Výsledky vyhledávání - "MESH: Ketones"

The α-hydroxyketone LAI-1 regulates motility, Lqs-dependent phosphorylation signalling and gene expression of Legionella pneumophila

Autor: Schell, Ursula, Simon, Sylvia, Sahr, Tobias, Hager, Dominik, Albers, Michael F., Kessler, Aline, Fahrnbauer, Felix, Trauner, Dirk, Hedberg, Christian, Buchrieser, Carmen, Hilbi, Hubert

Publikováno v: Molecular Microbiology
Molecular Microbiology, Wiley, 2016, 99 (4), pp.778-793. ⟨10.1111/mmi.13265⟩
Molecular Microbiology, 2016, 99 (4), pp.778-793. ⟨10.1111/mmi.13265⟩

International audience; The causative agent of Legionnaires' disease, Legionella pneumophila, employs the autoinducer compound LAI-1 (3-hydroxypentadecane-4-one) for cell-cell communication. LAI-1 is produced and detected by the Lqs (Legionella quoru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7385ba9180638110188fe68ab1497ffc
https://hal-pasteur.archives-ouvertes.fr/pasteur-01423073

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The Prins Reaction Using Ketones: Rationalization and Application toward the Synthesis of the Portentol Skeleton

Autor: Pierre van de Weghe, Nicolas Levoin, Maiwenn Jacolot, Mickael Jean

Publikováno v: Organic Letters
Organic Letters, 2012, 14 (1), pp.58-61. ⟨10.1021/ol202829u⟩
Organic Letters, American Chemical Society, 2012, 14 (1), pp.58-61. ⟨10.1021/ol202829u⟩

International audience; We report a TMSI-promoted Prins cyclization reaction with ketones as carbonyl partners to prepare polysubstituted chiral spirotetrahydropyrans. In the presence of racemic 2-methylcyclohexanone a dynamic kinetic resolution occu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fd4689a2d542bbf7652661764550e13
https://doi.org/10.1021/ol202829u

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Targeting of the Brucella suis Virulence Factor Histidinol Dehydrogenase by Histidinol Analogues Results in Inhibition of Intramacrophagic Multiplication of the Pathogen

Autor: Jean-Yves Winum, Jean-Louis Montero, Stephan Köhler, Pascale Joseph, Marie-Rose Abdo, Rose-Anne Boigegrain

Publikováno v: Antimicrobial Agents and Chemotherapy
Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2007, 51 (10), pp.3752-5. ⟨10.1128/AAC.00572-07⟩

Brucella suis histidinol dehydrogenase (HDH) can be efficiently targeted by substrate analogues. The growth of this pathogen in minimal medium was inhibited and the multiplication in human macrophages was totally abolished in the presence of the drug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::003d3e16058205b6d2de840d0c6a2ec6
https://doi.org/10.1128/aac.00572-07

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Coenzyme binding during catalysis is beneficial for the stability of 4-hydroxyacetophenone monooxygenase

Autor: van den Heuvel, R.H.H., Tahallah, N., Kamerbeek, N.M, Fraaije, M.W., Berkel, W.J.H., Janssen, D.B., Heck, A.J.R., van Berkel, WJH

Publikováno v: The Journal of Biological Chemistry, 280(37), 32115-32121. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2005, 280 (37), pp.32115-21. ⟨10.1074/jbc.M503758200⟩

International audience; The NADPH-dependent dimeric flavoenzyme 4-hydroxyacetophenone monooxygenase (HAPMO) catalyzes Baeyer-Villiger oxidations of a wide range of ketones, thereby generating esters or lactones. In the current work, we probed HAPMO-c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::401be22be2b10f37394642f5c04cdbe2
https://research.rug.nl/en/publications/a3b93809-dee3-44c9-800f-b5a147f20653

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Sp1 Is Involved in Akt-mediated Induction of VEGF Expression through an HIF-1–independent Mechanism

Autor: Hui-Kuo G. Shu, Nabendu Pore, Gilles Pagès, Donald M. O'Rourke, Amit Maity, Bin Li, Eric J. Bernhard, Julie Milanini-Mongiat, Shuang Liu, David Stokoe, Daphne A. Haas-Kogan

Publikováno v: Molecular Biology of the Cell
Molecular Biology of the Cell, American Society for Cell Biology, 2004, 15 (11), pp.4841-53. ⟨10.1091/mbc.E04-05-0374⟩

International audience; Increased expression of vascular endothelial growth factor (VEGF) contributes to the growth of many tumors by increasing angiogenesis. Although hypoxia is a potent inducer of VEGF, we previously showed that epidermal growth fa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9824e852e7562b5cef9cb17377794cd5
https://doi.org/10.1091/mbc.e04-05-0374

