Zobrazeno 1 - 10
of 182
pro vyhledávání: '"MESH: Isoenzymes"'
Autor:
Leonie S. Lautz, Franca M. Buratti, Emma Di Consiglio, Jean-Lou Dorne, Laura Turco, Camille Béchaux, Susanna Vichi, Emanuela Testai, K. Darney
Publikováno v:
Toxicology Letters
Toxicology Letters, Elsevier, 2020, 337, pp.78-90. ⟨10.1016/j.toxlet.2020.11.007⟩
Toxicology Letters, Elsevier, 2020, 337, pp.78-90. ⟨10.1016/j.toxlet.2020.11.007⟩
International audience; The input into the QIVIVE and Physiologically-Based kinetic and dynamic models of drug metabolising enzymes performance and their inter-individual differences significantly improve the modelling performance, supporting the dev
Autor:
Wickenhagen, A, Sugrue, E, Lytras, S, Kuchi, S, Noerenberg, M, Turnbull, ML, Loney, C, Herder, V, Allan, J, Jarmson, I, Cameron-Ruiz, N, Varjak, M, Pinto, RM, Lee, JY, Iselin, L, Palmalux, N, Stewart, DG, Swingler, S, Greenwood, EJD, Crozier, TWM, Gu, Q, Davies, EL, Clohisey, S, Wang, B, Trindade Maranhão Costa, F, Freire Santana, M, de Lima Ferreira, LC, Murphy, L, Fawkes, A, Meynert, A, Grimes, G, Da Silva Filho, JL, Marti, M, Hughes, J, Stanton, RJ, Wang, ECY, Ho, A, Davis, I, Jarrett, RF, Castello, A, Robertson, DL, Semple, MG, Openshaw, PJM, Palmarini, M, Lehner, PJ, Baillie, JK, Rihn, SJ, Wilson, SJ, ISARIC4C Investigators, Carson, G, Alex, B, Bach, B, Barclay, WS, Bogaert, D, Chand, M, Cooke, GS, Docherty, AB, Dunning, J, da Silva Filipe, A, Fletcher, T, Green, CA, Harrison, EM, Ho, AYW, Horby, PW, Ijaz, S, Khoo, S, Klenerman, P, Law, A, Lim, WS, Mentzer, AJ, Merson, L, Meynert, AM, Noursadeghi, M, Moore, SC, Paxton, WA, Pollakis, G, Price, N, Rambaut, A, Russell, CD, Sancho-Shimizu, V, Scott, JT, de Silva, T, Sigfrid, L, Solomon, T, Sriskandan, S, Stuart, D, Summers, C, Tedder, RS, Thomson, EC, Thompson, AAR, Thwaites, RS, Turtle, LCW, Gupta, RK, Palmieri, C, Swann, OV, Zambon, M, Dumas, M-E, Griffin, JL, Takats, Z, Chechi, K, Andrikopoulos, P, Osagie, A, Olanipekun, M, Liggi, S, Lewis, MR, Dos Santos Correia, G, Sands, CJ, Takis, P, Maslen, L, Hardwick, H, Donohue, C, Griffiths, F, Oosthuyzen, W, Donegan, C, Spencer, RG, Norman, L, Pius, R, Drake, TM, Fairfield, CJ, Knight, SR, Mclean, KA, Murphy, D, Shaw, CA, Dalton, J, Girvan, M, Saviciute, E, Roberts, S, Harrison, J, Marsh, L, Connor, M, Halpin, S, Jackson, C, Gamble, C, Plotkin, D, Lee, J, Leeming, G, Wham, M, Hendry, R, Scott-Brown, J, Greenhalf, W, Shaw, V, McDonald, SE, Keating, S, Ahmed, KA, Armstrong, JA, Ashworth, M, Asiimwe, IG, Bakshi, S, Barlow, SL, Booth, L, Brennan, B, Bullock, K, Catterall, BWA, Clark, JJ, Clarke, EA, Cole, S, Cooper, L, Cox, H, Davis, C, Dincarslan, O, Dunn, C, Dyer, P, Elliott, A, Evans, A, Finch, L, Fisher, LWS, Foster, T, Garcia-Dorival, I, Gunning, P, Hartley, C, Jensen, RL, Jones, CB, Jones, TR, Khandaker, S, King, K, Kiy, RT, Koukorava, C, Lake, A, Lant, S, Latawiec, D, Lavelle-Langham, L, Lefteri, D, Lett, L, Livoti, LA, Mancini, M, McDonald, S, McEvoy, L, McLauchlan, J, Metelmann, S, Miah, NS, Middleton, J, Mitchell, J, Murphy, EG, Penrice-Randal, R, Pilgrim, J, Prince, T, Reynolds, W, Ridley, PM, Sales, D, Shaw, VE, Shears, RK, Small, B, Subramaniam, KS, Szemiel, A, Taggart, A, Tanianis-Hughes, J, Thomas, J, Trochu, E, van