In vitro and in vivo pharmacological characterization of ethyl-4-[trans-4-[((2S)-2-hydroxy-3-[4-hydroxy-3[(methylsulfonyl)amino]-phenoxy]propyl) amino]cyclohexyl]benzoate hydrochloride (SAR150640), a new potent and selective human beta3-adrenoceptor agonist for the treatment of preterm labor

Autor: Croci, Tiziano, Cecchi, Roberto, Marini, Pietro, Rouget, Céline, Viviani, Nunzia, Germain, Guy, Guagnini, Fabio, Fradin, Yvon, Descamps, Laurence, Pascal, Marc, Advenier, Charles, Breuiller-Fouché, Michelle, Leroy, Marie-Josèphe, Bardou, Marc

Publikováno v: Journal of Pharmacology and Experimental Therapeutics
Journal of Pharmacology and Experimental Therapeutics, American Society for Pharmacology and Experimental Therapeutics, 2007, 321 (3), pp.1118-26. ⟨10.1124/jpet.106.119123⟩
Journal of Pharmacology and Experimental Therapeutics, American Society for Pharmacology and Experimental Therapeutics, 2007, 321 (3), pp.1118-26. 〈10.1124/jpet.106.119123〉
Journal of Pharmacology and Experimental Therapeutics, 2007, 321 (3), pp.1118-26. ⟨10.1124/jpet.106.119123⟩

International audience; Ethyl-4-[trans-4-[((2S)-2-hydroxy-3-[4-hydroxy-3[(methylsulfonyl)amino] phenoxy]propyl) amino]cyclohexyl]benzoate hydrochloride (SAR150640) was characterized as a new potent and selective beta(3)-adrenoceptor agonist for the t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::365736cea0a91c161381a8feb73de113
https://www.hal.inserm.fr/inserm-00171797/document

Regulation of the endothelin/endothelin receptor system by interleukin-1{beta} in human myometrial cells

Autor: Michelle Breuiller-Fouché, Marie-Josèphe Leroy, Catherine Morinière, Emmanuelle Dallot, R. Rebourcet, Stéphanie Oger, Dominique Cabrol

Publikováno v: Endocrinology
Endocrinology, 2005, 146 (11), pp.4878-86. ⟨10.1210/en.2005-0250⟩
Endocrinology, Endocrine Society, 2005, 146 (11), pp.4878-86. ⟨10.1210/en.2005-0250⟩
Endocrinology, Endocrine Society, 2005, 146 (11), pp.4878-86. 〈10.1210/en.2005-0250〉

Proinflammatory cytokines produced at the fetomaternal interface, such as IL-1beta, have been implicated in preterm and term labor. The present study was performed to evaluate the influence of IL-1beta on the endothelin (ET)/ET receptor system in hum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f613932d34f87086a9ce136c61adb9b5
https://www.hal.inserm.fr/inserm-00171764

Beta3-adrenoceptor is the predominant beta-adrenoceptor subtype in human myometrium and its expression is up-regulated in pregnancy

Autor: Michelle Breuiller-Fouché, E. Naline, T. Croci, Marc Bardou, Marie-Josèphe Leroy, C. Loustalot, H. Qi, C. Rouget, Dominique Cabrol, C. Advenier

Publikováno v: Journal of Clinical Endocrinology and Metabolism
Journal of Clinical Endocrinology and Metabolism, Endocrine Society, 2005, 90 (3), pp.1644-50. 〈10.1210/jc.2004-0233〉
Journal of Clinical Endocrinology and Metabolism, 2005, 90 (3), pp.1644-50. ⟨10.1210/jc.2004-0233⟩
Journal of Clinical Endocrinology and Metabolism, Endocrine Society, 2005, 90 (3), pp.1644-50. ⟨10.1210/jc.2004-0233⟩

International audience; To assess whether pregnancy might influence the functionality and expression of human myometrial beta(2)- and beta(3)-adrenoceptors (beta(2)- and beta(3)-AR), we performed functional, binding, Western blot, and molecular biolo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ef649e87049e0b085d8c42f91cf8a0a
http://www.hal.inserm.fr/inserm-00171792/document

Anti-inflammatory and utero-relaxant effects in human myometrium of new generation phosphodiesterase 4 inhibitors

Autor: Mary S. Barnette, Céline Méhats, Stéphanie Oger, Françoise Ferré, Marie-Josèphe Leroy, Dominique Cabrol

Publikováno v: Biology of Reproduction
Biology of Reproduction, Society for the Study of Reproduction, 2004, 70 (2), pp.458-64. ⟨10.1095/biolreprod.103.023051⟩
Biology of Reproduction, Society for the Study of Reproduction, 2004, 70 (2), pp.458-64. 〈10.1095/biolreprod.103.023051〉

International audience; The anti-inflammatory and utero-relaxant effects of two potent phosphodiesterase 4 (PDE4) inhibitors of the latest generation: cilomilast (one of the most advanced PDE4 inhibitors in clinical development, reportedly more selec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a63a8b445f8277f5e8696a8578b9107
https://www.hal.inserm.fr/inserm-00321998/file/458.pdf

A functional genomic study to identify differential gene expression in the preterm and term human myometrium

Autor: Charpigny, Gilles, Leroy, Marie-Josèphe, Breuiller-Fouché, Michelle, Tanfin, Zarha, Mhaouty-Kodja, Sakina, Robin, Philippe, Leiber, Denis, Cohen-Tannoudji, Joëlle, Cabrol, Dominique, Barberis, Claude, Germain, Guy

Publikováno v: Biology of Reproduction
Biology of Reproduction, Society for the Study of Reproduction, 2003, 68 (6), pp.2289-96. 〈10.1095/biolreprod.102.013763〉
Biology of Reproduction, 2003, 68 (6), pp.2289-96. ⟨10.1095/biolreprod.102.013763⟩
Biology of Reproduction, Society for the Study of Reproduction, 2003, 68 (6), pp.2289-96. ⟨10.1095/biolreprod.102.013763⟩

International audience; The mechanisms that lead to the onset of human parturition are still unknown, although selected critical factors have been identified. To investigate the changes in myometrial gene expression associated with parturition, we us

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::61c198e109db61da5d7429d33ad1e804
http://www.hal.inserm.fr/inserm-00322053/file/2289.pdf