Výsledky vyhledávání - "MESH: Iron-Binding Proteins"

Frataxin deficiency alters heme pathway transcripts and decreases mitochondrial heme metabolites in mammalian cells

Autor: Bo Lönnerdal, Michael Ristow, Alan R. Buckpitt, Robert Schoenfeld, Alice Wong, Hélène Puccio, Eleonora Napoli, Shan Zhan, Franco Taroni, Laurence Reutenauer, Dexter Morin, Gino A Cortopassi

Publikováno v: Human Molecular Genetics
Human Molecular Genetics, Oxford University Press (OUP), 2005, 14 (24), pp.3787-99. ⟨10.1093/hmg/ddi393⟩

International audience; Deficiency of the frataxin mRNA alters the transcriptome, triggering neuro- and cardiodegeneration in Friedreich's ataxia. We microarrayed murine frataxin-deficient heart tissue, liver tissue and cardiocytes and observed a tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::423543045f02c60929eda695ff8bc85a
https://doi.org/10.1093/hmg/ddi393

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The kinetics of folding of frataxin

Autor: Annalisa Pastore, Angelo Toto, Angela Morrone, Stefano Gianni, Daniela Bonetti, Rajanish Giri, Maurizio Brunori, Pierandrea Temussi, Domenico Sanfelice

Publikováno v: Physical Chemistry Chemical Physics
Physical Chemistry Chemical Physics, Royal Society of Chemistry, 2014, 16 (14), pp.6391-7. <10.1039/c3cp54055c>
Physical Chemistry Chemical Physics, Royal Society of Chemistry, 2014, 16 (14), pp.6391-7. ⟨10.1039/c3cp54055c⟩

The role of the denatured state in protein folding represents a key issue for the proper evaluation of folding kinetics and mechanisms. The yeast ortholog of the human frataxin, a mitochondrial protein essential for iron homeostasis and responsible f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aaea8b5808cbf8e07b7cf73cf4249e5
https://pubmed.ncbi.nlm.nih.gov/24429875

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Mammalian frataxin controls sulfur production and iron entry during de novo Fe4S4 cluster assembly

Autor: Adeline Page, Martin Clémancey, Sandrine Ollagnier de Choudens, Serge Gambarelli, Alain Martelli, Catherine Birck, Florent Colin, Hélène Puccio, Jean-Marc Latour, Laura Zeppieri

Publikováno v: Journal of the American Chemical Society
Journal of the American Chemical Society, American Chemical Society, 2013, 135 (2), pp.733-40. ⟨10.1021/ja308736e⟩
Journal of the American Chemical Society, 2013, 135 (2), pp.733-40. ⟨10.1021/ja308736e⟩
Journal of the American Chemical Society; Vol 135

International audience; Iron-sulfur (Fe-S) cluster-containing proteins are essential components of cells. In eukaryotes, Fe-S clusters are synthesized by the mitochondrial iron-sulfur cluster (ISC) machinery and the cytosolic iron-sulfur assembly (CI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cea1f469d601a252fc2d5e0f0d0b2167
https://hal.archives-ouvertes.fr/hal-01054359

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Light-induced retinal degeneration correlates with changes in iron metabolism gene expression, ferritin level, and aging

Autor: Jean-Claude Jeanny, Laurent Jonet, Isabelle Ranchon-Cole, Francine Behar-Cohen, Carole Beaumont, Yves Courtois, Emilie Picard

Publikováno v: Investigative Ophthalmology & Visual Science
Investigative Ophthalmology & Visual Science, 2011, 52 (3), pp.1261. ⟨10.1167/iovs.10-5705⟩
Investigative Ophthalmology & Visual Science, Association for Research in Vision and Ophthalmology, 2011, 52 (3), pp.1261. ⟨10.1167/iovs.10-5705⟩

International audience; Purpose: Retinal degeneration is associated with iron accumulation in several rodent models in which iron-regulating proteins are impaired. Oxidative stress is catalyzed by unbound iron.Methods: The role of the heavy chain of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32837bfc6abf1d776bf1f55af28072e2
https://pubmed.ncbi.nlm.nih.gov/20881284

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Early effects of erythropoietin on serum hepcidin and serum iron bioavailability in healthy volunteers

Autor: Olivier Loréal, Fabrice Lainé, Martine Ropert, Guillaume Bouguen, Jeff Morcet, Yves Deugnier, Bruno Laviolle, Mark Westermann, Catherine Massart, Catherine Hamon

Publikováno v: European Journal of Applied Physiology
European Journal of Applied Physiology, 2012, 112 (4), pp.1391-7. ⟨10.1007/s00421-011-2097-7⟩
European Journal of Applied Physiology, Springer Verlag, 2012, 112 (4), pp.1391-7. ⟨10.1007/s00421-011-2097-7⟩

International audience; Hepcidin regulates plasma iron bioavailability and subsequently iron availability for erythropoiesis. rHuEPO has been reported to decrease hepcidin expression in case of repeated subcutaneous injections. Thus, hepcidin level m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2890a7be9de4d939746cd091e6d4867a
https://pubmed.ncbi.nlm.nih.gov/21818622

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Overexpression of the yeast frataxin homolog (Yfh1): contrasting effects on iron-sulfur cluster assembly, heme synthesis and resistance to oxidative stress

