Zobrazeno 1 - 10
of 54
pro vyhledávání: '"MESH: Piperidines"'
Publikováno v:
Journal of Crohn's and Colitis
Journal of Crohn's and Colitis, Elsevier-Oxford University Press, 2021, 15 (4), pp.695-695. ⟨10.1093/ecco-jcc/jjaa032⟩
Journal of Crohn's and Colitis, Elsevier-Oxford University Press, 2021, 15 (4), pp.695-695. ⟨10.1093/ecco-jcc/jjaa032⟩
International audience; There is a lack of consensus regarding the treatment of inflammatory bowel disease after liver transplantation [LT],1 although some LT patients have responded favourably and safely to biologic therapies such as anti-tumour nec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2718ffaf1c101ecfaffdabea795a3b7c
https://hal.umontpellier.fr/hal-03516226
https://hal.umontpellier.fr/hal-03516226
Autor:
Thomas, Quentin Dominique, Pautas, Marie, Guilhaume, Marie-Noëlle, Fiteni, Fréderic, Ge, Tony, Girard, Nicolas
Publikováno v:
Medicine
Medicine, Lippincott, Williams & Wilkins, 2021, 100 (43), pp.e27611. ⟨10.1097/MD.0000000000027611⟩
Medicine, Lippincott, Williams & Wilkins, 2021, 100 (43), pp.e27611. ⟨10.1097/MD.0000000000027611⟩
International audience; Rationale: Alectinib is a tyrosine kinase inhibitor (TKI) approved for use as first-line metastatic therapy for patients with anaplastic lymphoma kinase-rearranged non-small cell lung cancer. Certain medical conditions related
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4808f870b2ad4e42dc871bf7704c0831
https://hal.archives-ouvertes.fr/hal-03622681/file/Enteral_administration_of_alectinib_for.22.pdf
https://hal.archives-ouvertes.fr/hal-03622681/file/Enteral_administration_of_alectinib_for.22.pdf
Autor:
Yves Dauvilliers, Johan Verbraecken, Markku Partinen, Jan Hedner, Tarja Saaresranta, Ognian Georgiev, Rumen Tiholov, Isabelle Lecomte, Renaud Tamisier, Patrick Lévy, Catherine Scart-Gres, Jeanne-Marie Lecomte, Jean-Charles Schwartz, Jean-Louis Pépin, Valerie Attali, Patrice Bourgin, Frederic Gagnadoux, Farhad Baharloo, Soren Berg, Olli Polo, Jan Anders Hedner, Yeksel Peker, Alexander Blau, Diego Garcia Borreguero, Francisco Javier Puertas Cuesta, Georgi Belev, Yavor Ivanov, Hristo Metev, Diana Petkova, Dejan Dokic, Merita Ismajli Marku, Biserka Jokovska Kaeva, Slavko Jankovic, Ivan Kopitovic, Miodrag Vukcevic
Publikováno v:
American Journal of Respiratory and Critical Care Medicine
American Journal of Respiratory and Critical Care Medicine, American Thoracic Society, 2020, 201 (9), pp.1135-1145. ⟨10.1164/rccm.201907-1284OC⟩
American journal of respiratory and critical care medicine
American Journal of Respiratory and Critical Care Medicine, American Thoracic Society, 2020, 201 (9), pp.1135-1145. ⟨10.1164/rccm.201907-1284OC⟩
American journal of respiratory and critical care medicine
International audience; Rationale: Excessive daytime sleepiness is a common disabling symptom in obstructive sleep apnea syndrome.Objectives: To evaluate the efficacy and safety of pitolisant, a selective histamine H3 receptor antagonist with wake-pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75002b482574fd4cdea4dfe2b7ebf2c4
https://hal.umontpellier.fr/hal-03414861
https://hal.umontpellier.fr/hal-03414861
Autor:
Caroline Protin, Fanny Gallais, Ben Allal, Sandra De Barros, Fabienne Thomas, Anne Quillet-Mary, Melanie White-Koning, Etienne Chatelut, Lucie Oberic, Loïc Dupré, Fabien Despas, Loïc Ysebaert
