Detection of anti‐domain I antibodies by chemiluminescence enables the identification of high‐risk antiphospholipid syndrome patients: A multicenter multiplatform study

Autor: Dongmei Yin, Katrien Devreese, Walid Chayoua, Gary W. Moore, Bas de Laat, Jacek Musiał, Hilde Kelchtermans, Jean-Christophe Gris, Stéphane Zuily, Philip G. de Groot

Publikováno v: Journal of Thrombosis and Haemostasis
Journal of Thrombosis and Haemostasis, Wiley, 2020, 18 (2), pp.463-478. ⟨10.1111/jth.14682⟩
Journal of Thrombosis and Haemostasis, 18(2), 463-478. Wiley

Background Classification of the antiphospholipid syndrome (APS) relies predominantly on detecting antiphospholipid antibodies (aPLs). Antibodies against a domain I (DI) epitope of anti-beta 2glycoprotein I (beta 2GPI) proved to be pathogenic, but ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::783dd1459c3a393252cf2b1ce7e7db2d
https://doi.org/10.1111/jth.14682

Peptide aptamers for small molecule drug discovery

Autor: Carine, Bardou, Christophe, Borie, Marc, Bickle, Brian B, Rudkin, Pierre, Colas

Publikováno v: Methods in Molecular Biology (Clifton then Totova)
Methods in Molecular Biology (Clifton then Totova), Humana Press (Springer Imprint), 2009, 535, pp.373-88. 〈10.1007/978-1-59745-557-2_21〉
Methods in Molecular Biology
Methods in Molecular Biology, 2009, 535, pp.373-88. ⟨10.1007/978-1-59745-557-2_21⟩
Methods in Molecular Biology, Humana Press/Springer Imprint, 2009, 535, pp.373-88. ⟨10.1007/978-1-59745-557-2_21⟩

International audience; Peptide aptamers have primarily been used as research tools to manipulate protein function and study regulatory networks. However, they also find multiple applications in therapeutic research, from target identification and va

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::acb29f59dea506c456626c378240a439
https://hal.archives-ouvertes.fr/hal-00416047

New in-capillary electrophoretic kinase assays to evaluate inhibitors of the PI3k/Akt/mTOR signaling pathway

Autor: Pierre Verrelle, Philippe Morin, Marie-Ludivine de-Tauzia, Emmanuel Chautard, Sylvain Routier, H. Bénédetti, Frédéric Buron, Hala Nehmé, Thibault Saurat, Reine Nehmé, Pierre Lafite

Publikováno v: Analytical and Bioanalytical Chemistry
Analytical and Bioanalytical Chemistry, Springer Verlag, 2014, 406 (15), pp.3743-3754. ⟨10.1007/s00216-014-7790-z⟩
Analytical and Bioanalytical Chemistry, 2014, 406 (15), pp.3743-3754. ⟨10.1007/s00216-014-7790-z⟩

International audience; Human kinases are one of the most promising targets for cancer therapy. Methods able to measure the effects of drugs on these cell agents remain crucial for biologists and medicinal chemists. The current work therefore sought

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::399176b61822098196edec138ca08644
https://hal.archives-ouvertes.fr/hal-01180770/file/Nehme2014.pdf

Pyridine-based lanthanide complexes combining MRI and NIR luminescence activities

Autor: Célia S. Bonnet, Jian Zhang, Chantal Pichon, Stéphane Petoud, Frédéric Buron, Sandrine Villette, Franck Suzenet, Bohuslav Drahoš, Lothar Helm, Chad M. Shade, Laurent Pellegatti, Éva Tóth, Fabien Caillé

Publikováno v: Chemistry-A European Journal
Chemistry-A European Journal, Wiley-VCH Verlag, 2012, 18 (5), pp.1419-31. ⟨10.1002/chem.201102310⟩

International audience; A series of novel triazole derivative pyridine-based polyamino-polycarboxylate ligands has been synthesized for lanthanide complexation. This versatile platform of chelating agents combines advantageous properties for both mag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3738c604fa487979faac7e5fea061b47
https://hal.archives-ouvertes.fr/hal-00720541

Study of the role of novel RF-amide neuropeptides in affecting growth hormone secretion in a representative non-human primate (Macaca mulatta)

Autor: Jérôme Leprince, Rizwan Hashim, Manuel Tena-Sempere, Muhammad Amin Wiqar, Hubert Vaudry, Fatima Qaiser, Fazal Wahab, Muhammad Shahab

Publikováno v: Endocrine
Endocrine, Springer, 2012, 42 (3), pp.658-663. ⟨10.1007/s12020-012-9672-5⟩

International audience; RF amide peptide family with distinctive terminal -Arg-Phe-NH(2) signature is evolutionarily conserved from invertebrates to mammals. These neuropeptides have been shown to affect diverse functions in invertebrates and vertebr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::802eeef57b681249ad8de91f60eeeaa4
https://pubmed.ncbi.nlm.nih.gov/22527890