Výsledky vyhledávání - "MESH: Mast Cells / immunology"

House dust mites activate nociceptor–mast cell clusters to drive type 2 skin inflammation

Autor: Mindy Tsai, Camille Petitfils, Nicolas Cenac, Stephen J. Galli, Riccardo Sibilano, Xinzhong Dong, Laurent L. Reber, Nicolas Gaudenzio, Lilian Basso, Philipp Starkl, Nadine Serhan, Chrystelle Bonnart, Thomas Marichal, James Meixiong

Publikováno v: Nature immunology, vol 20, iss 11
Nature Immunology
Nature Immunology, Nature Publishing Group, 2019, 20 (11), pp.1435-1443. ⟨10.1038/s41590-019-0493-z⟩
Nature immunology
Cellular and Molecular Immunology
Nature Immunology, 2019, 20 (11), pp.1435-1443. ⟨10.1038/s41590-019-0493-z⟩

International audience; Allergic skin diseases, such as atopic dermatitis, are clinically characterized by severe itching and type 2 immunity-associated hypersensitivity to widely distributed allergens, including those derived from house dust mites (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9a210f2b72a571a86d44cf7d521c13c
https://doi.org/10.1038/s41590-019-0493-z

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The 'Mast Cell and Basophil Club' of the French Society for Immunology

Autor: Joana Vitte, S. Georgin-Lavialle, Laurent L. Reber, Ulrich Blank, Michel Arock, Nicolas Gaudenzio, Mei Li, Nicolas Charles, Gaël Ménasché

Publikováno v: European Journal of Immunology
European Journal of Immunology, 2020, 50 (10), pp.1430-1431. ⟨10.1002/eji.202070105⟩
European Journal of Immunology, Wiley-VCH Verlag, 2020, 50 (10), pp.1430-1431. ⟨10.1002/eji.202070105⟩

International audience; Mast cells and basophils are best known for their key role during allergic responses [1]. Yet, they also have pivotal functions in innate and acquired (via IgE) defense mechanisms against microbes and parasites as well as in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd6508b4692b7a13b3da7e3d38953594
https://doi.org/10.1002/eji.202070105

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Genetic and Imaging Approaches Reveal Pro-Inflammatory and Immunoregulatory Roles of Mast Cells in Contact Hypersensitivity

Autor: Nicolas Gaudenzio, Thomas Marichal, Stephen J. Galli, Laurent L. Reber

Publikováno v: Frontiers in Immunology
Frontiers in Immunology, Vol 9 (2018)
Frontiers in Immunology, 2018, 9, pp.1275. ⟨10.3389/fimmu.2018.01275⟩
Frontiers in Immunology, Frontiers, 2018, 9, pp.1275. ⟨10.3389/fimmu.2018.01275⟩

International audience; Contact hypersensitivity (CHS) is a common T cell-mediated skin disease induced by epicutaneous sensitization to haptens. Mast cells (MCs) are widely deployed in the skin and can be activated during CHS responses to secrete di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef96c9bd843387b03a512e737d448412
https://doi.org/10.3389/fimmu.2018.01275

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Human mast cells as antigen-presenting cells

Autor: Nicolas Gaudenzio, Stephen J. Galli

Publikováno v: Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology, Elsevier, 2018, 141 (1), pp.92-93. ⟨10.1016/j.jaci.2017.05.029⟩

International audience

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15c226cf675f05f5eac3cfa325ef298b
https://hal-univ-tlse3.archives-ouvertes.fr/hal-03157455

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Human mast cells as antigen-presenting cells: When is this role important in vivo?

