Výsledky vyhledávání - "MESH: PDZ Domains"

Adaptive landscape flattening in amino acid sequence space for the computational design of protein:peptide binding

Autor: Thomas Simonson, Francesco Villa, Nicolas Panel, Xingyu Chen

Publikováno v: Journal of Chemical Physics
Journal of Chemical Physics, American Institute of Physics, 2018, 149 (7), pp.072302. ⟨10.1063/1.5022249⟩

International audience; For the high throughput design of protein:peptide binding, one must explore a vast space of amino acid sequences in search of low binding free energies. This complex problem is usually addressed with either simple heuristic sc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bacfcd013a2ab009841d86812aef832
https://pubmed.ncbi.nlm.nih.gov/30134674

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Structural Characterization of Whirlin Reveals an Unexpected and Dynamic Supramodule Conformation of Its PDZ Tandem

Autor: Christine Petit, Florent Delhommel, Benjamin Bardiaux, Julia Chamot-Rooke, Michael Nilges, Sébastien Brier, Florence Cordier, Amel Bahloul, Bertrand Raynal, Sylvie Nouaille, Nicolas Wolff, Baptiste Colcombet-Cazenave, Guillaume Bouvier

Publikováno v: Structure
Structure, Elsevier (Cell Press), 2017, 25 (11), pp.1645-1656.e5. ⟨10.1016/j.str.2017.08.013⟩
Structure, 2017, 25 (11), pp.1645-1656.e5. ⟨10.1016/j.str.2017.08.013⟩

International audience; Hearing relies on the transduction of sound-evoked vibrations into electric signals, occurring in the stereocilia bundle of hair cells. The bundle is organized in a staircase pattern formed by rows of packed stereocilia. This

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf6c0f0829c16de0cf89456ba92ad039
https://hal-pasteur.archives-ouvertes.fr/pasteur-02883914

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1H, 13C and 15N backbone resonance assignments and dynamic properties of the PDZ tandem of Whirlin

Autor: Florence Cordier, Nicolas Wolff, Florent Delhommel

Publikováno v: Biomolecular NMR Assignments
Biomolecular NMR Assignments, Springer, 2016, 10 (2), pp.361-365. ⟨10.1007/s12104-016-9701-z⟩
Biomolecular NMR Assignments, 2016, 10 (2), pp.361-365. ⟨10.1007/s12104-016-9701-z⟩

International audience; Mammals perceive sounds thanks to mechanosensory hair cells located in the inner ear. The stereocilia of these cells are tightly bound together in bundles by a network of cadherins and scaffolding proteins. Stereocilia deflect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1aec6f36ec693bff9d4ead6a2825369
https://hal-pasteur.archives-ouvertes.fr/pasteur-02883932

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Quantifying domain-ligand affinities and specificities by high-throughput holdup assay

Publikováno v: Nature Methods
Nature Methods, Nature Publishing Group, 2015, 12 (8), pp.787-793. ⟨10.1038/nmeth.3438⟩
Nature Methods, Nature Publishing Group, 2015, 12 (8), pp.787-U154. ⟨10.1038/NMETH.3438⟩
Nature Methods, 2015, 12 (8), pp.787-793. ⟨10.1038/nmeth.3438⟩
Nature methods

Many protein interactions are mediated by small linear motifs interacting specifically with defined families of globular domains. Quantifying the specificity of a motif requires measuring and comparing its binding affinities to all its putative targe

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https://hal-pasteur.archives-ouvertes.fr/pasteur-02883959

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Strategies to interfere with PDZ-mediated interactions in neurons: What we can learn from the rabies virus

Autor: Elouan Terrien, Nicolas Babault, Nicolas Wolff, Monique Lafon, Florence Cordier, Pierre Maisonneuve, Célia Caillet-Saguy, Florent Delhommel

Publikováno v: Progress in Biophysics and Molecular Biology
Progress in Biophysics and Molecular Biology, 2015, 119 (1), pp.53-59. ⟨10.1016/j.pbiomolbio.2015.02.007⟩
Progress in Biophysics and Molecular Biology, Elsevier, 2015, 119 (1), pp.53-59. ⟨10.1016/j.pbiomolbio.2015.02.007⟩

International audience; PDZ (PSD-95/Dlg/ZO-1) domains play a major role in neuronal homeostasis in which they act as scaffold domains regulating cellular trafficking, self-association and catalytic activity of essential proteins such as kinases and p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14e560c6e268ef1f044c3a5c84f2a93b
https://pubmed.ncbi.nlm.nih.gov/25748547

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Regulation of the catalytic activity of the human phosphatase PTPN4 by its PDZ domain

