Calcium levels in the Golgi complex regulate clustering and apical sorting of GPI-APs in polarized epithelial cells

Autor: Julia von Blume, Maria Nitti, Stéphanie Lebreton, Dandan Liu, Chiara Zurzolo, Simona Paladino, Paolo Pinton

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2021, 118 (33), pp.e2014709118. ⟨10.1073/pnas.2014709118⟩
Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (33), pp.e2014709118. ⟨10.1073/pnas.2014709118⟩
Proc Natl Acad Sci U S A

International audience; Glycosylphosphatidylinositol-anchored proteins (GPI-APs) are lipid-associated luminal secretory cargoes selectively sorted to the apical surface of the epithelia where they reside and play diverse vital functions. Cholesterol-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da1cfa4878e77e0b1d36f0524f7f4ca2
https://hal-pasteur.archives-ouvertes.fr/pasteur-03517396

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes

Autor: Emmanuel Lemichez, Brenda A. Schulman, Zhenyue Hao, Sachdev S. Sidhu, Nan Li, Ryan Murchie, Wei Zhang, Maria A. Sartori, Kuen-Phon Wu, Jason Moffat, John R. Walker, Avinash Persaud, Yi Sheng, Alban Ordureau, Jicheng Hu, Chong Jiang, Manjeet Mukherjee, Kevin R. Brown, Yufeng Tong, Yanjun Li, Junjie Chen, Anne Doye, Peter Y. Mercredi, Daniela Rotin, Hari B. Kamadurai, J. Wade Harper

Publikováno v: Molecular Cell
Molecular Cell, Elsevier, 2016, 62 (1), pp.121-136. ⟨10.1016/j.molcel.2016.02.005⟩

Comment in : A Billion Ubiquitin Variants to Probe and Modulate the UPS. [Mol Cell. 2016]; International audience; HECT-family E3 ligases ubiquitinate protein substrates to control virtually every eukaryotic process and are misregulated in numerous d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c0423280b3710b384d45c649c83c073
https://doi.org/10.1016/j.molcel.2016.02.005

Orthologous Mammalian APOBEC3A Cytidine Deaminases Hypermutate Nuclear DNA

Autor: Simon Wain-Hobson, Jean-Pierre Vartanian, Vincent Caval, Rodolphe Suspène

Publikováno v: Molecular Biology and Evolution
Molecular Biology and Evolution, 2014, 31 (2), pp.330-340. ⟨10.1093/molbev/mst195⟩

International audience; The human APOBEC3 gene cluster locus encodes polynucleotide cytidine deaminases. Although many act as viral restriction factors through mutation of single-stranded DNA, recent reports have shown that human APOBEC3A was capable

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e47840f223a21ab569487e3e51ecd161
https://doi.org/10.1093/molbev/mst195

A Renal Olfactory Receptor Aids in Kidney Glucose Handling

Autor: Blythe D. Shepard, Lydie Cheval, Zita Peterlin, Alain Doucet, Jennifer L. Pluznick, Stuart Firestein, Hermann Koepsell

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2016, 6 (1), pp.35215. ⟨10.1038/srep35215⟩
Scientific Reports, Nature Publishing Group, 2016, 6, pp.35215 ⟨10.1038/srep35215⟩
Scientific Reports, 2016, 6, pp.35215 ⟨10.1038/srep35215⟩
Scientific Reports, Nature Publishing Group, 2016, 6, pp.35215 〈10.1038/srep35215〉
Scientific Reports, 2016, 6 (1), pp.35215. ⟨10.1038/srep35215⟩

International audience; Olfactory receptors (ORs) are G protein-coupled receptors which serve important sensory functions beyond their role as odorant detectors in the olfactory epithelium. Here we describe a novel role for one of these ORs, Olfr1393

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1161b3539ba6225aee404c3ac93216b
https://hal.archives-ouvertes.fr/hal-03160866

Investigation of ifosfamide nephrotoxicity induced in a liver-kidney co-culture biochip

Autor: Laurent Grsicom, Christiane Guillouzo, Anne Corlu, Geoffrey Madalinski, Florence Razan, Céline Brochot, Eric Leclerc, Leila Choucha-Snouber, Cécile Legallais, Caroline Aninat, Paul Emile Poleni

Publikováno v: Biotechnology and Bioengineering
Biotechnology and Bioengineering, Wiley, 2013, 110 (2), pp.597-608. ⟨10.1002/bit.24707⟩
Biotechnology and Bioengineering, 2013, 110 (2), pp.597-608. ⟨10.1002/bit.24707⟩

International audience; In this article, we present a liver-kidney co-culture model in a micro fluidic biochip. The liver was modeled using HepG2/C3a and HepaRG cell lines and the kidney using MDCK cell lines. To demonstrate the synergic interaction

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22b9090381337b95369d73bd1a9bf022
https://doi.org/10.1002/bit.24707