Výsledky vyhledávání - "MESH: Phosphinic Acids"

A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential

Autor: Delphine Rigault, Francine Acher, Nadia Oueslati, Hervé Daniel, Marianne Amalric, Isabelle Brabet, Jean-Philippe Pin, Heather McLean, Hugues-Olivier Bertrand, Tiphanie Courtiol, Bruno Vilar, Thomas Bessiron, Cyril Goudet, Thierry Deltheil

Publikováno v: FASEB Journal
FASEB Journal, Federation of American Society of Experimental Biology, 2012, 26 (4), pp.1682-93. ⟨10.1096/fj.11-195941⟩
FASEB Journal, 2012, 26 (4), pp.1682-93. ⟨10.1096/fj.11-195941⟩
FASEB Journal, Federation of American Society of Experimental Biology, 2012, 26 (4), pp.1682-93. 〈10.1096/fj.11-195941〉

International audience; Metabotropic glutamate (mGlu) receptors are promising targets to treat numerous brain disorders. So far, allosteric modulators are the only subtype selective ligands, but pure agonists still have strong therapeutic potential.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8983843f27bc58d9bb94a0657cb437b2
https://ora.ox.ac.uk/objects/uuid:ef698f81-75c9-4a7c-865a-379868656d73

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Alleviating Pain Hypersensitivity through Activation of Type 4 Metabotropic Glutamate Receptor

Autor: Alain Eschalier, Eric Chapuy, Bruno Vilar, Lauriane Ulmann, Cyril Goudet, Jean-Philippe Pin, Emmanuel Bourinet, Bing Ling, Fanny Malhaire, Sophie Laffray, Francine Acher, Jérôme Busserolles, Youssef Aissouni, Monique Etienne

Publikováno v: Journal of Neuroscience
Journal of Neuroscience, 2013, 33 (48), pp.18951-18965. ⟨10.1523/JNEUROSCI.1221-13.2013⟩
Journal of Neuroscience, Society for Neuroscience, 2013, 33 (48), pp.18951-18965. ⟨10.1523/JNEUROSCI.1221-13.2013⟩

International audience; Hyperactivity of the glutamatergic system is involved in the development of central sensitization in the pain neuraxis, associated with allodynia and hyperalgesia observed in patients with chronic pain. Herein we study the abi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eaa53522c464b5eb057d56363b4f09d
https://hal.science/hal-02448295/document

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Synergy between L-DOPA and a novel positive allosteric modulator of metabotropic glutamate receptor 4: implications for Parkinson's disease treatment and dyskinesia

Autor: Lydia Kerkerian-Le Goff, Dario Doller, Christophe Melon, Khaled-Ezaheir Bennouar, Maria D. Bacolod, Hermogenes N. Jimenez, Paolo Gubellini, Manuel Cajina, Michelle A. Uberti

Publikováno v: Neuropharmacology
Neuropharmacology, 2013, 66, pp.158-69. ⟨10.1016/j.neuropharm.2012.03.022⟩
Neuropharmacology, Elsevier, 2013, 66, pp.158-69. ⟨10.1016/j.neuropharm.2012.03.022⟩

Group III metabotropic glutamate (mGlu) receptors are localized in presynaptic terminals within basal ganglia (BG) circuitry that become hyperactive due to dopamine depletion in Parkinson's disease (PD). For this reason, group III mGlu receptors, in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::130c4170b8541db9c1b59a920fbb96ba
https://pubmed.ncbi.nlm.nih.gov/22491024

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GABA(B) receptor activation triggers BDNF release and promotes the maturation of GABAergic synapses

Autor: Jean-Luc Gaiarsa, Hervé Fiorentino, Menelas N. Pangalos, Nicola Kuczewski, Nadine Ferrand, Christophe Porcher, Diabe Diabira

Publikováno v: Journal of Neuroscience
Journal of Neuroscience, Society for Neuroscience, 2009, 29 (37), pp.11650-61. ⟨10.1523/JNEUROSCI.3587-09.2009⟩

GABA, the main inhibitory neurotransmitter in the adult brain, has recently emerged as an important signal in network development. Most of the trophic functions of GABA have been attributed to depolarization of the embryonic and neonatal neurons via

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94b2037d0c53cc59791dfcb56afb4666
https://pubmed.ncbi.nlm.nih.gov/19759312

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Matrix metalloproteinase inhibition protects rat livers from prolonged cold ischemia-warm reperfusion injury

Autor: Athanasios Yiotakis, Pierre-Michel Huet, Laurent Devel, Virginie Defamie, Antoine Brault, Marina Laurens, Damiano Patrono, Dominique Crenesse, Jean Gugenheim, Pascal Barbry, Bernard Mari, Marie-Christine Saint-Paul, Vincent Dive

Publikováno v: Hepatology
Hepatology, Wiley-Blackwell, 2008, 47 (1), pp.177-85. ⟨10.1002/hep.21929⟩
Hepatology, 2008, 47 (1), pp.177-85. ⟨10.1002/hep.21929⟩

Matrix metalloproteinases (MMPs) have been implicated in the hepatic injury induced after cold ischemia-warm reperfusion (CI-WR), by altering the extracellular matrix (ECM), but their precise role remains unknown. The hepatic MMP expression was evalu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c032ff79432b7366a24b692732138031
https://hal.archives-ouvertes.fr/hal-00315635

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L-(+)-2-Amino-4-thiophosphonobutyric acid (L-thioAP4), a new potent agonist of group III metabotropic glutamate receptors: increased distal acidity affords enhanced potency

Autor: Jean-Philippe Pin, Nadia Oueslati, Chelliah Selvam, Francine Acher, Cyril Goudet

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2007, 50 (19), pp.4656-64. ⟨10.1021/jm070400y⟩
Journal of Medicinal Chemistry, American Chemical Society, 2007, 50 (19), pp.4656-64. 〈10.1021/jm070400y〉
Journal of Medicinal Chemistry, 2007, 50 (19), pp.4656-64. ⟨10.1021/jm070400y⟩

International audience; L-2-Amino-4-phosphonobutyric acid (l-AP4), l-2-amino-4-thiophosphonobutyric acid (l-thioAP4), and l-2-amino-4-(hydroxy)phosphinylbutyric acid (desmethylphosphinothricin, DMPT) were synthesized from protected vinylglycine. They

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b0e50c8558d57965e62d303600c7f96
https://www.hal.inserm.fr/inserm-00318965/document

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