Tonder, L, Wilcock, E, Zhang, JE, Flaherty, L, Maziere, N, Cass, E, Carracedo, AD, Carlucci, N, Holmes, A, Massey, H, Wrobel, N, McCafferty, S, Morrice, K, MacLean, A, Adeniji, K, Agranoff, D, Agwuh, K, Ail, D, Aldera, EL, Alegria, A, Allen, S, Angus, B, Ashish, A, Atkinson, D, Bari, S, Barlow, G, Barnass, S, Barrett, N, Bassford, C, Basude, S, Baxter, D, Beadsworth, M, Bernatoniene, J, Berridge, J, Berry, C, Best, N, Bothma, P, Chadwick, D, Brittain-Long, R, Bulteel, N, Burden, T, Burtenshaw, A, Caruth, V, Chambler, D, Chee, N, Child, J, Chukkambotla, S, Clark, T, Collini, P, Cosgrove, C, Cupitt, J, Cutino-Moguel, M-T, Dark, P, Dawson, C, Dervisevic, S, Donnison, P, Douthwaite, S, Drummond, A, DuRand, I, Dushianthan, A, Dyer, T, Evans, C, Eziefula, C, Fegan, C, Finn, A, Fullerton, D, Garg, S, Garg, A, Gkrania-Klotsas, E, Godden, J, Goldsmith, A, Graham, C, Hardy, E, Hartshorn, S, Harvey, D, Havalda, P, Hawcutt, DB, Hobrok, M, Hodgson, L, Hormis, A, Jacobs, M, Jain, S, Jennings, P, Kaliappan, A, Kasipandian, V, Kegg, S, Kelsey, M, Kendall, J, Kerrison, C, Kerslake, I, Koch, O, Koduri, G, Koshy, G, Laha, S, Laird, S, Larkin, S, Leiner, T, Lillie, P, Limb, J, Linnett, V, Little, J, Lyttle, M, MacMahon, M, MacNaughton, E, Mankregod, R, Masson, H, Matovu, E, McCullough, K, McEwen, R, Meda, M, Mills, G, Minton, J, Mirfenderesky, M, Mohandas, K, Mok, Q, Moon, J, Moore, E, Morgan, P, Morris, C, Mortimore, K, Moses, S, Mpenge, M, Mulla, R, Murphy, M, Nagel, M, Nagarajan, T, Nelson, M, Norris, L, O'Shea, MK, Otahal, I, Ostermann, M, Pais, M, Panchatsharam, S, Papakonstantinou, D, Paraiso, H, Patel, B, Pattison, N, Pepperell, J, Peters, M, Phull, M, Pintus, S, Singh Pooni, J, Planche, T, Post, F, Price, D, Prout, R, Rae, N, Reschreiter, H, Reynolds, T, Richardson, N, Roberts, M, Roberts, D, Rose, A, Rousseau, G, Ruge, B, Ryan, B, Saluja, T, Schmid, ML, Shah, A, Shanmuga, P, Sharma, A, Shawcross, A, Sizer, J, Shankar-Hari, M, Smith, R, Snelson, C, Spittle, N, Staines, N, Stambach, T, Stewart, R, Subudhi, P, Szakmany, T, Tatham, K, Thompson, C, Thompson, R, Tridente, A, Tupper-Carey, D, Twagira, M, Vallotton, N, Vancheeswaran, R, Vincent-Smith, L, Visuvanathan, S, Vuylsteke, A, Waddy, S, Wake, R, Walden, A, Welters, I, Whitehouse, T, Whittaker, P, Whittington, A, Papineni, P, Wijesinghe, M, Williams, M, Wilson, L, Winchester, S, Wiselka, M, Wolverson, A, Wootton, DG, Workman, A, Yates, B, Young, P
Publikováno v:
2021, ' A prenylated dsRNA sensor protects against severe COVID-19 ', Science (New York, N.Y.) . https://doi.org/10.1126/science.abj3624
Investigators, ISARICC & Dark, P 2021, ' A prenylated dsRNA sensor protects against severe COVID-19 ', Science (New York, N.Y.), vol. 374, no. 6567, eabj3624 . https://doi.org/10.1126/science.abj3624
Science
Science, American Association for the Advancement of Science, 2021, 374 (6567), pp.eabj3624. ⟨10.1126/science.abj3624⟩
