De novo biosynthesis of sterols and fatty acids in the Trypanosoma brucei procyclic form: Carbon source preferences and metabolic flux redistributions

Autor: Millerioux, Yoann, Mazet, Muriel, Bouyssou, Guillaume, Allmann, Stefan, Kiema, Tiila-Riikka, Bertiaux, Eloise, Fouillen, Laetitia, Thapa, Chandan, Biran, Marc, Plazolles, Nicolas, Dittrich-Domergue, Franziska, Crouzols, Aline, Wierenga, Rik, Rotureau, Brice, MOREAU, Patrick, Bringaud, Frédéric

Publikováno v: PLoS Pathogens
PLoS Pathogens, 2018, 14 (5), pp.e1007116. ⟨10.1371/journal.ppat.1007116⟩
PLoS Pathogens, Vol 14, Iss 5, p e1007116 (2018)
Plos Pathogens 5 (14), . (2018)
PLoS Pathogens, Public Library of Science, 2018, 14 (5), pp.e1007116. ⟨10.1371/journal.ppat.1007116⟩

De novo biosynthesis of lipids is essential for Trypanosoma brucei, a protist responsible for the sleeping sickness. Here, we demonstrate that the ketogenic carbon sources, threonine, acetate and glucose, are precursors for both fatty acid and sterol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::cd1c8081112e14bd66e3f9fecd999d02
https://hal-pasteur.archives-ouvertes.fr/pasteur-01849809/file/journal.ppat.1007116.pdf

Aminobisphosphonates Synergize with Human Cytomegalovirus To Activate the Antiviral Activity of Vγ9Vδ2 Cells

Autor: Suzanne Peyrottes, Eric Champagne, Charline Daguzan, Christian Davrinche, Morgane Moulin, Hanna Kulyk-Barbier

Publikováno v: Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2016, 196 (5), pp.2219-2229. ⟨10.4049/jimmunol.1501661⟩
Journal of Immunology, 2016, 196 (5), pp.2219-2229. ⟨10.4049/jimmunol.1501661⟩

Human V gamma 9V delta 2 T cells are activated through their TCR by neighboring cells producing phosphoantigens. Zoledronate (ZOL) treatment induces intracellular accumulation of the phosphoantigens isopentenyl pyrophosphate and ApppI. Few attempts h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bb90cf91f93a97be4d52664ed4c92bf
https://hal.archives-ouvertes.fr/hal-02408121

Membrane remodeling, an early event in benzo[a]pyrene-induced apoptosis

Autor: Laurence Huc, Odile Sergent, Marie-Thérèse Dimanche-Boitrel, Jørn A. Holme, Mary Rissel, Dominique Lagadic-Gossmann, Xavier Tekpli, Daniel Catheline, Philippe Legrand, Vincent Rioux

Publikováno v: Toxicology and Applied Pharmacology
Toxicology and Applied Pharmacology, Elsevier, 2010, 243 (1), pp.68-76. ⟨10.1016/j.taap.2009.11.014⟩
Toxicology and Applied Pharmacology, 2010, 243 (1), pp.68-76. ⟨10.1016/j.taap.2009.11.014⟩

International audience; Benzo[alpha]pyrene (B[alpha]P) often serves as a model for mutagenic and carcinogenic polycyclic aromatic hydrocarbons (PAHs). Our previous work suggested a role of membrane fluidity in B[alpha]P-induced apoptotic process. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9024e2f6cd8655a2363bc54b7ff5e64c
https://hal.archives-ouvertes.fr/hal-00660136

Rsp5p ubiquitin ligase and the transcriptional activators Spt23p and Mga2p are involved in co-regulation of biosynthesis of end products of the mevalonate pathway and triacylglycerol in yeast Saccharomyces cerevisiae

Autor: Thierry Ferreira, Thierry Bergès, Teresa Zołądek, Anna Szkopinska, Pawel Kaliszewski, Ewa Świeżewska

Publikováno v: Biochimica et Biophysica Acta-Molecular Cell Research
Biochimica et Biophysica Acta-Molecular Cell Research, Elsevier, 2008, 1781 (10), pp.627-34. ⟨10.1016/j.bbalip.2008.07.011⟩

International audience; Rsp5p, a yeast S. cerevisiae ubiquitin ligase, is essential for regulation of unsaturated fatty acid synthesis via activation of the transcriptional activators Spt23p and Mga2p. Here we show that the conditional mutant rsp5-19

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::937d5321e79fd99dccea90d61e924c5a
https://hal.archives-ouvertes.fr/hal-00492350