Zobrazeno 1 - 10
of 22
pro vyhledávání: '"MESH: Mitogen-Activated Protein Kinase Kinases"'
Autor:
Mylène Tajan, Marianne Mus, Thomas Edouard, Karine Tréguer, Jean-Pierre Salles, Alexandra Montagner, Armelle Yart, Patrick Raynal, Toshiyuki Araki, M. Tauber, Philippe Valet, Audrey De Rocca Serra-Nédélec, Marie Dance, Benjamin G. Neel
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America 11 (109), 4257-4262. (2012)
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2012, 109 (11), pp.4257-62. ⟨10.1073/pnas.1119803109⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2012, 109 (11), pp.4257-4262. ⟨10.1073/pnas.1119803109⟩
Proceedings of the National Academy of Sciences of the United States of America, 2012, 109 (11), pp.4257-4262. ⟨10.1073/pnas.1119803109⟩
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2012, 109 (11), pp.4257-62. ⟨10.1073/pnas.1119803109⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2012, 109 (11), pp.4257-4262. ⟨10.1073/pnas.1119803109⟩
Proceedings of the National Academy of Sciences of the United States of America, 2012, 109 (11), pp.4257-4262. ⟨10.1073/pnas.1119803109⟩
Noonan syndrome (NS), a genetic disease caused in half of cases by activating mutations of the tyrosine phosphatase SHP2 ( PTPN11 ), is characterized by congenital cardiopathies, facial dysmorphic features, and short stature. How mutated SHP2 induces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b331c42273a01c5f8af7d797ede56951
http://prodinra.inra.fr/record/387290
http://prodinra.inra.fr/record/387290
Publikováno v:
Biochemical and Biophysical Research Communications
Biochemical and Biophysical Research Communications, 2010, 394 (3), pp.453-8. ⟨10.1016/j.bbrc.2009.11.163⟩
Biochemical and Biophysical Research Communications, Elsevier, 2010, 394 (3), pp.453-8. ⟨10.1016/j.bbrc.2009.11.163⟩
Biochemical and Biophysical Research Communications, 2010, 394 (3), pp.453-8. ⟨10.1016/j.bbrc.2009.11.163⟩
Biochemical and Biophysical Research Communications, Elsevier, 2010, 394 (3), pp.453-8. ⟨10.1016/j.bbrc.2009.11.163⟩
International audience; Peroxisome proliferator-activated receptor gamma (PPARgamma) ligands have been shown to possess anti-proliferative effects in many types of cancer. In clear cell renal cell carcinoma (CCRCC), the targets involved in these effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f68296ae19518903c6b0238f23fcd5e
https://www.hal.inserm.fr/inserm-00439619
https://www.hal.inserm.fr/inserm-00439619
Autor:
Rita Guzun, Michael Zaugg, Malgorzata Tokarska-Schlattner, Eliana Lucchinetti, Séverine Gratia, Uwe Schlattner, Laurence Kay, Valdur Saks
Publikováno v:
AJP-Regulatory, Integrative and Comparative Physiology
AJP-Regulatory, Integrative and Comparative Physiology, American Physiological Society, 2010, 298 (4), pp.R1075-88. ⟨10.1152/ajpregu.00360.2009⟩
AJP-Regulatory, Integrative and Comparative Physiology, American Physiological Society, 2010, 298 (4), pp.R1075-88. ⟨10.1152/ajpregu.00360.2009⟩
International audience; Doxorubicin (DXR) belongs to the most efficient anticancer drugs. However, its clinical application is limited by the risk of severe cardiac-specific toxicity, for which an efficient treatment is missing. Underlying molecular
Publikováno v:
Journal of Integrative Neuroscience
Journal of Integrative Neuroscience, World Scientific Publishing, 2008, 7 (2), pp.249-70. ⟨10.1142/s0219635208001800⟩
Journal of Integrative Neuroscience, World Scientific Publishing, 2008, 7 (2), pp.249-70. ⟨10.1142/s0219635208001800⟩
International audience; In this report, we elucidate by use of microelectrode arrays novel forms of long-term depression and potentiation in the hippocampus which are triggered by low frequency afferent stimulation and which rely on the activation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51201779e22f3e95304b0ba5cf788790
https://hal.archives-ouvertes.fr/hal-00624666
https://hal.archives-ouvertes.fr/hal-00624666
Autor:
Cédric Filipe, Stephanie Lehoux, Chantal Dessy, Audrey Billon, Laetitia Lam Shang Leen, Pierre Gourdy, Jean-François Arnal, Vincent Benouaich, Laurent Brouchet, Alain Tedgui, Alain-Pierre Gadeau, Henrik Laurell, Jean-Luc Balligand
Publikováno v:
