Výsledky vyhledávání - "MESH: Oxadiazoles"

Design, Synthesis, and Efficacy Testing of Nitroethylene- and 7-Nitrobenzoxadiazol-Based Flavodoxin Inhibitors against Helicobacter pylori Drug-Resistant Clinical Strains and in Helicobacter pylori -Infected Mice

Autor: Salillas, Sandra, Alías, Miriam, Michel, Valérie, Mahía, Alejandro, Lucía, Ainhoa, Rodrigues, Liliana, Bueno, Jessica, Galano-Frutos, Juan José, de Reuse, Hilde, Velázquez-Campoy, Adrián, Carrodeguas, José Alberto, Sostres, Carlos, Castillo, Javier, Aínsa, José Antonio, Díaz-De-Villegas, María Dolores, Lanas, Angel, Touati, Eliette, Sancho, Javier

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2019, 62 (13), pp.6102-6115. ⟨10.1021/acs.jmedchem.9b00355⟩
Journal of Medicinal Chemistry, 2019, 62 (13), pp.6102-6115. ⟨10.1021/acs.jmedchem.9b00355⟩

International audience; Helicobacter pylori (Hp) infection is the main cause of peptic ulcer and gastric cancer. Hp eradication rates have fallen due to increasing bacterial resistance to currently used broad-spectrum antimicrobials. We have designed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::13de81b0b0f8b52a52f5338646c837b1
https://hal-pasteur.archives-ouvertes.fr/pasteur-02868148

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Autor: Angel Lanas, Eliette Touati, Jessica Bueno, Hilde De Reuse, Liliana Rodrigues, J. Castillo, Miriam Alías, José A. Aínsa, Javier Sancho, Adrián Velázquez-Campoy, Alejandro Mahía, Sandra Salillas, Ainhoa Lucía, Carlos Sostres, María D. Díaz-de-Villegas, Juan J. Galano-Frutos, Valérie Michel, José Alberto Carrodeguas

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2019, 62 (13), pp.6102-6115. ⟨10.1021/acs.jmedchem.9b00355⟩
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Helicobacter pylori (Hp) infection is the main cause of peptic ulcer and gastric cancer. Hp eradication rates have fallen due to increasing bacterial resistance to currently used broad-spectrum antimicrobials. We have designed, synthesized, and teste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e850d663d7b8057cada3c251140cf5cf
https://hal-pasteur.archives-ouvertes.fr/pasteur-02868148

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Bacteriophage Sf6 Tailspike Protein for Detection of Shigella flexneri Pathogens

Autor: Kunstmann, Sonja, Scheidt, Tom, Buchwald, Saskia, Helm, Alexandra, Mulard, Laurence A., Fruth, Angelika, Barbirz, Stefanie

Publikováno v: Viruses
Viruses, MDPI, 2018, 10 (8), pp.431. ⟨10.3390/v10080431⟩
Viruses, Vol 10, Iss 8, p 431 (2018)
Viruses, 2018, 10 (8), pp.431. ⟨10.3390/v10080431⟩

International audience; Bacteriophage research is gaining more importance due to increasing antibiotic resistance. However, for treatment with bacteriophages, diagnostics have to be improved. Bacteriophages carry adhesion proteins, which bind to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::b73ac4f22e36f25a48e566dca1a5cb4b
https://hal-pasteur.archives-ouvertes.fr/pasteur-02043351/file/viruses-10-00431.pdf

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Complete recovery of olfactory associative learning by activation of 5-HT4 receptors after dentate granule cell damage in rats

Autor: M. Migliorati, Evelyne Marchetti, François S. Roman, Emmanuel Nivet, Hélène Jeltsch, Marlyse Jacquet, Jean-Christophe Cassel

Publikováno v: Neurobiology of Learning and Memory
Neurobiology of Learning and Memory, Elsevier, 2008, 90 (1), pp.185-191. ⟨10.1016/j.nlm.2008.03.010⟩
Neurobiology of Learning and Memory, Elsevier, 2008, 90 (1), pp.185-91. ⟨10.1016/j.nlm.2008.03.010⟩
Neurobiology of Learning and Memory, 2008, 90 (1), pp.185-191. ⟨10.1016/j.nlm.2008.03.010⟩
Neurobiology of Learning and Memory, 2008, 90 (1), pp.185-91. ⟨10.1016/j.nlm.2008.03.010⟩

Bilateral intradentate injections of 3.0 μg of colchicine induced a substantial loss of granule cells and damage to the overlying pyramidal cell layer in region CA1 in adult male Long-Evans rats. All rats with such lesions showed a significant assoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d75e4c3aa62df0520685e0f2ee05ff83
https://hal.archives-ouvertes.fr/hal-02347419

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Inhibition of secreted phospholipase A2. 4-glycerol derivatives of 4,5-dihydro-3-(4-tetradecyloxybenzyl)-1,2,4-4H-oxadiazol-5-one with broad activities

