Ordered Phosphorylation Events in Two Independent Cascades of the PTEN C-tail Revealed by NMR

Autor: Elouan Terrien, Muriel Delepierre, Alain Chaffotte, Nicolas Wolff, Christophe Prehaud, François-Xavier Theillet, Henri Buc, Monique Lafon, Florence Cordier

Publikováno v: Journal of the American Chemical Society
Journal of the American Chemical Society, American Chemical Society, 2012, 134 (50), pp.20533-20543. ⟨10.1021/ja310214g⟩
Journal of the American Chemical Society, 2012, 134 (50), pp.20533-20543. ⟨10.1021/ja310214g⟩

International audience; PTEN phosphatase is a tumor suppressor controlling notably cell growth, proliferation and survival. The multisite phosphorylation of the PTEN C-terminal tail regulates PTEN activity and intracellular trafficking. The dynamical

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https://hal-pasteur.archives-ouvertes.fr/pasteur-02883989