Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels

Autor: Susan M. Mason, John R. P. Knight, Arnaud Echard, Giuseppina Caligiuri, Dide Reijmer, Monika Calka, Flore Kruiswijk, David Sumpton, David Novo, Karen Blyth, Iain R. Macpherson, Karen H. Vousden, Peter Bailey, Sara Zanivan, Kerstin Klinkert, Jim C. Norman, Judith Secklehner, Amanda MacFarlane, Nikki Heath, Huabing Yin, Jennifer P. Morton, Leo M. Carlin, Louise Mitchell, Ewan J. McGhee, Laura Charlton, Emmanuel Dornier

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Nature Communications
Nature Communications, Nature Publishing Group, 2018, 9 (1), pp.5069. ⟨10.1038/s41467-018-07339-y⟩
Nature Communications, 2018, 9 (1), pp.5069. ⟨10.1038/s41467-018-07339-y⟩
Novo, D, Heath, N, Mitchell, L, Caligiuri, G, MacFarlane, A, Reijmer, D, Charlton, L, Knight, J, Calka, M, McGhee, E, Dornier, E, Sumpton, D, Mason, S, Echard, A, Klinkert, K, Secklehner, J, Kruiswijk, F, Vousden, K, Macpherson, I R, Blyth, K, Bailey, P, Yin, H, Carlin, L M, Morton, J, Zanivan, S & Norman, J C 2018, ' Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels ', Nature Communications, vol. 9, no. 1, 5069 . https://doi.org/10.1038/s41467-018-07339-y

Mutant p53s (mutp53) increase cancer invasiveness by upregulating Rab-coupling protein (RCP) and diacylglycerol kinase-α (DGKα)-dependent endosomal recycling. Here we report that mutp53-expressing tumour cells produce exosomes that mediate intercel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4508e22176087bbcbdf320820985074e
http://link.springer.com/article/10.1038/s41467-018-07339-y

TP53INP1 Downregulation Activates a p73-Dependent DUSP10/ERK Signaling Pathway to Promote Metastasis of Hepatocellular Carcinoma

Autor: Ng, Kai-Yu, Chan, Lok-Hei, Chai, Stella, Tong, Man, Guan, Xin-Yuan, Lee, Nikki, Yuan, Yunfei, Xie, Dan, Lee, Terence, Dusetti, Nelson, Carrier, Alice, Ma, Stephanie, Ma, Man, Yuan, Xin-Yuan, Ma, Nelson, Ma, Alice

Publikováno v: Cancer Research
Cancer Research, American Association for Cancer Research, 2017, 77 (17), pp.4602-4612. ⟨10.1158/0008-5472.CAN-16-3456⟩
Cancer Research, 2017, 77 (17), pp.4602-4612. ⟨10.1158/0008-5472.CAN-16-3456⟩

Identifying critical factors involved in the metastatic progression of hepatocellular carcinoma (HCC) may offer important therapeutic opportunities. Here, we report that the proapoptotic stress response factor TP53INP1 is often selectively downregula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1b57756512413024783ce101c836396
https://hal.archives-ouvertes.fr/hal-01788462

Smac mimetic promotes glioblastoma cancer stem-like cell differentiation by activating NF-κB

Autor: Claudia Jennewein, Aurélie Tchoghandjian, Dominique Figarella-Branger, Simone Fulda, Ines Eckhardt, Stefan Momma

Publikováno v: Cell Death and Differentiation
Cell Death and Differentiation, Nature Publishing Group, 2014, 21 (5), pp.735-747. ⟨10.1038/cdd.2013.200⟩
Cell Death and Differentiation, 2014, 21 (5), pp.735-747. ⟨10.1038/cdd.2013.200⟩

International audience; Recently, a broader role of inhibitor of apoptosis (IAP) proteins besides their antiapoptotic functions has been described. Therefore, we investigated the effect of non-toxic concentrations of the small-molecule Smac mimetic B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a981ed3b54be87b0aaf1817d84ba4d0f
https://doi.org/10.1038/cdd.2013.200

Fluticasone Propionate Inhibits Lipopolysaccharide-Induced Proinflammatory Response in Human Cystic Fibrosis Airway Grafts

Autor: Jacky Jacquot, Claire Danel, Caroline Majer-Teboul, Edith Puchelle, Sandie Escotte, Jean-Michel Triglia, Daniel Dusser, Dominique Gaillard, Sylvie Benoit

Publikováno v: Journal of Pharmacology and Experimental Therapeutics
Journal of Pharmacology and Experimental Therapeutics, 2002, 302 (3), pp.1151-7. ⟨10.1124/jpet.102.033407⟩
Journal of Pharmacology and Experimental Therapeutics, American Society for Pharmacology and Experimental Therapeutics, 2002, 302 (3), pp.1151-7. ⟨10.1124/jpet.102.033407⟩
Journal of Pharmacology and Experimental Therapeutics, American Society for Pharmacology and Experimental Therapeutics, 2002, 302 (3), pp.1151-7. 〈10.1124/jpet.102.033407〉

Airway inflammation, one of the major factors leading to lung damage in cystic fibrosis (CF) patients, is associated with an abnormal increase in proinflammatory cytokines. In this work, we demonstrate the increased release of the proinflammatory cyt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96209178da423a433ad8f75ccf49d93b
https://doi.org/10.1124/jpet.102.033407

Troponin-I enhances and is required for oncogenic overgrowth

Autor: Sergio Casas-Tintó, Manuel Serrano, Antonio Maraver, Alberto Ferrús

Publikováno v: Oncotarget
Oncotarget, Impact journals, 2016, 7 (33), pp.52631-52642. ⟨10.18632/oncotarget.10616⟩
Digital.CSIC. Repositorio Institucional del CSIC
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Human tumors of various tissue origins show an intriguing over-expression of genes not considered oncogenes, such as that encoding Troponin-I (TnI), a wellknown muscle protein. Out of the three TnI genes known in humans, the slow form, TNNI1, is affe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b33ec0126ce80d87686da525c9a629c
https://hal.umontpellier.fr/hal-02295297/document