Glucose Starvation or Pyruvate Dehydrogenase Activation Induce a Broad, ERK5-Mediated, Metabolic Remodeling Leading to Fatty Acid Oxidation

Autor: Abrar Ul Haq Khan, Hamideh Salehi, Catherine Alexia, Jose M. Valdivielso, Milica Bozic, Isabel C. Lopez-Mejia, Lluis Fajas, Sabine Gerbal-Chaloin, Martine Daujat-Chavanieu, Delphine Gitenay, Martin Villalba

Publikováno v: Cells; Volume 11; Issue 9; Pages: 1392
Cells
Cells, 2022, 11 (9), pp.1392. ⟨10.3390/cells11091392⟩

International audience; Cells have metabolic flexibility that allows them to adapt to changes in substrate availability. Two highly relevant metabolites are glucose and fatty acids (FA), and hence, glycolysis and fatty acid oxidation (FAO) are key me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc3cb496b51244ececfd514217231527

Actin reduction by MsrB2 is a key component of the cytokinetic abscission checkpoint and prevents tetraploidy

Autor: Arnaud Echard, Hugo Wioland, Frédérique Cuvelier, Guillaume Romet-Lemonne, Tamara Advedissian, Jian Bai

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2020, 117 (8), pp.4169-4179. ⟨10.1073/pnas.1911629117⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2020, 117 (8), pp.4169-4179. ⟨10.1073/pnas.1911629117⟩
Proc Natl Acad Sci U S A

International audience; Abscission is the terminal step of cytokinesis leading to the physical separation of the daughter cells. In response to the abnormal presence of lagging chromatin between dividing cells, an evolutionarily conserved abscission/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5139df330b93d415d9a12ca7d187948c
https://doi.org/10.1073/pnas.1911629117

IL-15 improves skeletal muscle oxidative metabolism and glucose uptake in association with increased respiratory chain supercomplex formation and AMPK pathway activation

Autor: David A. Patten, Céline Aguer, Marc Foretz, Léa Garneau, Lucien Nadeau, Le Bris S. Quinn, E.E. Pistilli, Michael W. McBurney, Barbara G. Anderson, P. Haddad, Audrey Caron, Mary-Ellen Harper, E. Pinault-Masson, Karen Jardine

Publikováno v: Biochimica et Biophysica Acta (BBA)-General Subjects
Biochimica et Biophysica Acta (BBA)-General Subjects, Elsevier, 2019, 1863 (2), pp.395-407. ⟨10.1016/j.bbagen.2018.10.021⟩

Background IL-15 is believed to play a role in the beneficial impact of exercise on muscle energy metabolism. However, previous studies have generally used supraphysiological levels of IL-15 that do not represent contraction-induced IL-15 secretion.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5465d0c40d36258a8c1390cbf83742b
https://doi.org/10.1016/j.bbagen.2018.10.021

Cysteine oxidation and disulfide formation in the ribosomal exit tunnel

Autor: Schulte, Linda, Mao, Jiafei, Reitz, Julian, Sreeramulu, Sridhar, Kudlinzki, Denis, Hodirnau, Victor-Valentin, Meier-Credo, Jakob, Saxena, Krishna, Buhr, Florian, Langer, Julian D., Blackledge, Martin, Frangakis, Achilleas S., Glaubitz, Clemens, Schwalbe, Harald

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.5569. ⟨10.1038/s41467-020-19372-x⟩
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications, 2020, 11 (1), pp.5569. ⟨10.1038/s41467-020-19372-x⟩

Understanding the conformational sampling of translation-arrested ribosome nascent chain complexes is key to understand co-translational folding. Up to now, coupling of cysteine oxidation, disulfide bond formation and structure formation in nascent c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56a2fecabdb0052809f19c3a012a7acd
https://hal.univ-grenoble-alpes.fr/hal-03119733

Redox signaling in the pathogenesis of human disease and the regulatory role of autophagy

Autor: Gregory Lucien Bellot, Catherine Brenner, Antoinette Lemoine, Shazib Pervaiz

Publikováno v: International Review of Cell and Molecular Biology
International Review of Cell and Molecular Biology, 352, pp.189-214, 2020, ⟨10.1016/bs.ircmb.2020.03.002⟩

International audience; Aberrant cell death signaling and oxidative stress are implicated in myriad of human pathological states such as neurodegenerative, cardiovascular, metabolic and liver diseases, as well as drug-induced toxicities. While regula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acfb5689742cf65cd17e2c4a6ce9f855
https://doi.org/10.1016/bs.ircmb.2020.03.002