Combined Structural Analysis and Molecular Dynamics Reveal Penicillin-Binding Protein Inhibition Mode with β-Lactones

Autor: Parker L. Flanders, Carlos Contreras-Martel, Nathaniel W. Brown, Joshua D. Shirley, Alexandre Martins, Kelsie N. Nauta, Andréa Dessen, Erin E. Carlson, Elizabeth A. Ambrose

Publikováno v: ACS Chemical Biology
ACS Chemical Biology, 2022, 17 (11), pp.3110-3120. ⟨10.1021/acschembio.2c00503⟩
ACS Chem Biol

International audience; β-Lactam antibiotics comprise one of the most widely used therapeutic classes to combat bacterial infections. This general scaffold has long been known to inhibit bacterial cell wall biosynthesis by inactivating penicillin-bi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0783d061071e82755c439d798d76a74
https://hal.science/hal-03969300

Interaction of an odorant lactone with model phospholipid bilayers and its strong fluidizing action in yeast membrane

Autor: Yves Waché, Mario Aguedo, Laurent Beney, Jean-Marc Belin

Publikováno v: International Journal of Food Microbiology
International Journal of Food Microbiology, Elsevier, 2003, 80 (3), pp.211-5. ⟨10.1016/S0168-1605(02)00150-2⟩
International Journal of Food Microbiology, Elsevier, 2003, 80 (3), pp.211-5

International audience; Some odorant lactones are naturally present in fruits or in fermented products; they can also be used as food additives and can be produced by microorganisms at the industrial scale by biotechnological processes. Gamma-decalac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c18ef873a2c5482f1b8a9233bbab80d
https://doi.org/10.1016/s0168-1605(02)00150-2

A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms

Autor: Benoit Witkowski, Hans-Peter Fuehrer, Garib Das Thakur, Céline Barnadas, Djibrine Djalle, Michael Ramharter, Mindy Leelawong, Wasif Ali-Khan, Harald Noedl, Bouasy Hongvanthong, Mohammad Shafiul-Alam, Hypolite Muhindo-Mavoko, Abdillahi Mohamed Hassan, Judith Straimer, Nimol Khim, Kigbafori D. Silué, Kaknika Loch, Barbara H. Stokes, Maria Dorina Bustos, Laura Berne, Dylan R. Pillai, Ayola A. Adegnika, Lin Hua Tang, Rotha Eam, Saorin Kim, Alioune Dieye, Mei Li, Carole E. Eboumbou-Moukoko, Lydie Canier, Marian Warsame, Didier Menard, David A. Fidock, Yap Boum, Lyndes Wini, Abdiqani Sheikh-Omar, Patrick Tshibangu-Wa-Tshibangu, Maman Laminou Ibrahim, Mohammad Jahirul-Karim, Malen Ken, Monique A. Dorkenoo, Sócrates Herrera, Odile Mercereau-Puijalon, Lise Musset, Valentine Duru, Eric Legrand, Maniphone Khanthavong, Pascal Ringwald, Bruno Pradines, Sandrine Houzé, Rachida Tahar, Olukemi K. Amodu, Johann Beghain, Sandie Menard, Liwang Cui, Colin J. Sutherland, Jun Hu Chen, Kesara Na-Bangchang, Khin Lin, Michael Nambozi, Rithea Leang, Jean Christophe Barale, Milijaona Randrianarivelojosia, Marcus V. G. Lacerda, Sophy Chy, Frédéric Ariey, Jean-Bosco Ouédraogo, Isabelle Morlais, Maria de Fátima Ferreira-da-Cruz, Lubin Jiang, Christophe Rogier, Jun Cao, Peter G. Kremsner, Bui Quang-Phuc, Inès Vigan-Womas, Din Syafruddin, Jetsumon Sattabongkot, Shigeyuki Kano, Abebe A. Fola, Louis Collet, Karamoko Niaré, Thierry Fandeur, Sedigheh Zakeri, Sodiomon B. Sirima, Antoine Berry, Jean Baptiste Mazarati, Fe Espino, Ghulam Rahim-Awab, Chanra Khean, Offianan Andre Toure

Publikováno v: New England Journal of Medicine
New England Journal of Medicine, 2016, 374 (25), pp.2453-64. ⟨10.1056/NEJMoa1513137⟩
New England Journal of Medicine, Massachusetts Medical Society, 2016, 374 (25), pp.2453-64. ⟨10.1056/NEJMoa1513137⟩
The New England journal of medicine

Comment inK13-Propeller Mutations and Malaria Resistance, http://www.nejm.org/doi/full/10.1056/NEJMe1604520; International audience; BACKGROUND:Recent gains in reducing the global burden of malaria are threatened by the emergence of Plasmodium falcip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1187e334d9bb61f9141080c7a998d9c2
https://hal-pasteur.archives-ouvertes.fr/pasteur-01336483

Detection of Gymnodimine-A and 13-Desmethyl C Spirolide Phycotoxins by Fluorescence Polarization

Autor: Rómulo Aráoz, Eva S. Fonfría, Jordi Molgó, Natalia Vilariño, Luis M. Botana

Publikováno v: Analytical Chemistry
Analytical Chemistry, American Chemical Society, 2009, 81 (7), pp.2708-14. ⟨10.1021/ac900144r⟩

International audience; The gymnodimines and spirolides are phycotoxins classified into a heterogeneous group of marine biocompounds called cyclic imines. Although there is no clear evidence of their toxicity to humans, gymnodimines and spirolides ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7d5cc2914d51af1f1c97eaa492aa81b

Decalactone production by Yarrowia lipolytica under increased O2 transfer rates

Autor: Nelma Gomes, Isabel Belo, José A. Teixeira, Mario Aguedo, Manuel Mota, Yves Waché, Erandi Escamilla Garcia

Publikováno v: Biotechnology Letters
Biotechnology Letters, Springer Verlag, 2005, 27 (20), pp.1617-21. ⟨10.1007/s10529-005-2517-z⟩
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Biotechnology Letters, Springer Verlag, 2005, 27 (20), pp.1617-21. 〈10.1007/s10529-005-2517-z〉

Yarrowia lipolytica converts methyl ricinoleate to γ-decalactone, a high-value fruity aroma compound. The highest amount of 3-hydroxy-γ-decalactone produced by the yeast (263 mg lˉ¹) occurred by increasing the kLa up to 120 hˉ¹ at atmospheric p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b098c9b52c329c6c9c03957d7be1b15e
https://hal.archives-ouvertes.fr/hal-00368199