Instability of the NS1 Glycoprotein from La Reunion 2018 Dengue 2 Virus (Cosmopolitan-1 Genotype) in Huh7 Cells Is Due to Lysine Residues on Positions 272 and 324

Autor: Philippe Desprès, Olivier Diaz, Pierre-Olivier Vidalain, Vincent Lotteau, Eva Ogire, Marjolaine Roche

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, 2021, 22 (4), pp.1951. ⟨10.3390/ijms22041951⟩
International Journal of Molecular Sciences, Vol 22, Iss 1951, p 1951 (2021)
International Journal of Molecular Sciences, MDPI, 2021, 22 (4), pp.1951. ⟨10.3390/ijms22041951⟩
Volume 22
Issue 4

La Reunion island in the South West Indian Ocean is now endemic for dengue following the introduction of dengue virus serotype 2 (DENV-2) cosmopolitan-I genotype in 2017. DENV-2 infection causes a wide spectrum of clinical manifestations ranging from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ace2478b9e0813fd654ada099d78659
https://pubmed.ncbi.nlm.nih.gov/33669407

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

Autor: Baragaña, Beatriz, Forte, Barbara, Choi, Ryan, Nakazawa Hewitt, Stephen, Bueren-Calabuig, Juan A., Pisco, João Pedro, Peet, Caroline, Dranow, David M., Robinson, David A., Jansen, Chimed, Norcross, Neil R., Vinayak, Sumiti, Anderson, Mark, Brooks, Carrie F., Cooper, Caitlin A., Damerow, Sebastian, Delves, Michael, Dowers, Karen, Duffy, James, Edwards, Thomas E., Hallyburton, Irene, Horst, Benjamin G., Hulverson, Matthew A., Ferguson, Liam, Jiménez-Díaz, María Belén, Jumani, Rajiv S., Lorimer, Donald D., Love, Melissa S., Maher, Steven, Matthews, Holly, McNamara, Case W., Miller, Peter, O’Neill, Sandra, Ojo, Kayode K., Osuna-Cabello, Maria, Pinto, Erika, Post, John, Riley, Jennifer, Rottmann, Matthias, Sanz, Laura M., Scullion, Paul, Sharma, Arvind, Shepherd, Sharon M., Shishikura, Yoko, Simeons, Frederick R. C., Stebbins, Erin E., Stojanovski, Laste, Straschil, Ursula, Tamaki, Fabio K., Tamjar, Jevgenia, Torrie, Leah S., Vantaux, Amélie, Witkowski, Benoît, Wittlin, Sergio, Yogavel, Manickam, Zuccotto, Fabio, Angulo-Barturen, Iñigo, Sinden, Robert, Baum, Jake, Gamo, Francisco-Javier, Mäser, Pascal, Kyle, Dennis E., Winzeler, Elizabeth A., Myler, Peter J., Wyatt, Paul G., Floyd, David, Matthews, David, Sharma, Amit, Striepen, Boris, Huston, Christopher D., Gray, David W., Fairlamb, Alan H., Pisliakov, Andrei V., Walpole, Chris, Read, Kevin D., Van Voorhis, Wesley C., Gilbert, Ian H.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, 116 (14), pp.7015-7020. ⟨10.1073/pnas.1814685116⟩
'Proceedings of the National Academy of Sciences of the USA ', vol: 116, pages: 7015-7020 (2019)

Significance Malaria and cryptosporidiosis are major burdens to both global health and economic development in many countries. Malaria caused >400,000 deaths in 2017, and cryptosporidiosis is estimated to cause >200,000 deaths a year. The spread of d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e2d6abb2cc058da4620b9d3812d77ae7

Understanding the Mechanism of the Broad-Spectrum Antiviral Activity of Favipiravir (T-705): Key Role of the F1 Motif of the Viral Polymerase

Autor: Mathy Froeyen, Leen Delang, Stéphanie Beaucourt, Bruno Canard, Ana Theresa Silveira de Morais, Isabelle Imbert, Johan Neyts, Marco Vignuzzi, Hervé Blanc, Pieter Leyssen, Rana Abdelnabi

Publikováno v: Journal of Virology
Journal of Virology, 2017, 91 (12), pp.e00487-17. ⟨10.1128/JVI.00487-17⟩
Journal of Virology, American Society for Microbiology, 2017, 91 (12), pp.e00487-17. ⟨10.1128/JVI.00487-17⟩

Favipiravir (T-705) is a broad-spectrum antiviral agent that has been approved in Japan for the treatment of influenza virus infections. T-705 also inhibits the replication of various RNA viruses, including chikungunya virus (CHIKV). We demonstrated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95ec8ca79e6936169943b98e6fae68ff
https://hal-pasteur.archives-ouvertes.fr/pasteur-02545928

Identification and Characterization of a Novel Human Methyltransferase Modulating Hsp70 Protein Function through Lysine Methylation

Autor: Ronald Melki, Stefan Kernstock, Wolfgang Egge-Jacobsen, Anders Moen, Luc Bousset, Magnus E. Jakobsson, Pål Ø. Falnes

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2013, 288 (39), pp.27752-63. ⟨10.1074/jbc.M113.483248⟩

International audience; Hsp70 proteins constitute an evolutionarily conserved protein family of ATP-dependent molecular chaperones involved in a wide range of biological processes. Mammalian Hsp70 proteins are subject to various post-translational mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3a61de44f78cbfe48de470da3f57bad
https://doi.org/10.1074/jbc.m113.483248

Protein SUMOylation Is Required for Regulatory T Cell Expansion and Function

Autor: Chen Dong, Aibo Wang, Xiaopeng Ma, Wei Jin, Huawei Xin, Maud D. Demarque, Xiao Ding, Anne Dejean

Publikováno v: Cell Reports
Cell Reports, Elsevier Inc, 2016, 16 (4), pp.1055-1066. ⟨10.1016/j.celrep.2016.06.056⟩
Cell Reports, 2016, 16 (4), pp.1055-1066. ⟨10.1016/j.celrep.2016.06.056⟩
Cell Reports, Vol 16, Iss 4, Pp 1055-1066 (2016)

International audience; Foxp3-expressing regulatory T (Treg) cells are essential for immune tolerance; however, the molecular mechanisms underlying Treg cell expansion and function are still not well understood. SUMOylation is a protein post-translat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b20d51d1f043df5f991f4ad2d3ade1cd
https://hal-pasteur.archives-ouvertes.fr/pasteur-03234943