TMPRSS2:ERG gene fusion expression regulates bone markers and enhances the osteoblastic phenotype of prostate cancer bone metastases

Autor: Rachel Deplus, Martine Duterque-Coquillaud, Anne Flourens, Edith Bonnelye, Nathalie Vanpouille, Tian V. Tian, Philippe Clézardin, Anais Fradet, Carine Delliaux, Xavier Leroy, Yvan de Launoit, Mathilde Bouchet, Arnauld Villers

Publikováno v: Cancer Letters
Cancer Letters, Elsevier, 2018, 438, pp.32-43. ⟨10.1016/j.canlet.2018.08.027⟩
Cancer Letters, 2018, 438, pp.32-43. ⟨10.1016/j.canlet.2018.08.027⟩

International audience; Abstract : Prostate cancers have a strong propensity to metastasize to bone and promote osteoblastic lesions. TMPRSS2:ERG is the most frequent gene rearrangement identified in prostate cancer, but whether it is involved in pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2efdc0696479c6db9b921256206c223
https://doi.org/10.1016/j.canlet.2018.08.027

Identification of novel recurrent ETV6-IgH fusions in primary central nervous system lymphoma

Autor: Dominique Figarella-Branger, Franck Bielle, Clovis Adam, Louis Royer-Perron, Guillaume Gauchotte, David Meyronet, Aurélie Bruno, Chiara Villa, Amithys Rahimian, Blandine Boisselier, Carole Soussain, Fabrice Chrétien, Khê Hoang-Xuan, Caroline Houillier, Sandrine Eimer, Mailys Daniau, Frederic Davi, Karima Mokhtari, Karim Labreche, Justine Guegan, Pierre de la Grange, Agusti Alentorn, Marc Polivka, Audrey Rousseau, Frédéric Lemoine

Publikováno v: Neuro-Oncology
Neuro-Oncology, 2018, 20 (8), pp.1092-1100. ⟨10.1093/neuonc/noy019⟩
Neuro-Oncology, Oxford University Press (OUP), 2018, 20 (8), pp.1092-1100. ⟨10.1093/neuonc/noy019⟩

International audience; Background: Primary central nervous system lymphoma (PCNSL) represents a particular entity within non-Hodgkin lymphomas and is associated with poor outcome. The present study addresses the potential clinical relevance of chime

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5cc9f95aaa08e9662341fc6bbe9c176
https://hal-pasteur.archives-ouvertes.fr/pasteur-02862388

EWS-FLI1 inhibits TNFα-induced NFκB-dependent transcription in Ewing sarcoma cells

Autor: Christian Auclair, Franck Tirode, Olivier Delattre, Alain Lilienbaum, Julie Lagirand-Cantaloube, Marie-Hélène Kryszke, Karine Laud

Publikováno v: Biochemical and Biophysical Research Communications
Biochemical and Biophysical Research Communications, Elsevier, 2010, 399 (4), pp.705-10. ⟨10.1016/j.bbrc.2010.08.004⟩
Biochemical and Biophysical Research Communications, Elsevier, 2010, 399 (4), pp.705-10. 〈10.1016/j.bbrc.2010.08.004〉

International audience; Ewing sarcoma is primarily caused by a t(11;22) chromosomal translocation encoding the EWS-FLI1 fusion protein. To exert its oncogenic function, EWS-FLI1 acts as an aberrant transcription factor, broadly altering the gene expr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::941e3a632b3037b2f736a357273979c4
https://doi.org/10.1016/j.bbrc.2010.08.004

HOX11L2/TLX3 is transcriptionally activated through T-cell regulatory elements downstream of BCL11B as a result of the t(5;14)(q35;q32)

Autor: Virginie Penard-Lacronique, Isabelle André-Schmutz, Xin-Ying Su, Roland Berger, Paola Ballerini, Claudie Lemercier, Véronique Della-Valle, Francine Mugneret, Serge Romana, Michel Lessard, Isabelle Radford-Weiss, Marina Lafage-Pochitaloff, Olivier Bernard

Publikováno v: Blood
Blood, American Society of Hematology, 2006, 108 (13), pp.4198-201. 〈10.1182/blood-2006-07-032953〉
Blood, 2006, 108 (13), pp.4198-201. ⟨10.1182/blood-2006-07-032953⟩
Blood, American Society of Hematology, 2006, 108 (13), pp.4198-201. ⟨10.1182/blood-2006-07-032953⟩

International audience; The t(5;14)(q35;q32) chromosomal translocation is specifically observed in up to 20% of childhood T-cell acute lymphoblastic leukemia (T-ALL). It affects the BCL11B/CTIP2 locus on chromosome 14 and the RANBP17-TLX3/HOX11L2 reg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6adf14ef0ddfbe9642775c149090b90
https://doi.org/10.1182/blood-2006-07-032953

Detection of the TMPRSS2-ETS fusion gene in prostate carcinomas: retrospective analysis of 55 formalin-fixed and paraffin-embedded samples with clinical data

Autor: Cécile Rouzier, Jean Amiel, Jean-François Michiels, Laure Valério, Juliette Haudebourg, Florence Pedeutour, Xavier Carpentier

Publikováno v: Cancer Genetics and Cytogenetics
Cancer Genetics and Cytogenetics, Elsevier, 2008, 183 (1), pp.21-7. ⟨10.1016/j.cancergencyto.2008.01.021⟩

The recent identification of fusion genes involving ETS family members in human prostate adenocarcinoma has confirmed the hypothesis that recurrent specific aberrations such as fusion genes may be as frequent in epithelial tumors as they are in leuke

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0bf795160ad39ee9d5a9eaa0b7ad358
https://doi.org/10.1016/j.cancergencyto.2008.01.021