Allosteric modulation of ghrelin receptor signaling by lipids

Autor: Louet, Maxime, Casiraghi, Marina, Damian, Marjorie, Costa, Mauricio GS, Renault, Pedro, Gomes, Antoniel AS, Batista, Paulo, M'Kadmi, Céline, Mary, Sophie, Cantel, Sonia, Denoyelle, Severine, Ben Haj Salah, Khoubaib, Perahia, David, Bisch, Paulo, Fehrentz, Jean-Alain, Catoire, Laurent, Floquet, Nicolas, Banères, Jean-Louis, Mustafá, Emilio, Cordisco González, Santiago, Wagner, Renaud, Schiöth, Helgi, Perelló, Mario, Raingo, Jesica, Gomes, Antoniel Augusto Severo, M’Kadmi, Céline

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), ⟨10.1038/s41467-021-23756-y⟩
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.3938. ⟨10.1038/s41467-021-23756-y⟩
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

The membrane is an integral component of the G protein-coupled receptor signaling machinery. Here we demonstrate that lipids regulate the signaling efficacy and selectivity of the ghrelin receptor GHSR through specific interactions and bulk effects.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6753e5a97fd1534f0686c5135c0c76a6
https://hal.archives-ouvertes.fr/hal-03357159

Thyroid Hormone Receptor α Regulates Autophagy, Mitochondrial Biogenesis, and Fatty Acid Use in Skeletal Muscle

Autor: Xuguang Zhu, Rohit A. Sinha, Jia Pei Ho, Paul M. Yen, Cho Rong Han, Karine Gauthier, Sheue-yann Cheng, Andrea Lim, Jin Zhou

Publikováno v: Endocrinology
Endocrinology, 2021, 162 (9), ⟨10.1210/endocr/bqab112⟩
Endocrinology, Endocrine Society, 2021, 162 (9), ⟨10.1210/endocr/bqab112⟩

Skeletal muscle (SM) weakness occurs in hypothyroidism and resistance to thyroid hormone α (RTHα) syndrome. However, the cell signaling and molecular mechanism(s) underlying muscle weakness under these conditions is not well understood. We thus exa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e473ccb3ae8d0e9b9d86e615b07c0215
https://hal.science/hal-03403597

Lysosomal Acid Lipase Drives Adipocyte Cholesterol Homeostasis and Modulates Lipid Storage in Obesity, Independent of Autophagy

Autor: Emmanuel L. Gautier, Amélie Lacombe, Dominique Farabos, Christine Rouault, Camille Gamblin, Antonin Lamaziere, Laurent Yvan-Charvet, Francina Langa-Vives, Karine Clément, Isabelle Dugail

Publikováno v: Diabetes
Diabetes, 2020, 70 (1), pp.76-90. ⟨10.2337/db20-0578⟩
Diabetes, 2021, 70 (1), pp.76-90. ⟨10.2337/db20-0578⟩
Diabetes, American Diabetes Association, 2020, 70 (1), pp.76-90. ⟨10.2337/db20-0578⟩

International audience; Besides cytoplasmic lipase-dependent adipocyte fat mobilization, the metabolic role of lysosomal acid lipase (LAL), highly expressed in adipocytes, is unclear. We show that the isolated adipocyte fraction, but not the total un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb06c80cfc4320a0df5576e5f9b288d1
https://hal.sorbonne-universite.fr/hal-03157930/document

Acetyl-CoA Carboxylase Inhibitor CP640.186 Increases Tubulin Acetylation and Impairs Thrombin-Induced Platelet Aggregation

Autor: Marie Octave, Laurence Pirotton, Audrey Ginion, Valentine Robaux, Sophie Lepropre, Jérôme Ambroise, Caroline Bouzin, Bruno Guigas, Martin Giera, Marc Foretz, Luc Bertrand, Christophe Beauloye, Sandrine Horman

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, 2021, 22 (23), pp.13129. ⟨10.3390/ijms222313129⟩
International Journal of Molecular Sciences, 22(23). MDPI
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 13129
International Journal of Molecular Sciences, Vol 22, Iss 13129, p 13129 (2021)
International journal of molecular sciences, Vol. 22, no. 23, p. 13129 [1-17] (2021)

International audience; Acetyl-CoA carboxylase (ACC) is the first enzyme regulating de novo lipid synthesis via the carboxylation of acetyl-CoA into malonyl-CoA. The inhibition of its activity decreases lipogenesis and, in parallel, increases the ace

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::441d460f33aa769cd4b3b498816c1247
https://doi.org/10.3390/ijms222313129

Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα

Autor: Tarja Schröder, Matteo Pedrelli, Luc Van Gaal, Anthony N. Hollenberg, Arturo Mendoza, Philippe Lefebvre, Ning Liang, Saioa Goñi, Zhiqiang Huang, Bart Staels, Raoul Kuiper, Paolo Parini, Serena Barilla, Lise Lotte Vedin, Eckardt Treuter, Nicolas Venteclef, Sven Francque, Tomas Jakobsson, Anastasius Damdimopoulos, Marco Giudici, Rongrong Fan, Fawaz Alzaid, Osman Ahmed

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.1684. ⟨10.1038/s41467-019-09524-z⟩
Nature Communications, 2019, 10 (1), pp.1684. ⟨10.1038/s41467-019-09524-z⟩
Nature communications
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

Obesity triggers the development of non-alcoholic fatty liver disease (NAFLD), which involves alterations of regulatory transcription networks and epigenomes in hepatocytes. Here we demonstrate that G protein pathway suppressor 2 (GPS2), a subunit of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bda4f2121737c067e7c9c5471aeeb6a3
https://www.hal.inserm.fr/inserm-02154801/document