Autor: Alain Chaffotte, Henri Buc, Nicolas Wolff, Javier Pérez, Muriel Delepierre, Bernard Gilquin, Bertrand Raynal, Pierre Maisonneuve, Célia Caillet-Saguy, Sophie Zinn-Justin, Florence Cordier

Publikováno v: FEBS Journal
FEBS Journal, Wiley, 2014, 281 (21), pp.4852-4865. ⟨10.1111/febs.13024⟩
FEBS Journal, 2014, 281 (21), pp.4852-4865. ⟨10.1111/febs.13024⟩

The human protein tyrosine phosphatase non-receptor type 4 (PTPN4) prevents cells death. Targeting its PDZ domain abrogates this protection and triggers apoptosis. We demonstrate here that the PDZ domain inhibits the phosphatase activity of PTPN4. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb992ee779c4cbf09beff1c9a6ee9bbd
https://hal.archives-ouvertes.fr/hal-02545802

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The mechanism of binding of the second PDZ domain from the Protein Tyrosine Phosphatase-BL to the Adenomatous Polyposis Coli tumor suppressor

Autor: Eva Di Silvio, Stefano Gianni, Angela Morrone, Daniela Bonetti, Angelo Toto

Publikováno v: Protein Engineering, Design and Selection
Protein Engineering, Design and Selection, Oxford University Press (OUP), 2014, 27 (8), pp.249-53. ⟨10.1093/protein/gzu022⟩

International audience; Many biological processes are regulated by the interaction between protein domains and their corresponding binding partners. The PDZ domain is one of the most common protein-protein interaction modules in mammalian cells, whos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e827a3f3ff3ffd19d62807e484683b8f
https://hal-riip.archives-ouvertes.fr/pasteur-01181359/document

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Interference with the PTEN-MAST2 Interaction by a Viral Protein Leads to Cellular Relocalization of PTEN

Autor: Muriel Delepierre, Nicolas Wolff, Zakir Khan, Monique Lafon, Henri Buc, Mireille Lafage, Elouan Terrien, Florence Cordier, Alain Chaffotte, Catherine Simenel, Christophe Prehaud

Publikováno v: Science Signaling
Science Signaling, 2012, 5 (237), pp.ra58-ra58. ⟨10.1126/scisignal.2002941⟩
Science Signaling, American Association for the Advancement of Science, 2012, 5 (237), pp.ra58-ra58. ⟨10.1126/scisignal.2002941⟩

International audience; PTEN (phosphatase and tensin homolog deleted on chromosome 10) and MAST2 (microtubule-associated serine and threonine kinase 2) interact with each other through the PDZ domain of MAST2 (MAST2-PDZ) and the carboxyl-terminal (C-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d935b97cfc47fe71634deb45f7f7532e
https://hal-pasteur.archives-ouvertes.fr/pasteur-02883992

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Interactions outside the boundaries of the canonical binding groove of a pdz domain influence ligand binding

Autor: Åke Engström, Jakob Dogan, Per Jemth, Stefano Gianni, Serena Rinaldo, Patrik Lundström, Francesca Cutruzzolà, Celestine N. Chi, S. Raza Haq

Publikováno v: Biochemistry
Biochemistry, American Chemical Society, 2012, 51 (44), pp.8971-9. ⟨10.1021/bi300792h⟩

The postsynaptic density protein-95/discs large/zonula occludens-1 (PDZ) domain is a protein-protein interaction module with a shallow binding groove where protein ligands bind. However, interactions that are not part of this canonical binding groove

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88f6e9456ab06c4c6aba15e4d3d5da8b
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-186213

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Peptides Targeting the PDZ Domain of PTPN4 Are Efficient Inducers of Glioblastoma Cell Death

Autor: Mireille Lafage, Joseph J.B. Cockburn, Monique Lafon, Christophe Prehaud, Nicolas Wolff, Ahmed Haouz, Florence Cordier, Nicolas Babault, Félix A. Rey, Henri Buc, Muriel Delepierre

Publikováno v: Structure
Structure, 2011, 19 (10), pp.1518-1524. ⟨10.1016/j.str.2011.07.007⟩
Structure, Elsevier (Cell Press), 2011, 19 (10), pp.1518-1524. ⟨10.1016/j.str.2011.07.007⟩

Comment in : PDZ-peptide complexes: as exciting as ever./ Trave G. Structure. 2011 Oct 12;19(10):1350-1. doi: 10.1016/j.str.2011.09.008.PMID: 22000506; International audience; PTPN4, a human tyrosine phosphatase, protects cells against apoptosis. Thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e0e24e66b3993e6d468e4653dff6a72
https://hal-pasteur.archives-ouvertes.fr/pasteur-02883997

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