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Unusual Regioselectivity and Active Site Topology of Human Cytochrome P450 2J2

Autor: Pierre Lafite, Patrick M. Dansette, François André, Darryl C. Zeldin, Daniel Mansuy

Publikováno v: Biochemistry
Biochemistry, American Chemical Society, 2007, pp.10237-10247
Biochemistry, American Chemical Society, 2007, 46 (36), pp.10237-47. ⟨10.1021/bi700876a⟩
Biochemistry, American Chemical Society, 2007, 46 (36), pp.10237-47. 〈10.1021/bi700876a〉
Biochemistry, 2007, pp.10237-10247
Biochemistry, 2007, 46 (36), pp.10237-47. ⟨10.1021/bi700876a⟩

The oxidation of six derivatives of terfenadone by recombinant human CYP2J2 (CYP = cytochrome P450) was studied by high-performance liquid chromatography coupled to mass spectrometry (MS) using tandem MS techniques and by 1H NMR spectroscopy. CYP2J2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62f5295373619791c2e567d42d8697a8
https://hal.archives-ouvertes.fr/hal-00259028

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VOC Contamination in Hospital, from Stationary Sampling of a Large Panel of Compounds, in View of Healthcare Workers and Patients Exposure Assessment

Autor: Sylvie Buffet-Bataillon, Vincent Bessonneau, Adèle Berrubé, Olivier Thomas, Luc Mosqueron, Gaël Mukensturm, Jean-Pierre Gangneux

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2013, 8 (2), pp.e55535. ⟨10.1371/journal.pone.0055535⟩
PLoS ONE, Vol 8, Iss 2, p e55535 (2013)
PLoS ONE, 2013, 8 (2), pp.e55535. ⟨10.1371/journal.pone.0055535⟩

International audience; BACKGROUND: We aimed to assess, for the first time, the nature of the indoor air contamination of hospitals. METHODS AND FINDINGS: More than 40 volatile organic compounds (VOCs) including aliphatic, aromatic and halogenated hy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb78959b6af6a03434a1fa366bce9475
http://europepmc.org/articles/PMC3564763

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Synthesis and analytical investigation of C-terminally modified peptide aldehydes and ketone: application to oxime ligation

Autor: Buré, Corinne, Marceau, Philippe, Meudal, Hervé, Delmas, Agnès F

Publikováno v: Journal of Peptide Science
Journal of Peptide Science, Wiley, 2012, 18 (3), pp.147-54. ⟨10.1002/psc.1429⟩

International audience; C-terminally modified peptides aldehyde (glycinal and alpha-oxo aldehyde peptides) and ketone (pyruvic acid-containing peptide) were synthesised to get new insights into the mechanism of acido-catalysed oxime ligation. Their t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::111f263768a91c913d72208eca13be6f
https://hal.archives-ouvertes.fr/hal-00721799

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Switching reversibility to irreversibility in glycogen synthase kinase 3 inhibitors: clues for specific design of new compounds

Autor: Carmen Gil, Pablo D. Dans, Ana Martínez, F. Javier Luque, Santiago Conde, Concepción Pérez, Valle Palomo, Daniel I. Perez

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2011, 54 (12), pp.4042-56. ⟨10.1021/jm1016279⟩
Digital.CSIC. Repositorio Institucional del CSIC
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Development of kinase-targeted therapies for central nervous system (CNS) diseases is a great challenge. Glycogen synthase kinase 3 (GSK-3) offers a great potential for severe CNS unmet diseases, being one of the inhibitors on clinical trials for dif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92abbaadba245808bf2575ecb396976a
https://hal-riip.archives-ouvertes.fr/pasteur-00686303

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Dunaliine A, a new amino diketone from Desmos dunalii (Annonaceae)

Autor: Mat Ropi Mukhtar, Khalijah Awang, Marc Litaudon, Noel F. Thomas, A Hamind A Hadi, Zunoliza Abdullah, Faridahanim Mohd Jaafar

Publikováno v: Natural Product Research
Natural Product Research, Taylor & Francis, 2009, 23 (7), pp.652-8. ⟨10.1080/14786410802323743⟩

International audience; Dunaliine A (1), a new amino diketone, has been isolated from the leaves of Desmos dunalii together with four known dihydrochalcones: 2',4-dihydroxy-4',6'-dimethoxy-3',5'-dimethyldihydrochalcone (2), 2',4-dihydroxy-4',6'-dimet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46c167b064354acfb9353d5894748683
https://hal.archives-ouvertes.fr/hal-00433292

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