Mutated CCDC51 Coding for a Mitochondrial Protein, MITOK Is a Candidate Gene Defect for Autosomal Recessive Rod-Cone Dystrophy

Autor: Steven B. Blanchard, Cécile Méjécase, Thierry Léveillard, Sandra Chantot-Bastaraud, Marion Neuillé, Christelle Michiels, Saddek Mohand-Said, Elise Orhan, Christina Zeitz, Juliette Wohlschlegel, Frédéric Blond, Audrey Schalk, Sébastien Augustin, Christel Condroyer, Amrit Estivalet, Lisa Emmenegger, Aline Antonio, Vanessa Démontant, Crystel Bonnet, José-Alain Sahel, Camille Andrieu, Isabelle Audo, Marine Foussard

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 15
International Journal of Molecular Sciences, 2021, 22 (15), pp.7875. ⟨10.3390/ijms22157875⟩
International Journal of Molecular Sciences, Vol 22, Iss 7875, p 7875 (2021)

The purpose of this work was to identify the gene defect underlying a relatively mild rod-cone dystrophy (RCD), lacking disease-causing variants in known genes implicated in inherited retinal disorders (IRD), and provide transcriptomic and immunoloca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc75b819a0ffb296b4db901df214bc6d

Analysis of diverse eukaryotes suggests the existence of an ancestral mitochondrial apparatus derived from the bacterial type II secretion system

Autor: Alžběta Motyčková, Čestmír Vlček, Vladimír Klimeš, B. Franz Lang, Michael W. Gray, Zuzana Vaitová, Anastasios D. Tsaousis, Tomáš Pánek, Ingrid Guilvout, Marek Eliáš, Romain Derelle, Vojtěch Žárský, Markéta Petrů, Mohamed Chami, Karel Harant, Lenka Horváthová, Jan Pyrih, Olivera Francetic, Luboš Voleman, Pavel Doležal, Lenka Marková, Veronika Klápšťová, Ivan Čepička, Klára Hryzáková, Martina Vinopalová

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.2947. ⟨10.1038/s41467-021-23046-7⟩
Nature Communications, 2021, 12 (1), pp.2947. ⟨10.1038/s41467-021-23046-7⟩
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)

The type 2 secretion system (T2SS) is present in some Gram-negative eubacteria and used to secrete proteins across the outer membrane. Here we report that certain representative heteroloboseans, jakobids, malawimonads and hemimastigotes unexpectedly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b800b20644833bfb7b700b78814074d6
https://hal-pasteur.archives-ouvertes.fr/pasteur-03247185

Listeria monocytogenesexploits the MICOS complex subunit Mic10 to promote mitochondrial fragmentation and cellular infection

Autor: Mariette Matondo, Pascale Cossart, Filipe Carvalho, Fabrizia Stavru, Anna Spier, T. Chaze

Publikováno v: mBio
mBio, American Society for Microbiology, 2020, 11 (1), ⟨10.1128/mBio.03171-19⟩
mBio, 2020, 11 (1), ⟨10.1128/mBio.03171-19⟩

Mitochondrial function adapts to cellular demands and is affected by the ability of the organelle to undergo fusion and fission in response to physiological and non-physiological cues. We previously showed that infection with the human bacterial path

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71e9e3457ca897166d9cfa7bbc722cc9
https://doi.org/10.1101/712067

The Protozoan Parasite Toxoplasma gondii Selectively Reprograms the Host Cell Translatome

Autor: Julie Lorent, Maritza Jaramillo, Laia Masvidal, Tommy Alain, Ola Larsson, Visnu Chaparro, Bruno D. Fonseca, Tyson E. Graber, Léon C van Kempen, Maria Aguirre, Louis-Philippe Leroux

Publikováno v: Infection and Immunity
Infection and Immunity, American Society for Microbiology, 2018, 86 (9), pp.e00244-18. ⟨10.1128/IAI.00244-18⟩
Infection and Immunity, 86(9):ARTN e00244-18. AMER SOC MICROBIOLOGY

International audience; The intracellular parasite Toxoplasma gondii promotes infection by targeting multiple host cell processes; however, whether it modulates mRNA translation is currently unknown. Here, we show that infection of primary murine mac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::615ebb9a78a49ce9a9e41a7e1dacffad
https://doi.org/10.1128/iai.00244-18

Adaptive aneuploidy protects against thiol peroxidase deficiency by increasing respiration via key mitochondrial proteins

Autor: Vadim N. Gladyshev, Maxim V. Gerashchenko, Michel B. Toledano, Inge Seim, Jean Labarre, Alaattin Kaya

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2015, 112 (34), pp.10685-90. ⟨10.1073/pnas.1505315112⟩
Proceedings of the National Academy of Sciences of the United States of America, 2015, 112 (34), pp.10685-90. ⟨10.1073/pnas.1505315112⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2015, 112 (34), pp.10685-90. 〈10.1073/pnas.1505315112〉

International audience; Aerobic respiration is a fundamental energy-generating process; however, there is cost associated with living in an oxygen-rich environment, because partially reduced oxygen species can damage cellular components. Organisms ev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d62c216f758d47b792b39b62ce037a0
https://europepmc.org/articles/PMC4553801/