Publikováno v:
Clinical Pharmacokinetics
Clinical Pharmacokinetics, 2020, 59 (9), pp.1171-1183. ⟨10.1007/s40262-020-00884-0⟩
Clinical Pharmacokinetics, Springer Verlag, 2020, 59 (9), pp.1171-1183. ⟨10.1007/s40262-020-00884-0⟩
Clinical Pharmacokinetics, 2020, 59 (9), pp.1171-1183. ⟨10.1007/s40262-020-00884-0⟩
Clinical Pharmacokinetics, Springer Verlag, 2020, 59 (9), pp.1171-1183. ⟨10.1007/s40262-020-00884-0⟩
Ibrutinib is used for the treatment of chronic lymphocytic leukemia and other lymphoid malignancies. The aim of this work is to develop a population pharmacokinetic model for ibrutinib and its dihydrodiol metabolite to quantify pharmacokinetic inter-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18466632280bd56f9f163b49b4fa5076
https://hal.science/hal-02989879/document
https://hal.science/hal-02989879/document
Publikováno v:
Metabolism
Metabolism, Elsevier, 2020, 103, pp.154027. ⟨10.1016/j.metabol.2019.154027⟩
Metabolism, Elsevier, 2019, 103, pp.154027. ⟨10.1016/j.metabol.2019.154027⟩
Metabolism, 2019, 103, pp.154027. ⟨10.1016/j.metabol.2019.154027⟩
Metabolism, Elsevier, 2020, 103, pp.154027. ⟨10.1016/j.metabol.2019.154027⟩
Metabolism, Elsevier, 2019, 103, pp.154027. ⟨10.1016/j.metabol.2019.154027⟩
Metabolism, 2019, 103, pp.154027. ⟨10.1016/j.metabol.2019.154027⟩
International audience; OBJECTIVE:Glucocorticoids (GCs) are highly effective anti-inflammatory and immunosuppressive drugs. However, prolonged GC therapy may cause numerous adverse effects leading to diabetes and obesity, as well as bone disorders su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47ece87a931db05fd45c2558791704fe
https://hal.archives-ouvertes.fr/hal-02990257
https://hal.archives-ouvertes.fr/hal-02990257
Publikováno v:
Therapeutic Advances in Respiratory Disease
Therapeutic Advances in Respiratory Disease, SAGE Publishing, 2019, 13, pp.175346661983190. ⟨10.1177/1753466619831906⟩
Therapeutic Advances in Respiratory Disease, Vol 13 (2019)
Therapeutic Advances in Respiratory Disease, 2019, 13, pp.175346661983190. ⟨10.1177/1753466619831906⟩
Therapeutic Advances in Respiratory Disease, SAGE Publishing, 2019, 13, pp.175346661983190. ⟨10.1177/1753466619831906⟩
Therapeutic Advances in Respiratory Disease, Vol 13 (2019)
Therapeutic Advances in Respiratory Disease, 2019, 13, pp.175346661983190. ⟨10.1177/1753466619831906⟩
International audience; Molecular profiling of metastatic nonsquamous non-small cell lung cancer (NSCLC) is required to guide the treatment strategy. Anaplastic lymphoma kinase ( ALK) gene rearrangements are found in approximately 5% of lung adenocar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16feb3bb6fbc9a2854a212bfcc4c6927
https://pubmed.ncbi.nlm.nih.gov/30786826
https://pubmed.ncbi.nlm.nih.gov/30786826
Autor:
Janko Kos, Anja Pišlar, Xavier Brazzolotto, Marko Jukič, Stanislav Gobec, Jacques-Philippe Colletier, Nicolas Coquelle, Simon Žakelj, Florian Nachon, Janez Mravljak, Damijan Knez, Matej Sova
Publikováno v:
European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, 2018, 156, pp.598-617. ⟨10.1016/j.ejmech.2018.07.033⟩
European Journal of Medicinal Chemistry, Elsevier, 2018, 156, pp.598-617. ⟨10.1016/j.ejmech.2018.07.033⟩
