Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels

Autor: Susan M. Mason, John R. P. Knight, Arnaud Echard, Giuseppina Caligiuri, Dide Reijmer, Monika Calka, Flore Kruiswijk, David Sumpton, David Novo, Karen Blyth, Iain R. Macpherson, Karen H. Vousden, Peter Bailey, Sara Zanivan, Kerstin Klinkert, Jim C. Norman, Judith Secklehner, Amanda MacFarlane, Nikki Heath, Huabing Yin, Jennifer P. Morton, Leo M. Carlin, Louise Mitchell, Ewan J. McGhee, Laura Charlton, Emmanuel Dornier

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Nature Communications
Nature Communications, Nature Publishing Group, 2018, 9 (1), pp.5069. ⟨10.1038/s41467-018-07339-y⟩
Nature Communications, 2018, 9 (1), pp.5069. ⟨10.1038/s41467-018-07339-y⟩
Novo, D, Heath, N, Mitchell, L, Caligiuri, G, MacFarlane, A, Reijmer, D, Charlton, L, Knight, J, Calka, M, McGhee, E, Dornier, E, Sumpton, D, Mason, S, Echard, A, Klinkert, K, Secklehner, J, Kruiswijk, F, Vousden, K, Macpherson, I R, Blyth, K, Bailey, P, Yin, H, Carlin, L M, Morton, J, Zanivan, S & Norman, J C 2018, ' Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels ', Nature Communications, vol. 9, no. 1, 5069 . https://doi.org/10.1038/s41467-018-07339-y

Mutant p53s (mutp53) increase cancer invasiveness by upregulating Rab-coupling protein (RCP) and diacylglycerol kinase-α (DGKα)-dependent endosomal recycling. Here we report that mutp53-expressing tumour cells produce exosomes that mediate intercel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4508e22176087bbcbdf320820985074e
http://link.springer.com/article/10.1038/s41467-018-07339-y

Accurate nanoscale flexibility measurement of DNA and DNA–protein complexes by atomic force microscopy in liquid

Autor: Murugesapillai, Divakaran, Bouaziz, Serge, Maher, L James, Israeloff, Nathan, Cameron, Craig, Williams, Mark, Maher, L. James

Publikováno v: Nanoscale
Nanoscale, 2017, 9 (31), pp.11327-11337. ⟨10.1039/c7nr04231k⟩
Nanoscale, Royal Society of Chemistry, 2017, 9 (31), pp.11327-11337. ⟨10.1039/c7nr04231k⟩

We obtain accurate three-dimensional persistence length measurements for DNA and DNA–protein complexes using liquid AFM imaging, validated by optical tweezers.
The elasticity of double-stranded DNA (dsDNA), as described by its persistence leng

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aac9c781595edd76fbab373c0755b0ca
https://doi.org/10.1039/c7nr04231k

Stromal protein βig-h3 reprogrammes tumour microenvironment in pancreatic cancer

Autor: Goehrig, Delphine, Nigri, Jérémy, Samain, Rémi, Wu, Zhichong, Cappello, Paola, Gabiane, Gaëlle, Zhang, Xinyi, Zhao, Yajie, Kim, In-San, Chanal, Marie, Curto, Roberta, Hervieu, Valerie, de La Fouchardière, Christelle, Novelli, Francesco, Milani, Pascale, Tomasini, Richard, Bousquet, Corinne, Bertolino, Philippe, Hennino, Ana

Publikováno v: Gut
Gut, BMJ Publishing Group, 2019, 68 (4), pp.693-707. ⟨10.1136/gutjnl-2018-317570⟩
Gut, 2019, 68 (4), pp.693-707. ⟨10.1136/gutjnl-2018-317570⟩

Objective Pancreatic cancer is associated with an abundant stromal reaction leading to immune escape and tumour growth. This massive stroma drives the immune escape in the tumour. We aimed to study the impact of βig-h3 stromal protein in the modulat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a57125f8df089a15445caaac9a73f303
https://pubmed.ncbi.nlm.nih.gov/31168443

Spontaneous non-canonical assembly of CcmK hexameric components from β-carboxysome shells of cyanobacteria

Autor: Katharina Root, Eric Lesniewska, Gilles Truan, Nicolas Pocholle, Luis F. Garcia-Alles, Renato Zenobi, Denis Pompon, David Reguera, Nathalie Aubry, Carlos I Mendoza, Konstantin Barylyuk, Eric Bourillot

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2017, 12 (9), 30 p. ⟨10.1371/journal.pone.0185109⟩
PLoS ONE, Public Library of Science, 2017, 12 (9), ⟨10.1371/journal.pone.0185109⟩
PLoS ONE, Vol 12, Iss 9, p e0185109 (2017)
Dipòsit Digital de la UB
Universidad de Barcelona
Plos One 9 (12), 30 p.. (2017)
PLoS ONE, 12 (9)
PLoS ONE, 2017, 12 (9), 30 p. ⟨10.1371/journal.pone.0185109⟩
Recercat. Dipósit de la Recerca de Catalunya
instname

CcmK proteins are major constituents of icosahedral shells of β-carboxysomes, a bacterial microcompartment that plays a key role for CO2 fixation in nature. Supported by the characterization of bidimensional (2D) layers of packed CcmK hexamers in cr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21c3f74e4f6d3cfc4351026c0712e448
https://hal.archives-ouvertes.fr/hal-01886429

Mapping elasticity moduli of atherosclerotic plaque in situ via atomic force microscopy

Autor: Jacques Ohayon, Nicolas Mesnier, Jackub Toczek, Alexis Broisat, Laurent Riou, Philippe Tracqui

Publikováno v: Journal of Structural Biology
Journal of Structural Biology, Elsevier, 2011, 174 (1), pp.115-23. ⟨10.1016/j.jsb.2011.01.010⟩

International audience; Several studies have suggested that evolving mechanical stresses and strains drive atherosclerotic plaque development and vulnerability. Especially, stress distribution in the plaque fibrous capsule is an important determinant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc700f7e635b62152b84fa81d04c7607
https://doi.org/10.1016/j.jsb.2011.01.010