Lung Fibrosis Is Improved by Extracellular Vesicles from IFNγ-Primed Mesenchymal Stromal Cells in Murine Systemic Sclerosis

Autor: Rozier, Pauline, Maumus, Marie, Maria, Alexandre Thibault Jacques, Toupet, Karine, Jorgensen, Christian, Guilpain, Philippe, Noël, Danièle

Publikováno v: Cells
Volume 10
Issue 10
Cells, Vol 10, Iss 2727, p 2727 (2021)
Cells, MDPI, 2021, 10 (10), pp.2727. ⟨10.3390/cells10102727⟩

International audience; Background: Systemic sclerosis (SSc) is a severe autoimmune disease for which mesenchymal stromal cells (MSCs)-based therapy was reported to reduce SSc-related symptoms in pre-clinical studies. Recently, extracellular vesicles

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2622f72de58c8909faf720e3f84a9f69

Extracellular Vesicles Are More Potent Than Adipose Mesenchymal Stromal Cells to Exert an Anti-Fibrotic Effect in an In Vitro Model of Systemic Sclerosis

Autor: Marie Maumus, Pauline Rozier, Florence Sabatier, Danièle Noël, Alexandre Thibault Jacques Maria, Christian Jorgensen, Claire Bony, Philippe Guilpain

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 6837, p 6837 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 13
International Journal of Molecular Sciences, 2021, 22 (13), pp.6837. ⟨10.3390/ijms22136837⟩

International audience; Systemic sclerosis (SSc) is a complex disorder resulting from dysregulated interactions between the three main pathophysiological axes: fibrosis, immune dysfunction, and vasculopathy, with no specific treatment available to da

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6894dd507ed8d6a067531aa142515b1c
https://www.mdpi.com/1422-0067/22/13/6837

The ATP synthase inhibition induces an AMPK-dependent glycolytic switch of mesenchymal stem cells that enhances their immunotherapeutic potential

Autor: Patricia Luz-Crawford, Carolina Pradenas, Farida Djouad, Mauricio Campos-Mora, Maroun Khoury, Karina Oyarce, Noymar Luque-Campos, Maria Jose Torres, María Jose Paredes-Martínez, Yandi Rigual-Gonzalez, Gautier Tejedor, María De Los Ángeles García-Robles, Christian Jorgensen, Roberto Elizondo-Vega, Rafael Contreras-Lopez, Claudia Altamirano, Magdiel Salgado, Ana María Vega-Letter

Publikováno v: Theranostics
Theranostics, 2021, 11 (1), pp.445-460. ⟨10.7150/thno.51631⟩

International audience; Objectives: Mesenchymal Stem/Stromal Cells (MSC) are promising therapeutic tools for inflammatory diseases due to their potent immunoregulatory capacities. Their suppressive activity mainly depends on inflammatory cues that ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::009f9bfaf8138979defb9ee262b160d1
https://pubmed.ncbi.nlm.nih.gov/33391485

TNFα/TNFR2 signaling pathway: an active immune checkpoint for mesenchymal stem cell immunoregulatory function

Autor: Beldi, Ghada, Khosravi, Maryam, Abdelgawad, Mohamed Essameldin, Salomon, Benoît, Uzan, Georges, Haouas, Houda, Naserian, Sina

Publikováno v: Current Stem Cell Research & Therapy
Current Stem Cell Research & Therapy, 2020, 11 (1), pp.281. ⟨10.1186/s13287-020-01740-5⟩
Current Stem Cell Research & Therapy, Bentham Science Publishers Ltd, 2020, 11 (1), pp.281. ⟨10.1186/s13287-020-01740-5⟩
Stem Cell Research & Therapy
Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-15 (2020)

International audience; Background: In addition to their multilineage potential, mesenchymal stem cells (MSCs) have a broad range of functions from tissue regeneration to immunomodulation. MSCs have the ability to modulate the immune response and cha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::cb9bfefa4d9a7f8843fbace9631c832c
https://doi.org/10.1186/s13287-020-01740-5

Rheumatoid Synovial Fluids Regulate the Immunomodulatory Potential of Adipose-Derived Mesenchymal Stem Cells Through a TNF/NF-κB-Dependent Mechanism

Autor: Souraya Sayegh, Oula El Atat, Katy Diallo, Benjamin Rauwel, Yannick Degboé, Etienne Cavaignac, Arnaud Constantin, Alain Cantagrel, Viviane Trak-Smayra, Nada Alaaeddine, Jean-Luc Davignon

Publikováno v: Frontiers in Immunology
Frontiers in Immunology, Vol 10 (2019)
Frontiers in Immunology, 2019, 10, pp.1482. ⟨10.3389/fimmu.2019.01482⟩

International audience; Introduction: Adipose-derived mesenchymal stem cells (ADSC) have been shown to have remarkable immune-modulating effects. However, their efficacy in clinical trials has yet to be fully demonstrated. This could be due to a lack

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::105a9338af9097f15184707f1e63ad29
http://europepmc.org/articles/PMC6710434