Zobrazeno 1 - 10
of 69
pro vyhledávání: '"MESH: Mitogen-Activated Protein Kinase 1"'
Autor:
Thomas Bertero, Catherine Rucker-Martin, David Montani, Laurent Tesson, Marc Humbert, Fabrice Antigny, Frédéric Perros, Séverine Remy, Véronique Capuano, Barbara Girerd, Ignacio Anegon, Boris Manoury, Christine Péchoux, Olaf Mercier, Mélanie Lambert, Valérie Domergue, Morad K. Nakhleh, Aurélie Hautefort, Angèle Boet
Publikováno v:
Circulation Research
Circulation Research, American Heart Association, 2019, 125 (7), pp.678-695. ⟨10.1161/CIRCRESAHA.119.314793⟩
Circulation Research, 2019, 125 (7), pp.678-695. ⟨10.1161/CIRCRESAHA.119.314793⟩
Circulation Research, American Heart Association, 2019, 125 (7), pp.678-695. ⟨10.1161/CIRCRESAHA.119.314793⟩
Circulation Research, 2019, 125 (7), pp.678-695. ⟨10.1161/CIRCRESAHA.119.314793⟩
Rationale: Pulmonary arterial hypertension is a severe lethal cardiopulmonary disease. Loss of function mutations in KCNK3 (potassium channel subfamily K member 3) gene, which encodes an outward rectifier K + channel, have been identified in pulmonar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb2e5a85d626ceb4ed23c4529ed9583c
https://hal.archives-ouvertes.fr/hal-02346635/document
https://hal.archives-ouvertes.fr/hal-02346635/document
Autor:
Samantha Barichievy, Jerolen Naidoo, Mikaël Boullé, Janine Scholefield, Suraj P. Parihar, Anna K. Coussens, Frank Brombacher, Alex Sigal, Musa M. Mhlanga
Publikováno v:
Frontiers in Cellular and Infection Microbiology
Frontiers in Cellular and Infection Microbiology, Frontiers, 2018, 8, pp.263. ⟨10.3389/fcimb.2018.00263⟩
Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)
Frontiers in Cellular and Infection Microbiology, Frontiers, 2018, 8, pp.263. ⟨10.3389/fcimb.2018.00263⟩
Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)
International audience; An emerging realization of infectious disease is that pathogens can cause a high incidence of genetic instability within the host as a result of infection-induced DNA lesions. These often lead to classical hallmarks of cancer,
Autor:
Ng, Kai-Yu, Chan, Lok-Hei, Chai, Stella, Tong, Man, Guan, Xin-Yuan, Lee, Nikki, Yuan, Yunfei, Xie, Dan, Lee, Terence, Dusetti, Nelson, Carrier, Alice, Ma, Stephanie, Ma, Man, Yuan, Xin-Yuan, Ma, Nelson, Ma, Alice
Publikováno v:
Cancer Research
Cancer Research, American Association for Cancer Research, 2017, 77 (17), pp.4602-4612. ⟨10.1158/0008-5472.CAN-16-3456⟩
Cancer Research, 2017, 77 (17), pp.4602-4612. ⟨10.1158/0008-5472.CAN-16-3456⟩
Cancer Research, American Association for Cancer Research, 2017, 77 (17), pp.4602-4612. ⟨10.1158/0008-5472.CAN-16-3456⟩
Cancer Research, 2017, 77 (17), pp.4602-4612. ⟨10.1158/0008-5472.CAN-16-3456⟩
Identifying critical factors involved in the metastatic progression of hepatocellular carcinoma (HCC) may offer important therapeutic opportunities. Here, we report that the proapoptotic stress response factor TP53INP1 is often selectively downregula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1b57756512413024783ce101c836396
https://hal.archives-ouvertes.fr/hal-01788462
https://hal.archives-ouvertes.fr/hal-01788462
Autor:
Asher Castiel, Asher Shainberg, Hila Milshtein-Parush, Françoise Dantzer, Malka Cohen-Armon, Leonid Visochek, Gayane Grigoryan, A. Kalal, Adva Yeheskel, Marie-France Langelier, Neta Gazit, Rony Seger, Inna Slutsky, John M. Pascal, Menahem Segal
Publikováno v:
Scientific Reports
Scientific Reports, Nature Publishing Group, 2016, 6, pp.24950. ⟨10.1038/srep24950⟩
Scientific Reports, Nature Publishing Group, 2016, 6, pp.24950. ⟨10.1038/srep24950⟩
Unexpectedly, a post-translational modification of DNA-binding proteins, initiating the cell response to single-strand DNA damage, was also required for long-term memory acquisition in a variety of learning paradigms. Our findings disclose a molecula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47ec929087552f6d0f64807d7ac4b954
https://hal.archives-ouvertes.fr/hal-02369918
https://hal.archives-ouvertes.fr/hal-02369918
Autor:
Sarra Chbicheb, Jean-Luc Rodeau, Yves Chapleur, Stéphane Salamone, Stéphane Flament, Michel Boisbrun, Sabine Mazerbourg, Xiao Yao, Isabelle Grillier-Vuissoz, Daniel Spohn, Gerald Thiel
