A comprehensive study of metabolite genetics reveals strong pleiotropy and heterogeneity across time and context

Autor: Noah Zaitlen, Päivi Pajukanta, Hanna Julienne, Joel Mefford, Hugues Aschard, Arthur Ko, Mika Ala-Korpela, Amaury Vaysse, Apolline Gallois, Markku Laakso

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature communications, vol 10, iss 1
Nature Communications
Nature Communications, 2019, 10 (1), pp.4788. ⟨10.1038/s41467-019-12703-7⟩
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.4788. ⟨10.1038/s41467-019-12703-7⟩
Nature Communications, Nature Publishing Group, 2019, 10 (1), ⟨10.1038/s41467-019-12703-7⟩
Gallois, A, Mefford, J, Ko, A, Vaysse, A, Julienne, H, Ala-Korpela, M, Laakso, M, Zaitlen, N, Pajukanta, P & Aschard, H 2019, ' A comprehensive study of metabolite genetics reveals strong pleiotropy and heterogeneity across time and context ', Nature Communications, vol. 10, 4788 . https://doi.org/10.1038/s41467-019-12703-7

Genetic studies of metabolites have identified thousands of variants, many of which are associated with downstream metabolic and obesogenic disorders. However, these studies have relied on univariate analyses, reducing power and limiting context-spec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d41bd8ebe465f823f78ad49095d4282c
https://doaj.org/article/18f5d61c166a4f04bdb8979fa46f9cb9

Maintenance of Macrophage Redox Status by ChREBP Limits Inflammation and Apoptosis and Protects against Advanced Atherosclerotic Lesion Formation

Autor: Sarrazy, Vincent, Sore, Sophie, Viaud, Manon, Rignol, Guylène, Westerterp, Marit, Ceppo, Franck, Tanti, Jean-François, Guinamard, Rodolphe r., Gautier, Emmanuel L., Yvan-Charvet, Laurent

Publikováno v: Cell Reports
Cell Reports, 2015, 13 (1), pp.132-144. ⟨10.1016/j.celrep.2015.08.068⟩
Cell Reports, Elsevier Inc, 2015, 13 (1), pp.132-144. ⟨10.1016/j.celrep.2015.08.068⟩
Cell reports, 13(1), 132-144. CELL PRESS
Cell Reports, Vol 13, Iss 1, Pp 132-144 (2015)

International audience; Enhanced glucose utilization can be visualized in atherosclerotic lesions and may reflect a high glycolytic rate in lesional macrophages, but its causative role in plaque progression remains unclear. We observe that the activi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::035a43cfb378cad593dae2af5c8ac7d3
https://hal.science/hal-03798234

Mature Dendritic Cell Generation Promoted by Lysophosphatidylcholine

Autor: Patrice Andre, Thierry Delair, Sophie Agaugué, Vincent Lotteau, Laure Perrin-Cocon, Frédéric Coutant

Publikováno v: Journal of Immunology
Journal of Immunology, 2002, 169 (4), pp.1688-95

During the acute phase response, the interplay between high density lipoproteins and low density lipoproteins (LDL) favors transient generation of oxidized LDL with proinflammatory activities. We hypothesized that oxidative modification of LDL is an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afedd39b8377d7a3b0d5d684eb7db320
https://doi.org/10.4049/jimmunol.169.4.1688

Induction of dendritic cell-mediated T-cell activation by modified but not native low-density lipoprotein in humans and inhibition by annexin a5: involvement of heat shock proteins

Autor: Claes Bergmark, Johan Frostegård, Anquan Liu, Ewa Ninio, Roland Fiskesund, Julia Yue Ming, Sonia-Athina Karabina, Anna G. Frostegård

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology
Arteriosclerosis, Thrombosis, and Vascular Biology, 2015, 35 (1), pp.197-205. ⟨10.1161/ATVBAHA.114.304342⟩

Objective— Atherosclerosis is an inflammatory disease, where activated immunocompetent cells, including dendritic cells (DCs) and T cells are abundant in plaques. Low-density lipoprotein modified either by oxidation (oxLDL) or by human group X-secr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b37b603bf083de9b6b4de1f3df659903
https://pubmed.ncbi.nlm.nih.gov/25395618

Metabolic syndrome features small, apolipoprotein A-I-poor, triglyceride-rich HDL3 particles with defective anti-apoptotic activity

Autor: Juliana A. de Souza, Carlos V. Serrano, Anatol Kontush, M. John Chapman, Anne Nègre-Salvayre, S. Chantepie, Cécile Vindis, Robert Salvayre, Boris Hansel, P. Thérond, Eric Bruckert

Publikováno v: Atherosclerosis
Atherosclerosis, 2008, 197 (1), pp.84-94. ⟨10.1016/j.atherosclerosis.2007.08.009⟩
Atherosclerosis, Elsevier, 2008, 197 (1), pp.84-94. ⟨10.1016/j.atherosclerosis.2007.08.009⟩
Atherosclerosis, Elsevier, 2008, 197 (1), pp.84-94. 〈10.1016/j.atherosclerosis.2007.08.009〉

International audience; The metabolic syndrome (MetS) phenotype is typically characterized by visceral obesity, insulin resistance, atherogenic dyslipidemia involving hypertriglyceridemia and subnormal levels of high density lipoprotein-cholesterol (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07e30584b450b5471719a79073ef1314
https://www.hal.inserm.fr/inserm-00408921