A strategy to analyze the phenotypic consequences of inhibiting the association of an RNA-binding protein with a specific RNA.: Targeted inhibition of RNA-protein interaction

Autor: Luc Paillard, Marie Cibois, Audrey Vallée, Carole Gautier-Courteille

Publikováno v: RNA
RNA, Cold Spring Harbor Laboratory Press, 2010, 16 (1), pp.10-5. ⟨10.1261/rna.1742610⟩

International audience; Targeted inactivations of RNA-binding proteins (RNA-BPs) can lead to huge phenotypical defects. These defects are due to the deregulation of certain mRNAs. However, we generally do not know, among the hundreds of mRNAs that ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d47a816081fbabfa8adc23acced1162
https://doi.org/10.1261/rna.1742610

Targeted inhibition of the hepatitis C internal ribosomal entry site genomic RNA with oligonucleotide conjugates

Autor: Reynald Gillet, Bertrand Carboni, Brice Felden, Valérie Guerniou, Fabienne Berrée

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2007, 35 (20), pp.6778-87. ⟨10.1093/nar/gkm770⟩
Nucleic Acids Research, 2007, 35 (20), pp.6778-87. ⟨10.1093/nar/gkm770⟩

International audience; Hepatitis C is a major public health concern, with an estimated 170 million people infected worldwide and an urgent need for new drug development. An attractive therapeutic approach is to prevent the 'cap-independent' translat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::256dea817bb8ecd04421a1585b486e09
http://europepmc.org/articles/PMC2175329

A Critical Role for Calponin 2 in Vascular Development

Autor: Jian Ping Jin, Nathan Bahary, Vikas P. Sukhatme, Guang Hu, Bernard Thisse, Leonard I. Zon, Jenna L. Galloway, Jian Tang, Ganesh Yadlapalli, Sonia Sinha, Jun-ichi Hanai, Yanfeng Lin, Bo Zhang, Christine Thisse

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2006, 281 (10), pp.6664-72. ⟨10.1074/jbc.M506991200⟩

International audience; Calponin 2 (h2 calponin, CNN2) is an actin-binding protein implicated in cytoskeletal organization. We have found that the expression of calponin 2 is relatively restricted to vasculature from 16 to 30 h post-fertilization dur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fad7de1a7b995669db44137277bf6b57
https://doi.org/10.1074/jbc.m506991200

Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesity

Autor: Laetitia Corset, Ralf Jockers, Virginie Vauthier, Aude Lenain, Philippe Froguel, Julie Dam, Yves Rouillé, Patty Chen, Jacques Mallet, Cyril Couturier, Chamsy Sarkis, Sandrine Belouzard, Karin Séron, A Dubart

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2007, 104 (49), pp.19476-81. ⟨10.1073/pnas.0706671104⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2007, 104 (49), pp.19476-81. ⟨10.1073/pnas.0706671104⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2007, 104 (49), pp.19476-81. 〈10.1073/pnas.0706671104〉

Obesity is a major public health problem and is often associated with type 2 diabetes mellitus, cardiovascular disease, and metabolic syndrome. Leptin is the crucial adipostatic hormone that controls food intake and body weight through the activation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cfcbeb046da278e3108a645db41bc7b
https://www.hal.inserm.fr/inserm-00326136

Reduced levels of survival motor neuron protein leads to aberrant motoneuron growth in a Xenopus model of muscular atrophy

Autor: Odile Bronchain, Aurélie Jadaud, Elodie Paillard, Albert Chesneau, Chantal Ballagny, Nicolas Pollet, André Mazabraud, Qods Ymlahi-Ouazzani

Publikováno v: neurogenetics
neurogenetics, Springer Verlag, 2010, 11 (1), pp.27-40. ⟨10.1007/s10048-009-0200-6⟩
neurogenetics, 2010, 11 (1), pp.27-40. ⟨10.1007/s10048-009-0200-6⟩

International audience; Spinal muscular atrophy (SMA) is a neurodegenerative disease characterized by motor neuron loss and skeletal muscle atrophy. The loss of function of the smn1 gene, the main supplier of survival motor neuron protein (SMN) prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddddf595e1f8d65db3634bea5bc26876
https://hal.archives-ouvertes.fr/hal-00506551