Výsledky vyhledávání - "MESH: Pharmacological Processes"

Fisher information matrix for nonlinear mixed effects multiple response models: evaluation of the appropriateness of the first order linearization using a pharmacokinetic/pharmacodynamic model

Autor: Caroline Bazzoli, Sylvie Retout

Publikováno v: Statistics in Medicine
Statistics in Medicine, Wiley-Blackwell, 2009, 28 (14), pp.1940-56. ⟨10.1002/sim.3573⟩

International audience; We focus on the Fisher information matrix used for design evaluation and optimization in nonlinear mixed effects multiple response models. We evaluate the appropriateness of its expression computed by linearization as proposed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21f6ace1860ead9ddec17de8d83968e8
https://pubmed.ncbi.nlm.nih.gov/19266541

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