Výsledky vyhledávání - "MESH: Janus Kinase 3"

IRX-2, a novel immunotherapeutic, protects human T cells from tumor-induced cell death

Autor: Theresa L. Whiteside, Marta Szajnik, H Brandwein, Miroslaw J. Szczepanski, J W Hadden, J Han, K Signorelli, K Quadrini, Malgorzata Czystowska

Publikováno v: Cell Death and Differentiation
Cell Death and Differentiation, 2009, 16 (5), pp.708-18. ⟨10.1038/cdd.2008.197⟩
Cell Death and Differentiation, Nature Publishing Group, 2009, 16 (5), pp.708-18. ⟨10.1038/cdd.2008.197⟩
Cell Death and Differentiation, Nature Publishing Group, 2009, 16 (5), pp.708-18. 〈10.1038/cdd.2008.197〉

International audience; IRX-2 is a cytokine-based biologic agent that has the potential to enhance antitumor immune responses. We investigated whether IRX-2 can protect T cells from tumor-induced apoptosis. Tumor-derived microvesicles (MV) expressing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4405aefc4179838cd033255d4555d7ba
https://doi.org/10.1038/cdd.2008.197

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Persistence of natural killer cells with expansion of a hypofunctional CD56-CD16+KIR+NKG2C+ subset in a patient with atypical Janus kinase 3-deficient severe combined immunodeficiency

Autor: Capucine Picard, Florence Orlanducci, Catherine Farnarier, Daniel Olive, Geneviève de Saint Basile, Alain Fischer, Laure Farnault, Hervé Chambost, Alessandro Moretta, Christophe Picard, Gérard Michel, Isabelle Thuret

Publikováno v: Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology, Elsevier, 2013, 131 (4), pp.1230-3, 1233.e1-2. ⟨10.1016/j.jaci.2012.08.047⟩
Journal of Allergy and Clinical Immunology, 2013, 131 (4), pp.1230-3, 1233.e1-2. ⟨10.1016/j.jaci.2012.08.047⟩
Journal of Allergy and Clinical Immunology, Elsevier, 2013, 131 (4), pp.1230-3, 1233.e1-2. 〈10.1016/j.jaci.2012.08.047〉

International audience

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7daad713f004b04bb5a0c32ce277a75d
https://hal.archives-ouvertes.fr/hal-00870807

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Severe cutaneous papillomavirus disease after haemopoietic stem-cell transplantation in patients with severe combined immune deficiency caused by common gammac cytokine receptor subunit or JAK-3 deficiency

Autor: Christine Bodemer, Jean-Laurent Casanova, Marianne Debré, Marina Cavazzana-Calvo, Gérard Orth, Michel Favre, Stéphane Blanche, Sophie Caillat-Zucman, Geneviève de Saint Basile, Silvia Giliani, Caroline Laffort, Alain Fischer, Isabelle Radford-Weiss, Jean-Pierre de Villartay, Françoise Le Deist, Sylvie Fraitag

Publikováno v: The Lancet
The Lancet, Elsevier, 2004, 363 (9426), pp.2051-4. 〈10.1016/S0140-6736(04)16457-X〉
The Lancet, Elsevier, 2004, 363 (9426), pp.2051-4. ⟨10.1016/S0140-6736(04)16457-X⟩
The Lancet, 2004, 363 (9426), pp.2051-4. ⟨10.1016/S0140-6736(04)16457-X⟩

Haemopoietic stem-cell transplantation is a life-saving treatment for severe combined immune deficiency. However, there has been little long-term follow-up of this treatment. There is evidence for the persistance of partial immunodeficiency associate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d55f3bc984b695a10a9930c4439e2ee
https://hal-pasteur.archives-ouvertes.fr/pasteur-00174776

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Membrane Microdomains and Cytoskeleton Organization Shape and Regulate the IL7-Receptor Signalosome in Human CD4 T-Cells

Autor: Jacques Thèze, Florence Bugault, Ulf Schwarz, Vincent Lavergne, Thierry Rose, Anne-Hélène Pillet, Blanche Tamarit, Pascal Bochet, Nathalie Garin

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2013, 288 (12), pp.8691-8701. ⟨10.1074/jbc.M113.449918⟩
Journal of Biological Chemistry, 2013, 288 (12), pp.8691-8701. ⟨10.1074/jbc.M113.449918⟩

International audience; Interleukin(IL)-7 is the main homeostatic regulator of CD4 T-lymphocytes (helper) at both central and peripheral levels. Upon activation by IL-7, several signalling pathways, mainly Jak/STAT, PI3K/Akt and MAPK, induce the expr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae84103c33230a84c84999f2b220684e
https://hal-pasteur.archives-ouvertes.fr/pasteur-02397495

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