American Journal of Pathology
American Journal of Pathology, American Society for Investigative Pathology, 2008, 172 (3), pp.830-8. ⟨10.2353/ajpath.2008.070439⟩
The American Journal of Pathology : cellular and molecular biology of disease, Vol. 172, no. 3, p. 830-838 (2008)
American Journal of Pathology, American Society for Investigative Pathology, 2008, 172 (3), pp.830-8. ⟨10.2353/ajpath.2008.070439⟩
The American Journal of Pathology : cellular and molecular biology of disease, Vol. 172, no. 3, p. 830-838 (2008)
We have previously shown that estrogen exerts a vasoprotective effect by accelerating reendothelialization after perivascular artery injury through activation of the estrogen receptor alpha. Because 17beta-estradiol (E2) is known to increase the bioa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59d6f6a95719639e49c389e02289a8f6
https://hal.archives-ouvertes.fr/hal-00287606/file/Billon_et_al_AmJPathol2008_accept_version.pdf
https://hal.archives-ouvertes.fr/hal-00287606/file/Billon_et_al_AmJPathol2008_accept_version.pdf
Publikováno v:
Blood
Blood, American Society of Hematology, 2008, 111 (4), pp.1913-23. ⟨10.1182/blood-2007-07-099218⟩
Blood, American Society of Hematology, 2008, 111 (4), pp.1913-23. ⟨10.1182/blood-2007-07-099218⟩
Fanconi anemia (FA), an inherited syndrome that associates bone marrow failure, cancer predisposition, and genetic instability, is characterized by an overproduction of the myelosuppressive cytokine TNF-alpha through unknown mechanisms. We demonstrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c70fe7b032fc80c4f6e89fde52485aee
https://hal.archives-ouvertes.fr/hal-00282475
https://hal.archives-ouvertes.fr/hal-00282475
Publikováno v:
Cell Host and Microbe
Cell Host and Microbe, 2007, 1 (1), pp.77-83. ⟨10.1016/j.chom.2007.02.002⟩
Cell Host and Microbe, Elsevier, 2007, 1 (1), pp.77-83. ⟨10.1016/j.chom.2007.02.002⟩
Cell Host and Microbe, 2007, 1 (1), pp.77-83. ⟨10.1016/j.chom.2007.02.002⟩
Cell Host and Microbe, Elsevier, 2007, 1 (1), pp.77-83. ⟨10.1016/j.chom.2007.02.002⟩
International audience; Many bacteria pathogenic for plants or animals, including Shigella spp., which is responsible for shigellosis in humans, use a type III secretion apparatus to inject effector proteins into host cells. Effectors alter cell sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23c98895b6f2bc560689f34a81234ceb
https://hal-pasteur.archives-ouvertes.fr/pasteur-01540876/document
https://hal-pasteur.archives-ouvertes.fr/pasteur-01540876/document
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2006, 103 (16), pp.6386-91. ⟨10.1073/pnas.0510691103⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2006, 103 (16), pp.6386-91. ⟨10.1073/pnas.0510691103⟩
Environmental cues modulate a variety of intracellular pathways whose signaling is integrated by the molecular mechanism that constitutes the circadian clock. Although the essential gears of the circadian machinery have been elucidated, very little i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b95e157f4e9c0706d0246e54d989bc1
https://hal.archives-ouvertes.fr/hal-00188235
https://hal.archives-ouvertes.fr/hal-00188235
Autor:
Falluel-Morel, Anthony, Aubert, Nicolas, Vaudry, David, Basille, Magali, Fontaine, Marc, Fournier, Alain, Vaudry, Hubert, Gonzalez, Bruno J
Publikováno v:
Journal of Neurochemistry
Journal of Neurochemistry, Wiley, 2004, 91 (5), pp.1231-43. ⟨10.1111/j.1471-4159.2004.02810.x⟩
Journal of Neurochemistry, Wiley, 2004, 91 (5), pp.1231-43. ⟨10.1111/j.1471-4159.2004.02810.x⟩
International audience; The sphingomyelin-derived messenger ceramides provoke neuronal apoptosis through caspase-3 activation, while the neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) promotes neuronal survival and inhibits c
Publikováno v:
Current Biology-CB
Current Biology-CB, Elsevier, 2005, 15 (1), pp.19-23. ⟨10.1016/j.cub.2004.12.037⟩
Current Biology-CB, Elsevier, 2005, 15 (1), pp.19-23. ⟨10.1016/j.cub.2004.12.037⟩
International audience; Eukaryotic initiation factor 4E (eIF4E) controls a crucial step of translation initiation and is critical for cell growth . Biochemical studies have shown that it undergoes a regulated phosphorylation by the MAP-kinase signal-