Autor: Alexandra Seguin, Anne-Laure Bulteau, Aurélien Bayot, Andrew Dancis, Adelina Rogowska-Wrzesinska, Emmanuel Lesuisse, Jean-Michel Camadro, Françoise Auchère

Publikováno v: Mitochondrion
Mitochondrion, Elsevier, 2009, 9 (2), pp.130-8. ⟨10.1016/j.mito.2009.01.007⟩
Seguin, A, Bayot, A, Dancis, A, Rogowska-Wrzesinska, A, Auchère, F, Camadro, J-M, Bulteau, A-L & Lesuisse, E 2009, ' Overexpression of the yeast frataxin homolog (Yfh1): contrasting effects on iron-sulfur cluster assembly, heme synthesis and resistance to oxidative stress ', Mitochondrion, vol. 9, no. 2, pp. 130-138 . https://doi.org/10.1016/j.mito.2009.01.007

Udgivelsesdato: 2009-Apr Friedreich's ataxia is generally associated with defects in [Fe-S] cluster assembly/stability and heme synthesis and strong susceptibility to oxidative stress. We used the yeast (Saccharomyces cerevisiae) model of Friedreich'

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::208bdd6b670de75fd6aec016e46014ce
https://hal.archives-ouvertes.fr/hal-00503012

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Multicellular models of Friedreich ataxia

Autor: Hélène Puccio

Publikováno v: Deutsche Zeitschrift für Nervenheilkunde / Deutsche Zeitschrift f ur Nervenheilkunde
Deutsche Zeitschrift für Nervenheilkunde / Deutsche Zeitschrift f ur Nervenheilkunde, 2009, 256 Suppl 1, pp.18-24. ⟨10.1007/s00415-009-1004-1⟩

International audience; Patients with Friedreich ataxia (FRDA) have severely reduced levels of the mitochondrial protein frataxin, which results from a large GAA triplet-repeat expansion within the frataxin gene (FXN). High evolutionary conservation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cb0afdb6219b41116a3bde3311969d7
https://www.hal.inserm.fr/inserm-00384533

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Neurological, cardiological, and oculomotor progression in 104 patients with Friedreich ataxia during long-term follow-up

Autor: Pascale Ribai, Alain Mallet, Marie-Laure Tanguy, Anne-Sophie Béraud, Michèle Schmitt, Alexandra Durr, Perrine Charles, Françoise Pousset, Michel Koenig, Alexis Brice, Sophie Rivaud-Péchoux, Franchesca Gasparini, Isabelle Le Ber

Publikováno v: Archives of Neurology-Chigago
Archives of Neurology-Chigago-, American Medical Association, 2007, 64 (4), pp.558-64. ⟨10.1001/archneur.64.4.558⟩
Archives of Neurology-Chigago-, 2007, 64 (4), pp.558-64. ⟨10.1001/archneur.64.4.558⟩

BACKGROUND: Friedreich ataxia (FA) is the most frequent autosomal recessive cerebellar ataxia. Although the phenotype is well known, disease progression has not been evaluated in a prospective manner. OBJECTIVE: To perform a long-term prospective fol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40cca0763597016a49acd2f51431ee54
https://hal.archives-ouvertes.fr/hal-00166262

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An archaeal orthologue of the universal protein Kae1 is an iron metalloprotein which exhibits atypical DNA-binding properties and apurinic-endonuclease activity in vitro

Autor: Danièle Gadelle, Herman van Tilbeurgh, Sophie Quevillon-Cheruel, Eric Le Cam, Nicolas Leulliot, Anthony Justome, Pierre Dorlet, Céline Brochier, Arnaud Hecker, Marc Graille, Patrick Forterre

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, 2007, 35 (18), pp.6042-51. ⟨10.1093/nar/gkm554⟩
Nucleic Acids Research, Oxford University Press, 2007, 35 (18), pp.6042-6051. ⟨10.1093/nar/gkm554⟩
Nucleic Acids Research, Oxford University Press, 2007, 35 (18), pp.6042-51. ⟨10.1093/nar/gkm554⟩
Nucleic Acids Research, Oxford University Press, 2007, 35, pp.6042-51

The Kae1 (Kinase-associated endopeptidase 1) protein is a member of the recently identified transcription complex EKC and telomeres maintenance complex KEOPS in yeast. Kae1 homologues are encoded by all sequenced genomes in the three domains of life.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81d4a0fdc70f3e66467893e3d9280b2e
https://hal.science/hal-00195238

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Acute study of interaction among cadmium, calcium, and zinc transport along the rat nephron in vivo

Autor: Michel Tauc, Grégory Jacquillet, Marc Cougnon, Philippe Poujeol, Olivier Barbier

Publikováno v: AJP Renal Physiology
AJP Renal Physiology, American Physiological Society, 2004, 287 (5), pp.F1067-75. ⟨10.1152/ajprenal.00120.2004⟩

This study investigates the effect in rats of acute CdCl2(5 μM) intoxication on renal function and characterizes the transport of Ca2+, Cd2+, and Zn2+in the proximal tubule (PT), loop of Henle (LH), and terminal segments of the nephron (DT) using wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a660a7421c24f471a26204041a2d8abe
https://hal.archives-ouvertes.fr/hal-00320807

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