Autor: Mohamed Touaibia, Atimé Djimdé, Fei Cao, Eric Boilard, Sofiane Bezzine, Gérard Lambeau, Catherine Redeuilh, Aazdine Lamouri, France Massicot, François Chau, Chang-Zhi Dong, Françoise Heymans

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2007, 50 (7), pp.1618-26. ⟨10.1021/jm060082n⟩

Secreted phospholipases A2 (sPLA2s) have been reported to play an important role in various inflammatory conditions and thus represent an attractive therapeutic target. Previous SAR studies from our laboratory have revealed certain important features

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f45d463521ddcbdf1b76b9d6429099d
https://pubmed.ncbi.nlm.nih.gov/17335183

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Serotonin Transporter Inhibitors Protect against Hypoxic Pulmonary Hypertension

Autor: Minh Hien Pham, Anne Nosjean, Bernadette Raffestin, Serge Adnot, Michel Hamon, Saadia Eddahibi, Elisabeth Marcos

Publikováno v: American Journal of Respiratory and Critical Care Medicine
American Journal of Respiratory and Critical Care Medicine, American Thoracic Society, 2003, 168 (4), pp.487-493. ⟨10.1164/rccm.200210-1212OC⟩
American Journal of Respiratory and Critical Care Medicine, 2003, 168 (4), pp.487-493. ⟨10.1164/rccm.200210-1212OC⟩

International audience; Pulmonary hypertension (PH) results from constriction and remodeling of pulmonary vessels. Serotonin contributes to both phenomena through different signaling pathways. The mitogenic effect of serotonin on pulmonary vascular s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd9f394d26693b767cf3b27f2c02d5d
https://hal.archives-ouvertes.fr/hal-03300325

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Level of haem oxygenase does not obligatorily reflect the sensitivity of PC12 cells to an oxidative shock induced by glutathione depletion

Autor: Albertine, Leon, Isabelle, Le Foll, Christiane, Charriault-Marlangue, Jérome, Leprince, Hubert, Vaudry, Cécilia, Gabriel, Dominique, Duval

Publikováno v: Journal of Neurochemistry
Journal of Neurochemistry, Wiley, 2003, 84 (3), pp.459-70

International audience; In order to investigate the function of haem oxygenase in neuronal cell death or survival, we have determined in PC12 cells whether induction of haem oxygenase mRNA and protein or inhibition of haem oxygenase activity may be a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ae7a97e0ffc806aa0d9570dff19724b2
https://hal-normandie-univ.archives-ouvertes.fr/hal-01962822

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GR 127935 reduces basal locomotor activity and prevents RU 24969-, but not D-amphetamine-induced hyperlocomotion, in the Wistar-Kyoto hyperactive (WKHA) rat

Autor: Hélène Courvoisier, Pierre Mormède, Marie-Pierre Moisan, Francis Chaouloff

Publikováno v: Psychopharmacology
Psychopharmacology, Springer Verlag, 1999, 141 (3), pp.326-331. ⟨10.1007/s002130050841⟩

International audience; The hyperlocomotor effect of the serotonin (5-HT)1A,B receptor agonist 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole (RU 24969) has been repeatedly reported. However, 5-HT1A receptors, 5-HT1B receptors (or both) have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cb451bae7e8fcd3968b1db7111e42f3
https://pubmed.ncbi.nlm.nih.gov/10027515

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Developmental changes in the chemosensitivity of rat brain synaptoneurosomes to excitatory amino acids, estimated by inositol phosphate formation

Autor: Isabelle Sassetti, Max Récasens, Janique Guiramand

Publikováno v: International Journal of Developmental Neuroscience
International Journal of Developmental Neuroscience, Elsevier, 1989, 7 (3), pp.257-66. ⟨10.1016/0736-5748(89)90030-0⟩

International audience; The evolution of excitatory amino acids-(EAA) stimulated inositol phosphates (IPs) turnover during postnatal development was investigated in synaptoneurosomes prepared from rat forebrains. The two main EAA agonists which induc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87184098aa6545eb80d4dd50de343693
https://hal.archives-ouvertes.fr/hal-00422135

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K+ differentially affects the excitatory amino acids- and carbachol-elicited inositol phosphate formation in rat brain synaptoneurosomes

Autor: Max Récasens, Agnès Nourigat, Isabelle Sassetti, Janique Guiramand

Publikováno v: Neuroscience Letters
Neuroscience Letters, Elsevier, 1989, 98 (2), pp.222-228. ⟨10.1016/0304-3940(89)90514-4⟩

International audience; K+, excitatory amino acids (EAAs) and carbachol (Carb) were tested separately or in pairs for their ability to stimulate inositol phosphate (IPs) formation in rat forebrain synaptoneurosomes. K+ ions per se, stimulate IPs synt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee676213d54437794c28ef4dda2e4607
https://hal.archives-ouvertes.fr/hal-00422134

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