Publikováno v:
Biochemical Pharmacology
Biochemical Pharmacology, Elsevier, 2011, 81 (9), pp.1087. ⟨10.1016/j.bcp.2011.02.006⟩
Biochemical Pharmacology, Elsevier, 2011, 81 (9), pp.1087-1097. ⟨10.1016/j.bcp.2011.02.006⟩
Biochemical Pharmacology, Elsevier, 2011, 81 (9), pp.1087. ⟨10.1016/j.bcp.2011.02.006⟩
Biochemical Pharmacology, Elsevier, 2011, 81 (9), pp.1087-1097. ⟨10.1016/j.bcp.2011.02.006⟩
International audience; Our aim was to get new information about the Peroxisome Proliferator Activated Receptor gamma (PPARγ)-independent pathway involved in the antiproliferative action of PPARγ ligands in breast cancer cells. We investigated the
Autor:
Marc Poirot, Guillaume Amouroux, Loubna Mhamdi, Sandrine Silvente-Poirot, Michael R. Paillasse, Philippe de Medina
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 11, Pp 2203-2211 (2009)
Journal of Lipid Research
Journal of Lipid Research, 2009, 50 (11), pp.2203-11. ⟨10.1194/jlr.M800668-JLR200⟩
Journal of Lipid Research, American Society for Biochemistry and Molecular Biology, 2009, 50 (11), pp.2203-11. ⟨10.1194/jlr.M800668-JLR200⟩
Journal of Lipid Research
Journal of Lipid Research, 2009, 50 (11), pp.2203-11. ⟨10.1194/jlr.M800668-JLR200⟩
Journal of Lipid Research, American Society for Biochemistry and Molecular Biology, 2009, 50 (11), pp.2203-11. ⟨10.1194/jlr.M800668-JLR200⟩
International audience; Several studies indicate that cholesterol esterification is deregulated in cancers. The present study aimed to characterize the role of cholesterol esterification in proliferation and invasion of two tumor cells expressing an
Autor:
Thierry Levade, Frédérique Sabourdy, Nicole Therville, Nathalie Andrieu-Abadie, Anu Jalanko, Virginie Garcia, Claudine Tardy
Publikováno v:
Biochimica et Biophysica Acta-Molecular Cell Research
Biochimica et Biophysica Acta-Molecular Cell Research, 2009, 1793 (7), pp.1250-8. ⟨10.1016/j.bbamcr.2009.03.007⟩
Biochimica et Biophysica Acta-Molecular Cell Research, 2009, 1793 (7), pp.1250-8. ⟨10.1016/j.bbamcr.2009.03.007⟩
International audience; Induction of apoptosis by TNF has recently been shown to implicate proteases from lysosomal origin, the cathepsins. Here, we investigated the role in apoptosis of palmitoyl protein thioesterase 1 (PPT1), another lysosomal enzy
Publikováno v:
Biochemical and Biophysical Research Communications
Biochemical and Biophysical Research Communications, Elsevier, 2008, 372 (4), pp.845-9. ⟨10.1016/j.bbrc.2008.05.135⟩
Biochemical and Biophysical Research Communications, Elsevier, 2008, 372 (4), pp.845-9. ⟨10.1016/j.bbrc.2008.05.135⟩
Mammalian cells express two closely related MEK isoforms, MEK1 and MEK2, upstream of the ERK1/ERK2 MAPK module. Although genetic studies have suggested that MEK1 and MEK2 do not have overlapping functions in vivo, little is known about their specific
Publikováno v:
Molecular and Cellular Biology
Molecular and Cellular Biology, American Society for Microbiology, 2008, 28 (1), pp.511-27. ⟨10.1128/MCB.00800-07⟩
Molecular and Cellular Biology, American Society for Microbiology, 2008, 28 (1), pp.511-27. ⟨10.1128/MCB.00800-07⟩
The proteins ERK1 and ERK2 are highly similar, are ubiquitously expressed, and share activators and substrates; however, erk2 gene invalidation is lethal in mice, while erk1 inactivation is not. We ablated ERK1 and/or ERK2 by RNA interference and exp
Autor:
Jianfeng Liu, Chanjuan Xu, Federica Bertaso, Philippe Rondard, Fangli Cao, Xueying Zhang, Haijun Tu, Jean-Philippe Pin
Publikováno v:
Cellular Signalling
Cellular Signalling, Elsevier, 2007, 19 (9), pp.1996-2002. ⟨10.1016/j.cellsig.2007.05.004⟩
Cellular Signalling, 2007, 19 (9), pp.1996-2002. ⟨10.1016/j.cellsig.2007.05.004⟩
Cellular Signalling, Elsevier, 2007, 19 (9), pp.1996-2002. ⟨10.1016/j.cellsig.2007.05.004⟩
Cellular Signalling, 2007, 19 (9), pp.1996-2002. ⟨10.1016/j.cellsig.2007.05.004⟩
gamma-aminobutyric acid type B (GABA(B)) receptor is an allosteric complex made of two subunits, GABA(B1) and GABA(B2). GABA(B2) plays a major role in the coupling to G protein whereas GABA(B1) binds GABA. It has been shown that GABA(B) receptor acti