoites into the Skin

Autor: Michèle Berthet, Matthew L. Albert, Yasemin Virk, Matthew R. Buckwalter, Pascale Gueirard, Robert Ménard, Laura Mac-Daniel, Katsuyuki Yui

Publikováno v: Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2014, 193 (3), pp.1246-1257. ⟨10.4049/jimmunol.1302669⟩
Journal of Immunology, 2014, 193 (3), pp.1246-1257. ⟨10.4049/jimmunol.1302669⟩

Malarial infection is initiated when the sporozoite form of the Plasmodium parasite is inoculated into the skin by a mosquito. Sporozoites invade hepatocytes in the liver and develop into the erythrocyte-infecting form of the parasite, the cause of c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6f59442438be9d33b2cdfeca2fdb2e7
https://doi.org/10.4049/jimmunol.1302669

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Cytotoxic anti-circumsporozoite antibodies target malaria sporozoites in the host skin

Autor: Silvia Beatriz Boscardin, Tomoko Ishino, Marcio Massao Yamamoto, Olivier Silvie, Rogerio Amino, Sylvie Dartevelle, François Traincard, Masao Yuda, Raquel Hoffmann Panatieri, Joana Tavares, Eduardo Aliprandini, Sabine Thiberge

Publikováno v: Nature Microbiology
Nature Microbiology, 2018, 3 (11), pp.1224-1233. ⟨10.1038/s41564-018-0254-z⟩
Nature Microbiology, Nature Publishing Group, 2018, 3 (11), pp.1224-1233. ⟨10.1038/s41564-018-0254-z⟩

The circumsporozoite protein (CSP) is the major surface protein of malaria sporozoites (SPZs), the motile and invasive parasite stage inoculated in the host skin by infected mosquitoes. Antibodies against the central CSP repeats of different plasmodi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa2509cadccb0712c3f129f6b4f3ed9b
https://hal-pasteur.archives-ouvertes.fr/pasteur-02425448

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Role of host cell traversal by the malaria sporozoite during liver infection

Autor: Rogerio Amino, Joana Tavares, Nico van Rooijen, Elodie Mordelet, Robert Ménard, Alexander Medvinsky, Sabine Thiberge, Pauline Formaglio

Publikováno v: Journal of Experimental Medicine; Vol 210
Tavares, J, Formaglio, P, Thiberge, S, Mordelet, E, van Rooijen, N, Medvinsky, A, Menard, R & Amino, R 2013, ' Role of host cell traversal by the malaria sporozoite during liver infection ', Journal of Experimental Medicine, vol. 210, no. 5, pp. 905-915 . https://doi.org/10.1084/jem.20121130
Journal of Experimental Medicine
Journal of Experimental Medicine, Rockefeller University Press, 2013, 210 (5), pp.905-915. ⟨10.1084/jem.20121130⟩
Journal of Experimental Medicine, 210(5), 905-915. Rockefeller University Press
The Journal of Experimental Medicine
Journal of Experimental Medicine, 2013, 210 (5), pp.905-915. ⟨10.1084/jem.20121130⟩
Tavares, J, Formaglio, P, Thiberge, S, Mordelet, E, Van Rooijen, N, Medvinsky, A, Ménard, R & Amino, R 2013, ' Role of host cell traversal by the malaria sporozoite during liver infection ', Journal of Experimental Medicine, vol. 210, no. 5, pp. 905-915 . https://doi.org/10.1084/jem.20121130

Malaria sporozoites cross the liver sinusoidal barrier, target Kupffer cells and endothelial cells with cell traversal inhibiting sporozoite clearance.
Malaria infection starts when the sporozoite stage of the Plasmodium parasite is injected int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92f4b51bb90a263d20203a2121df7d5a

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In vivo imaging of pathogen homing to the host tissues

Autor: Ana Rafaela Teixeira, David Costa, Rogerio Amino, Joana Tavares, Anabela Cordeiro-da-Silva

Publikováno v: Methods
Methods, 2017, 127, pp.37-44. ⟨10.1016/j.ymeth.2017.05.008⟩
Methods, Elsevier, 2017, 127, pp.37-44. ⟨10.1016/j.ymeth.2017.05.008⟩
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Hematogenous dissemination followed by tissue tropism is a characteristic of the infectious process of many pathogens including those transmitted by blood-feeding vectors. After entering into the blood circulation, these pathogens must arrest in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bf3bbbef62a3dfb3640cb331b5e51a9
https://hal-pasteur.archives-ouvertes.fr/pasteur-02425469

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Calcium dynamics of Plasmodium berghei sporozoite motility

Autor: Carey, Allison, Singer, Mirko, Bargieri, Daniel, Thiberge, Sabine, Frischknecht, Friedrich, Ménard, Robert, Amino, Rogerio

Publikováno v: Cellular Microbiology
Cellular Microbiology, Wiley, 2014, 16 (5), pp.768-783. ⟨10.1111/cmi.12289⟩
Cellular Microbiology, 2014, 16 (5), pp.768-783. ⟨10.1111/cmi.12289⟩

International audience; Calcium is a key signalling molecule in apicomplexan parasites and plays an important role in diverse processes including gliding motility. Gliding is essential for the malaria parasite to migrate from the skin to the liver as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c111b548759ba948bc715ced22a4ee7a
https://hal-pasteur.archives-ouvertes.fr/pasteur-02425474

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The Fatty Acid Biosynthesis Enzyme FabI Plays a Key Role in the Development of Liver-Stage Malarial Parasites

Publikováno v: Cell Host and Microbe
Cell Host and Microbe, Elsevier, 2008, 4 (6), pp.567-78. ⟨10.1016/j.chom.2008.11.001⟩

International audience; The fatty acid synthesis type II pathway has received considerable interest as a candidate therapeutic target in Plasmodium falciparum asexual blood-stage infections. This apicoplast-resident pathway, distinct from the mammali

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::746a1c500f373f1b157af12563485617
https://doi.org/10.1016/j.chom.2008.11.001

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Suppression of CD4+ Effector Responses by Naturally Occurring CD4+ CD25+ Foxp3+ Regulatory T Cells Contributes to Experimental Cerebral Malaria

Autor: Blanc, Anne-Laurence, Keswani, Tarun, Gorgette, Olivier, Bandeira, Antonio, Malissen, Bernard, Cazenave, Pierre-André, Pied, Sylviane

Publikováno v: Infection and Immunity
Infection and Immunity, 2015, 84 (1), pp.329-38. ⟨10.1128/IAI.00717-15⟩
Infection and Immunity, American Society for Microbiology, 2015, 84 (1), pp.329-38. ⟨10.1128/IAI.00717-15⟩

International audience; The role of naturally occurring CD4(+) CD25(+) Foxp3(+) regulatory T cells (nTreg) in the pathogenesis of cerebral malaria (CM), which involves both pathogenic T cell responses and parasite sequestration in the brain, is still

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::726f20d15e39d54f9499c7d0627ab179
https://hal-pasteur.archives-ouvertes.fr/pasteur-01491666

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