Investigators, ISARICC & Dark, P 2021, ' A prenylated dsRNA sensor protects against severe COVID-19 ', Science (New York, N.Y.), vol. 374, no. 6567, eabj3624 . https://doi.org/10.1126/science.abj3624
Science
Science, American Association for the Advancement of Science, 2021, 374 (6567), pp.eabj3624. ⟨10.1126/science.abj3624⟩
International audience; INTRODUCTIONInterferons (IFNs) are cytokines that are rapidly deployed in response to invading pathogens. By initiating a signaling cascade that stimulates the expression of hundreds of genes, IFNs create an antiviral state in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d185dac789dae326bac2a1eff3e76148
https://www.pure.ed.ac.uk/ws/files/235518845/science.abj3624.pdf
https://www.pure.ed.ac.uk/ws/files/235518845/science.abj3624.pdf
Autor:
Joachim Bischof, Timo Burster, Pengfei Xu, Fabian Gärtner, Congxing Liu, Vasiliy A. Bakulev, Uwe Knippschild, Najma Rachidi, Chiara Ianes
Publikováno v:
Gene
Gene, 2019, 715, pp.144005. ⟨10.1016/j.gene.2019.144005⟩
Gene, Elsevier, 2019, 715, pp.144005. ⟨10.1016/j.gene.2019.144005⟩
Gene, 2019, 715, pp.144005. ⟨10.1016/j.gene.2019.144005⟩
Gene, Elsevier, 2019, 715, pp.144005. ⟨10.1016/j.gene.2019.144005⟩
International audience; Members of the highly conserved pleiotropic CK1 family of serine/threonine-specific kinases are tightly regulated in the cell and play crucial regulatory roles in multiple cellular processes from protozoa to human. Since their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b55c9cdedeeafee4a833888ef22f8936
https://hal-pasteur.archives-ouvertes.fr/pasteur-02874586
https://hal-pasteur.archives-ouvertes.fr/pasteur-02874586
Autor:
Thibaut Vazeille, Pierre Sonveaux, Vincent F. Van Hée, Paolo E. Porporato, Tamara Copetti, Morgane Tardy, Lucie Brisson, Piotr Bański, Caroline Bouzin, Pierre Danhier, Raphaël Frédérick, Jorge Falces, Carine Michiels, Martina Sboarina, Coralie Dethier, Marie Joséphine Fontenille
Publikováno v:
Cancer Cell
Cancer Cell, Elsevier, 2016, 30 (3), pp.418-431. ⟨10.1016/j.ccell.2016.08.005⟩
Cancer Cell, Elsevier, 2016, 30 (3), pp.418-431. ⟨10.1016/j.ccell.2016.08.005⟩
Metabolic adaptability is essential for tumor progression and includes cooperation between cancer cells with different metabolic phenotypes. Optimal glucose supply to glycolytic cancer cells occurs when oxidative cancer cells use lactate preferential
Autor:
Schlattner, Uwe, Wallimann, Theo
Publikováno v:
Journal of Bioenergetics
Journal of Bioenergetics, 2000, 32 (1), pp.123-31. ⟨10.1023/A:1005576831968⟩
Journal of Bioenergetics, 2000, 32 (1), pp.123-31. ⟨10.1023/A:1005576831968⟩
International audience; We have evaluated surface plasmon resonance with avidin-biotin immobilized liposomes to characterize membrane binding of ubiquitous mitochondrial creatine kinase (uMtCK). While the sarcomeric sMtCK isoform is well known to bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8d413701125149ae8d561f189cbdf329
http://doc.rero.ch/record/312341/files/10863_2004_Article_223810.pdf
http://doc.rero.ch/record/312341/files/10863_2004_Article_223810.pdf
Publikováno v:
International Journal of Cancer
