Th22 cells are efficiently recruited in the gut by CCL28 as an alternative to CCL20 but do not compensate for the loss of Th17 cells in treated HIV-1-infected individuals

Autor: Guillaume Martin-Blondel, Jacques Izopet, Mary Requena, Bertrand Suc, Laurent Alric, Manon Nayrac, Nicolas Carrere, Pierre Delobel, Karl Barange, Claire Loiseau, Michelle Cazabat

Publikováno v: Mucosal Immunology
Mucosal Immunology, 2020, 14 (1), pp.219-228. ⟨10.1038/s41385-020-0286-6⟩
Mucosal Immunology, Nature Pub. Group, 2021, 14 (1), pp.219-228. ⟨10.1038/s41385-020-0286-6⟩

International audience; Gut CD4+ T cells are incompletely restored in most HIV-1-infected individuals on antiretroviral therapy, notably Th17 cells, a key subset in mucosal homeostasis. By contrast, gut Th22 cells are usually restored at normal frequ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7063cc54ac3d26c97d0c23435a80444c
https://ut3-toulouseinp.hal.science/hal-03157449

Yersiniabactin siderophore of Crohn’s disease-associated adherent-invasive Escherichia coli Is Involved in autophagy activation in host cells

Autor: Nicolas Barnich, Sébastien Massier, Richard Bonnet, Emilie Vazeille, Guillaume Dalmasso, Hang Thi Thu Nguyen, Tiphanie Faïs, Julien Delmas, Caroline Chevarin

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, 2021, 22 (7), pp.1-17. ⟨10.3390/ijms22073512⟩
Volume 22
Issue 7
International Journal of Molecular Sciences, MDPI, 2021, 22 (7), pp.1-17. ⟨10.3390/ijms22073512⟩
International Journal of Molecular Sciences, Vol 22, Iss 3512, p 3512 (2021)

International audience; Background: Adherent-invasive Escherichia coli (AIEC) have been implicated in the etiology of Crohn’s disease. The AIEC reference strain LF82 possesses a pathogenicity island similar to the high pathogenicity island of Yersi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db510b8b2134c43de93c97c733caef56
https://hal.inrae.fr/hal-03318629

Smarcad1 mediates microbiota-induced inflammation in mouse and coordinates gene expression in the intestinal epithelium

Autor: J. Ross Miller, Anke Liebert, Claire Fraser, Mariana Portovedo, Marco Aurélio Ramirez Vinolo, Raphaël Mattiuz, Payal Jain, Marc Veldhoen, Claudia Stellato, Juri Kazakevych, Patrick Varga-Weisz, Jérémy Denizot, Marina Célestine, Mia Mosavie, Hanneke Okkenhaug, Renan O. Corrêa

Publikováno v: Genome Biology
Genome Biology, BioMed Central, 2020, 21 (1), pp.1-20. ⟨10.1186/s13059-020-01976-7⟩
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Genome Biology, Vol 21, Iss 1, Pp 1-20 (2020)
Genome Biology, BioMed Central, 2020, 21 (1), ⟨10.1186/s13059-020-01976-7⟩

© The Author(s). 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2883207d3055b5f3970d25e825e643a8
https://hal.inrae.fr/hal-02541660/document

The HSP90/R2TP assembly chaperone promotes cell proliferation in the intestinal epithelium

Autor: Marina Ferrand, Edouard Bertrand, Bénédicte Lemmers, Claire Abeza, Francina Langa, Conception Paul, Céline Verheggen, Valérie Pinet, Dominique Helmlinger, Bérengère Pradet-Balade, Rossano Lattanzio, Ciro Longobardi, Michael Hahne, Philippe Jay, François Gerbe, Monica Gabola, Julie Bremond, Chloé Maurizy, Nicola Tinari

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications
Nature Communications, 2021, 12 (1), pp.4810. ⟨10.1038/s41467-021-24792-4⟩
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.4810. ⟨10.1038/s41467-021-24792-4⟩

The R2TP chaperone cooperates with HSP90 to integrate newly synthesized proteins into multi-subunit complexes, yet its role in tissue homeostasis is unknown. Here, we generated conditional, inducible knock-out mice for Rpap3 to inactivate this core c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66a684d2b37d0731f7bbb1ca0f5ddd57
https://pubmed.ncbi.nlm.nih.gov/36261420

Early Antiretroviral Therapy Preserves Functional Follicular Helper T and HIV-Specific B Cells in the Gut Mucosa of HIV-1-Infected Individuals

Autor: Valérie Lorin, Mathieu Surenaud, Cyril Planchais, Hugo Mouquet, Mathieu Fusaro, Sophie Hue, Marie-Hélène Delfau-Larue, Nabila Seddiki, Clara Ibanez, Laurent Hocqueloux, Michael J. Levy, Thierry Prazuck, S. Gallien, Yves Levy, Ayrin Kök, Christiane Copie, Jean-Daniel Lelièvre, Laurent Lefrou

Publikováno v: Journal of Immunology
Journal of Immunology, 2018, 200 (10), pp.3519-3529. ⟨10.4049/jimmunol.1701615⟩
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2018, 200 (10), pp.3519-3529. ⟨10.4049/jimmunol.1701615⟩

HIV-1 infection is associated with B cell dysregulation and dysfunction. In HIV-1–infected patients, we previously reported preservation of intestinal lymphoid structures and dendritic cell maturation pathways after early combination antiretroviral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2622102e5901a8a1bf6c99603c6ba9c4
https://hal-pasteur.archives-ouvertes.fr/pasteur-02634634/document