European Journal of Medicinal Chemistry, 2018, 156, pp.598-617. ⟨10.1016/j.ejmech.2018.07.033⟩
European Journal of Medicinal Chemistry, Elsevier, 2018, 156, pp.598-617. ⟨10.1016/j.ejmech.2018.07.033⟩
International audience; The limited clinical efficacy of current symptomatic treatment and minute effect on progression of Alzheimer's disease has shifted the research focus from single targets towards multi-target-directed ligands. Here, a potent se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cadbcc5e86424f9a1271ee4f83fddd83
https://pubmed.ncbi.nlm.nih.gov/30031971
https://pubmed.ncbi.nlm.nih.gov/30031971
Autor:
Thomas Freret, Véronique Lelong-Boulouard, Pierre Lecouflet, François Dauphin, Katia Hamidouche, Michel Boulouard
Publikováno v:
Psychopharmacology
Psychopharmacology, Springer Verlag, 2017, 234 (15), pp.2365-2374. ⟨10.1007/s00213-017-4664-z⟩
Psychopharmacology, Springer Verlag, 2017, 234 (15), pp.2365-2374. ⟨10.1007/s00213-017-4664-z⟩
It is widely assumed that the upcoming therapeutics for Alzheimer’s disease will require to act on more than one target to be effective. We investigated here whether a combination of the nicotinic receptor allosteric modulator/cholinesterase inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7807a009be755f6ab4c1595b14028578
https://hal-normandie-univ.archives-ouvertes.fr/hal-02135214
https://hal-normandie-univ.archives-ouvertes.fr/hal-02135214
Autor:
Marie Bienvenu-Perrard, Anne-Cécile Paepegaey, Najiba Lahlou, Lionel Groussin, Estelle Louiset, Léopoldine Bricaire, Béatrix Cochand-Priollet, Marco Alifano, Nelly Burnichon, Pierre-Olivier Sarfati
Publikováno v:
Thyroid
Thyroid, Mary Ann Liebert, 2017, 27 (4), pp.587-590. ⟨10.1089/thy.2016.0334⟩
Thyroid, Mary Ann Liebert, 2017, 27 (4), pp.587-590. ⟨10.1089/thy.2016.0334⟩
Medullary thyroid carcinomas (MTCs) complicated by ectopic Cushing's syndrome (CS) have a poor prognosis, partially due to the difficulty in controlling hypercortisolism by adrenal blocking drugs. Recent reports (including the initial follow-up of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::781afc5b5aeaf3e785d3f2927c05161e
https://hal-normandie-univ.archives-ouvertes.fr/hal-01945860
https://hal-normandie-univ.archives-ouvertes.fr/hal-01945860
Autor:
Rahman, Anisur, Lamberty, Yves, Schenker, Esther, Cella, Massimo, Languille, Solène, Bordet, Régis, Richardson, Jill, Pifferi, Fabien, Aujard, Fabienne
Publikováno v:
PLoS ONE
PLoS ONE, Public Library of Science, 2017, 12 (9), pp.e0184822. ⟨10.1371/journal.pone.0184822⟩
PLoS ONE, Vol 12, Iss 9, p e0184822 (2017)
PLoS ONE, 2017, 12 (9), pp.e0184822. ⟨10.1371/journal.pone.0184822⟩
PLoS ONE, Public Library of Science, 2017, 12 (9), pp.e0184822. ⟨10.1371/journal.pone.0184822⟩
PLoS ONE, Vol 12, Iss 9, p e0184822 (2017)
PLoS ONE, 2017, 12 (9), pp.e0184822. ⟨10.1371/journal.pone.0184822⟩
International audience; The development of novel therapeutics to prevent cognitive decline of Alzheimer's disease (AD) is facing paramount difficulties since the translational efficacy of rodent models did not resulted in better clinical results. Cur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a5b74e29145b18039d08a2d3175427a8
https://pubmed.ncbi.nlm.nih.gov/28922421
https://pubmed.ncbi.nlm.nih.gov/28922421