International Journal of Cancer, Wiley, 2015, 137 (1), pp.61-72. ⟨10.1002/ijc.29373⟩
International Journal of Cancer, Wiley, 2015, 137 (1), pp.61-72. ⟨10.1002/ijc.29373⟩
International audience; The E5 oncoprotein of the human papillomavirus type 16 (HPV16 E5) deregulates epithelial homeostasis through the modulation of receptor tyrosine kinases and their signaling. Accordingly, the fibroblast growth factor receptor 2
Publikováno v:
International Journal of Developmental Biology
International Journal of Developmental Biology, University of the Basque Country Press, 2017, 61 (10-11-12), pp.733-747. ⟨10.1387/ijdb.170227ms⟩
International Journal of Developmental Biology, University of the Basque Country Press, 2017, 61 (10-11-12), pp.733-747. ⟨10.1387/ijdb.170227ms⟩
International audience; During development, morphogens, such as retinoic acid (RA), act as mediators of intercellular communication systems to control patterning and cell fate specification processes. In vertebrates, the tightly regulated production
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68a10f8f7db29d0e2a1a58a5ebe43967
https://hal.archives-ouvertes.fr/hal-02110617/document
https://hal.archives-ouvertes.fr/hal-02110617/document
Autor:
Christian Brambilla, Patrick Auberger, Marie-Christine Favrot, Jean-Luc Coll, Amandine Hurbin, Laurence Dubrez-Daloz, Bernard Mari
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2005, 280 (20), pp.19757-67. 〈10.1074/jbc.M413516200〉
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2005, 280 (20), pp.19757-67. ⟨10.1074/jbc.M413516200⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2005, 280 (20), pp.19757-67. 〈10.1074/jbc.M413516200〉
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2005, 280 (20), pp.19757-67. ⟨10.1074/jbc.M413516200⟩
International audience; Amphiregulin (AR) and insulin-like growth factor-1 (IGF1) are growth factors known to promote non-small cell lung cancer (NSCLC) survival. We have previously published that 1) AR and IGF1, secreted by H358 NSCLC cells, coopera
Publikováno v:
Gene expression patterns : GEP.
Gene expression patterns : GEP., 2013, 13 (7), pp.203-11. ⟨10.1016/j.gep.2013.04.002⟩
Gene expression patterns : GEP., 2013, 13 (7), pp.203-11. ⟨10.1016/j.gep.2013.04.002⟩
International audience; Pfkfb (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) enzymes are bi-functional enzymes encoded by four different genes (pfkfb1, pfkfb2, pfkfb3, pfkfb4) in vertebrates. They are involved in the regulation of glycolysis:
Autor:
B. Fisser, C. Chotard, Suzanne Trottier, Dick F. Swaab, J.-C. Schwartz, Unga A. Unmehopa, Elisabeth Traiffort
Publikováno v:
Brain Research, 939, 52-64. Elsevier B.V.
Brain Research
Brain Research, Elsevier, 2002, 939 (1-2), pp.52-64
Brain research, 939(1-2), 52-64. Elsevier
Brain Research
Brain Research, Elsevier, 2002, 939 (1-2), pp.52-64
Brain research, 939(1-2), 52-64. Elsevier
International audience; The presence of GABA and galanin in histaminergic neurons was previously reported in the rodent brain but whether such co-localizations also occur in the human brain was not known. We used in situ hybridization histochemistry