APOBEC3A intratumoral DNA electroporation in mice

Autor: Vincent Caval, J Thalmensi, T Bestetti, E Pliquet, L Fiette, M Julithe, T. Huet, Anna Kostrzak, M Escande, Simon Wain-Hobson, Pierre Langlade-Demoyen

Publikováno v: Gene Therapy
Gene Therapy, Nature Publishing Group, 2017, 24 (2), pp.74-83. ⟨10.1038/gt.2016.77⟩
Gene Therapy, 2017, 24 (2), pp.74-83. ⟨10.1038/gt.2016.77⟩

International audience; Human APOBEC3A (A3A) cytidine deaminase shows pro-apoptotic properties resulting from hypermutation of genomic DNA, induction of double-stranded DNA breaks (DSBs) and G1 cell cycle arrest. Given this, we evaluated the antitumo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8487b68fc1c4afe01c1197b742d10a6
https://hal-pasteur.archives-ouvertes.fr/pasteur-02545771

Peroxisome proliferator-activated receptor alpha deficiency impairs regulatory T cell functions: Possible application in the inhibition of melanoma tumor growth in mice

Autor: François Ghiringhelli, Narcisse Zwetyenga, Naim Akhtar Khan, Kabirou Moutairou, Françoise Salvadori, Aziz Hichami, Akadiri Yessoufou

Publikováno v: Biochimie
Biochimie, Elsevier, 2016, 131, pp.1-10. 〈http://www.sciencedirect.com/science/article/pii/S0300908416301687〉. 〈10.1016/j.biochi.2016.09.001〉
Biochimie, Elsevier, 2016, 131, pp.1-10. ⟨10.1016/j.biochi.2016.09.001⟩

International audience; Regulatory T (Treg) cells are important to induce and maintain immunological self-tolerance. Although the progress accomplished in understanding the functional mechanism of Treg cells, intracellular molecules that control the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::680a88628c39b4f4606d36c13f1ca7cc
https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01452771

Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma

Autor: Alvaro C. Laga, John M. Asara, Howard Y. Chang, Justin L. Tan, Brian T. Do, Leonard I. Zon, Anne Bothmer, Richard M. White, David H. Price, Ng Shyh-Chang, Ryan A. Flynn, Nicole Pandell, Song Yang, Violaine Saint-André, Yoon Jung Kim, Zi Peng Fan, Koh Fujinaga, Elliott J. Hagedorn, Serine Avagyan, Tae Hoon Kim, Cristina Santoriello, B. Matija Peterlin, Ellen van Rooijen, John G. Clohessy, John E. Brogie, Richard A. Young, Celeste B. Greer, Yi Zhou, Pier Paolo Pandolfi, Rachel D. Fogley, Julien Ablain

Publikováno v: Molecular Cell
Molecular Cell, 2016, 62 (1), pp.34-46. ⟨10.1016/j.molcel.2016.03.013⟩
Molecular Cell, Elsevier, 2016, 62 (1), pp.34-46. ⟨10.1016/j.molcel.2016.03.013⟩
PMC
Molecular cell, vol 62, iss 1

International audience; Studying cancer metabolism gives insight into tumorigenic survival mechanisms and susceptibilities. In melanoma, we identify HEXIM1, a transcription elongation regulator, as a melanoma tumor suppressor that responds to nucleot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d2be414500e23e7e55cf569d834dacf
https://hal-pasteur.archives-ouvertes.fr/pasteur-02871949

Dacarbazine-mediated upregulation of NKG2D ligands on tumor cells activates NK and CD8 T cells and restrains melanoma growth

Autor: Grégoire Mignot, Alice Hervieu, Cédric Rébé, Lionel Apetoh, Frédérique Végran, Fanny Chalmin, François Ghiringhelli, Mélanie Bruchard, Pierre Vabres

Publikováno v: Journal of Investigative Dermatology
Journal of Investigative Dermatology, Nature Publishing Group, 2013, 133 (2), pp.499-508. ⟨10.1038/jid.2012.273⟩
Journal of Investigative Dermatology, 2013, 133 (2), pp.499-508. ⟨10.1038/jid.2012.273⟩
Journal of Investigative Dermatology, Nature Publishing Group, 2013, 133 (2), pp.499-508. 〈10.1038/jid.2012.273〉

International audience; Dacarbazine (DTIC) is a cytotoxic drug widely used for melanoma treatment. However, the putative contribution of anticancer immune responses in the efficacy of DTIC has not been evaluated. By testing how DTIC affects host immu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8bb5bff821678b5ff52126169d6f5f9
https://www.hal.inserm.fr/inserm-00857892

Intravenous immunoglobulin promotes antitumor responses by modulating macrophage polarization

Autor: Pedro Berraondo, Nico van Rooijen, Ángeles Domínguez-Soto, Mateo de las Casas-Engel, Carmen Sánchez-Torres, David Sancho, Rafael Bragado, Laura Aragoneses-Fenoll, María L. Toribio, José Medina-Echeverz, Silvia Sánchez-Ramón, Pierre Bruhns, María A. Moro, Antonio Castrillo, Angel L. Corbí, Isabel Cuartero, Enrique Martin-Gayo

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2014, 193 (10), pp.5181-5189. ⟨10.4049/jimmunol.1303375⟩
Journal of Immunology, 2014, 193 (10), pp.5181-5189. ⟨10.4049/jimmunol.1303375⟩
Dominguez-Soto, A, de las Casas-Engel, M, Bragado, R, Medina-Echeverz, J, ragoneses-Fenoll, L, Martin-Gayo, E, van Rooijen, N, Berraondo, P, Toribio, M L, Moro, M A, Cuartero, I, Castrillo, A, Sancho, D, Sanchez-Torres, C, Bruhns, P, Sanchez-Ramon, S & Corbi, A L 2014, ' Intravenous Immunoglobulin Promotes Antitumor Responses by Modulating Macrophage Polarization ', Journal of Immunology, vol. 193, no. 10, pp. 5181-5189 . https://doi.org/10.4049/jimmunol.1303375
Journal of Immunology, 193(10), 5181-5189. American Association of Immunologists

et al.
Intravenous Igs (IVIg) therapy is widely used as an immunomodulatory strategy in inflammatory pathologies and is suggested to promote cancer regression. Because progression of tumors depends on their ability to redirect the polarization s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::566460992fa0cc83ffac0d36922cda3a
http://hdl.handle.net/10261/124545