Glycomimetic ligands block the interaction of SARS-CoV-2 spike protein with C-type lectin co-receptors

Autor: Sara Pollastri, Clara Delaunay, Michel Thépaut, Franck Fieschi, Anna Bernardi

Publikováno v: Chemical Communications
Chemical Communications, 2022, 58 (33), pp.5136-5139. ⟨10.1039/d2cc00121g⟩

International audience; The C-type lectin receptors DC-SIGN and L-SIGN bind to glycans on the SARS-CoV-2 spike glycoprotein and promote trans-infection of ACE2-expressing cells. We tested C2 triazole-modified mono- and pseudo-di-mannosides as inhibit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1de62048e05c7d191ba89a2b0e775c7a
https://doi.org/10.1039/d2cc00121g

Targeting androgen signaling in ILC2s protects from IL-33–driven lung inflammation, independently of KLRG1

Autor: Blanquart, Eve, Mandonnet, Audrey, Mars, Marion, Cenac, Claire, Anesi, Nina, Mercier, Pascale, Audouard, Christophe, Roga, Stephane, Serrano de Almeida, Gilberto, Bevan, Charlotte, Girard, Jean-Philippe, Pelletier, Lucette, Laffont, Sophie, Guéry, Jean-Charles

Publikováno v: Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology, 2022, 149 (1), pp.237-251.e12. ⟨10.1016/j.jaci.2021.04.029⟩
Journal of Allergy and Clinical Immunology, Elsevier, 2021, ⟨10.1016/j.jaci.2021.04.029⟩

International audience; Background: Allergic asthma is more severe and frequent in women than in men. In male mice, androgens negatively control group 2 innate lymphoid cell (ILC2) development and function by yet unknown mechanisms.Objectives: We sou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b00285143bc2806041962f70f839ba74
https://hal.science/hal-03411390/file/1-s2.0-S0091674921007259-main-5.pdf

New lipophilic glycomimetic DC-SIGN ligands: Stereoselective synthesis and SPR-based binding inhibition assays

Autor: Mauro Pineschi, Paolo Crotti, Dalila Iacopini, Franck Fieschi, Vittorio Bordoni, Silvia Achilli, Valeria Di Bussolo, Michel Thépaut, Sebastiano Di Pietro

Publikováno v: Bioorganic Chemistry
Bioorganic Chemistry, Elsevier, 2021, 107, pp.104566. ⟨10.1016/j.bioorg.2020.104566⟩
Bioorganic Chemistry, 2021, 107, pp.104566. ⟨10.1016/j.bioorg.2020.104566⟩

International audience; The design and synthesis of efficient ligands for DC-SIGN is a topic of high interest, because this C-type lectin has been implicated in the early stages of many infection processes. DC-SIGN membrane-protein presents four carb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c3e66ea02fbd1a247af2ca81dc41cfd
https://doi.org/10.1016/j.bioorg.2020.104566

Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus

Autor: Mark H. T. Stappers, Matteo Zanda, Axel A. Brakhage, Mihai G. Netea, Ivy M. Dambuza, António Campos, Delyth M. Reid, Ten Feizi, Carol Wallace, Betty Hebecker, Jean-Paul Latgé, João F. Lacerda, Neil A. R. Gow, Frank L. van de Veerdonk, Maria da Glória Teixeira de Sousa, Patawee Asamaphan, Kyung J. Kwon-Chung, Monica Piras, Martin Jaeger, Cristina Cunha, Vishukumar Aimanianda, Janet A. Willment, Alexandra E. Clark, Raif Yuecel, Chiara Zanato, Isabel Valsecchi, Yan Liu, Agostinho Carvalho, Bernhard Kerscher, Sarah E. Hardison, Anthony Plato, Stefan Bidula, Gordon D. Brown

Publikováno v: Nature, 555, 7696, pp. 382-386
Nature
Nature, Nature Publishing Group, 2018, 555 (7696), pp.382-386. ⟨10.1038/nature25974⟩
Nature, 555, 382-386
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Nature, 2018, 555 (7696), pp.382-386. ⟨10.1038/nature25974⟩

© 2018 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
Resistance to infection is critically dependent on the ability of pattern recognition receptors to recognize microbial invasion and induce protective immune resp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff61ca704d5de2aa7a584d3e436cd0b3
https://hdl.handle.net/2066/190136

Differential Use of the C-Type Lectins L-SIGN and DC-SIGN for Phlebovirus Endocytosis

Autor: Léger, Psylvia, Tetard, Marilou, Youness, Berthe, Cordes, Nicole, Rouxel, Ronan N, Flamand, Marie, Lozach, Pierre-Yves

Publikováno v: Traffic
Traffic, Wiley, 2016, 17 (6), pp.639-56. ⟨10.1111/tra.12393 ⟩
Traffic, Wiley, 2016, 17 (6), pp.639-56. ⟨10.1111/tra.12393⟩
Traffic, 2016, 17 (6), pp.639-56. ⟨10.1111/tra.12393⟩

International audience; Bunyaviruses represent a growing threat to humans and livestock globally. The receptors, cellular factors and endocytic pathways used by these emerging pathogens to infect cells remain largely unidentified and poorly character

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::855ecf8d3ad357eb2892ccef090f8a46
https://hal-riip.archives-ouvertes.fr/pasteur-01351418/document