Autor: Galli, Stephen, Gaudenzio, Nicolas

Publikováno v: Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology, 2018, 141 (1), pp.92-93. ⟨10.1016/j.jaci.2017.05.029⟩

International audience

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1398::67e6e9290dfb1e2ca5e177e8fdf36359
https://doi.org/10.1016/j.jaci.2017.05.029

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Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling

Autor: Jacob Piehler, Philipp Starkl, Matthew Tiffany, Aaron M. Ring, Stephan Wilmes, Milica Gakovic, Jonathan T. Sockolosky, Stephen J. Galli, K. Christopher Garcia, Akanksha Chhabra, Hye-Sook Kwon, Irving L. Weissman, Chia Chi Ho, Peter-John Schnorr, Judith A. Shizuru, Ignacio Moraga, Tom S. Wehrman, Riccardo Sibilano, Nicolas Gaudenzio

Publikováno v: Cell
Cell, Elsevier, 2017, 168 (6), pp.1041-1052.e18. ⟨10.1016/j.cell.2017.02.011⟩
Cell, 2017, 168 (6), pp.1041-1052.e18. ⟨10.1016/j.cell.2017.02.011⟩

International audience; Most secreted growth factors and cytokines are functionally pleiotropic because their receptors are expressed on diverse cell types. While important for normal mammalian physiology, pleiotropy limits the efficacy of cytokines

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50a1081d8f227b99929621a47f8faaa4
https://hal-univ-tlse3.archives-ouvertes.fr/hal-03375039

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Pathways of immediate hypothermia and leukocyte infiltration in an adjuvant-free mouse model of anaphylaxis

Autor: Philipp Starkl, Riccardo Sibilano, Laurent L. Reber, Hajime Karasuyama, Bianca Balbino, Stephen J. Galli, Pierre Bruhns, Thomas Marichal, Mindy Tsai, Nicolas Gaudenzio

Publikováno v: Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology, Elsevier, 2017, 139 (2), pp.584-596.e10. ⟨10.1016/j.jaci.2016.05.047⟩
Journal of Allergy and Clinical Immunology, 2017, 139 (2), pp.584-596.e10. ⟨10.1016/j.jaci.2016.05.047⟩

Background Conflicting results have been obtained regarding the roles of Fc receptors and effector cells in models of active systemic anaphylaxis (ASA). In part, this might reflect the choice of adjuvant used during sensitization because various adju

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9aa3bc6fe0560e9470ac64a04dde18b
https://hal-pasteur.archives-ouvertes.fr/pasteur-02510918

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A Connective Tissue Mast-Cell-Specific Receptor Detects Bacterial Quorum-Sensing Molecules and Mediates Antibacterial Immunity

Autor: Xinzhong Dong, Nadine Serhan, Ying Zhang, Rebecca Yee, Xueqing Wu, Xintong Dong, Priyanka Pundir, Nathachit Limjunyawong, Solomon H. Snyder, Yingzhuan Zhan, Jorge E. Vidal, Chirag Vasavda, Rui Liu, Nicolas Gaudenzio

Publikováno v: Cell Host & Microbe
Cell Host & Microbe, 2019, 26 (1), pp.114-122.e8. ⟨10.1016/j.chom.2019.06.003⟩
Cell Host Microbe

International audience; Quorum sensing molecules (QSMs) are secreted by bacteria to signal population density. Upon reaching a critical concentration, QSMs induce transcriptional alterations in bacteria that enable virulence factor expression and bio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26179527b1239b175e4e8f585a2faa52
https://doi.org/10.1016/j.chom.2019.06.003

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IgE antibodies, FcεRIα, and IgE-mediated local anaphylaxis can limit snake venom toxicity

Autor: Starkl, Philipp, Marichal, Thomas, Gaudenzio, Nicolas, Reber, Laurent Lionel, Sibilano, Riccardo, Tsai, Mindy, Galli, Stephen Joseph, Reber, Laurent, Galli, Stephen

Publikováno v: Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology, Elsevier, 2016, 137 (1), pp.246-257.e11. ⟨10.1016/j.jaci.2015.08.005⟩

Background Type 2 cytokine–related immune responses associated with development of antigen-specific IgE antibodies can contribute to pathology in patients with allergic diseases and to fatal anaphylaxis. However, recent findings in mice indicate th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40e043f2853da5ea6b8faba29a47c1f2
https://hal-univ-tlse3.archives-ouvertes.fr/hal-03431236

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