Organ preservation with chemoradiotherapy plus local excision for rectal cancer: 5-year results of the GRECCAR 2 randomised trial

Autor: Anne Dubois, Jean-Jacques Tuech, Philippe Rouanet, M. Bertrand, Anne Rullier, Marc Pocard, Quentin Denost, Véronique Vendrely, Bertrand Trilling, Mehrdad Jafari, Alain Valverde, G. Portier, Cécile de Chaisemartin, Nora Frulio, Julien Asselineau, Eric Frison, Denis Smith, Eric Rullier, Bernard Meunier, Michel Rivoire, Igor Sieleznieff, Frédéric Marchal

Publikováno v: The Lancet Gastroenterology and Hepatology
The Lancet Gastroenterology and Hepatology, Elsevier, 2020, 5 (5), pp.465-474. ⟨10.1016/S2468-1253(19)30410-8⟩
The Lancet Gastroenterology & Hepatology
The Lancet Gastroenterology & Hepatology, 2020, 5 (5), pp.465-474. ⟨10.1016/S2468-1253(19)30410-8⟩

Summary Background GRECCAR 2 was the first multicentre, randomised trial to compare local excision with total mesorectal excision in downstaged low rectal cancer. Encouraging oncological results were noted at 3 years' follow-up but needed to be corro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f8da1081b07e9eba901accb3a0227c
https://hal.umontpellier.fr/hal-03350581

mTOR Inhibition Is Most Beneficial After Liver Transplantation for Hepatocellular Carcinoma in Patients With Active Tumors

Autor: Antonio Daniele Pinna, Natalie Filmann, Lionel Rostaing, Jens Brockmann, Michael Heise, Andreas A. Schnitzbauer, Simone I. Strasser, Giorgio Rossi, Silvio Nadalin, Jean Gugenheim, Tom M. Ganten, Umberto Cillo, Norman M. Kneteman, Koert P. de Jong, André Roy, Víctor Sánchez Turrión, Thomas Becker, Christoph Duvoux, Markus Rentsch, Jürgen Klempnauer, Utz Settmacher, George Philippe Pageaux, Christian Klein, Roberto Troisi, Edward K. Geissler, Darius F. Mirza, Gunnar Söderdahl, Peter Neuhaus, Jan Lerut, Hans J. Schlitt, Patrizia Burra, Vincenzo Mazzaferro, Johann Pratschke, T. Scholz, Neville V. Jamieson, Wolf O. Bechstein, James Powel, Thomas Soliman, Heikki Mäkisalo, Magnus Rizell, René Adam, Bart van Hoek, Michele Colledan, Itxarone Bilbao, Philippe Bachellier, Olivier Chazoullières, Sherrie Bhoori, Jaques Pirenne

Publikováno v: Annals of Surgery, Vol. 272, no. 5, p. 855-862 (2020)
Annals of Surgery
Annals of Surgery, Lippincott, Williams & Wilkins, 2020, 272 (5), pp.855-862. ⟨10.1097/SLA.0000000000004280⟩
Annals of Surgery, 272(5), 855-862. LIPPINCOTT WILLIAMS & WILKINS
Annals of Surgery, 2020, 272 (5), pp.855-862. ⟨10.1097/SLA.0000000000004280⟩

OBJECTIVE: The aim of this study was to evaluate the survival benefit of sirolimus in patients undergoing liver transplantation (LT) for hepatocellular carcinoma (HCC) (exploratory analysis of the SiLVER-trial). SUMMARY AND BACKGROUND DATA: Patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1366a5a25685c35d3e6bad9d9a449956
https://hdl.handle.net/2078.1/235479

Extended use of dabigatran, warfarin, or placebo in venous thromboembolism

Autor: Schulman, S1, Kearon, C, Kakkar, AK, Schellong, S, Eriksson, H, Baanstra, D, Kvamme, AM, Friedman, J, Mismetti, P, Goldhaber, SZ, Schulman, S, Goldhaber, S, Kakkar A, DI MINNO, GIOVANNI

Publikováno v: New England journal of medicine, 368(8), 709-718. Massachussetts Medical Society
New England Journal of Medicine
New England Journal of Medicine, Massachusetts Medical Society, 2013, 368 (8), pp.709-18. ⟨10.1056/NEJMoa1113697⟩
Schulman, S, Kearon, C, Kakkar, A K, Schellong, S, Eriksson, H, Baanstra, D, Kvamme, A M, Friedman, J, Nurmohamed, M T, Mismetti, P & Goldhaber, S Z 2013, ' Extended use of dabigatran, warfarin, or placebo in venous thromboembolism. ', New England Journal of Medicine, vol. 368, no. 8, pp. 709-718 . https://doi.org/10.1056/NEJMoa1113697
New England Journal of Medicine, 368(8), 709-718. Massachussetts Medical Society
Schulman, S, Kearon, C, Kakkar, A K, Schellong, S, Eriksson, H, Baanstra, D, Kvamme, A M, Friedman, J, Mismetti, P, Goldhaber, S Z & RE-MEDY Trial Investigators 2013, ' Extended use of dabigatran, warfarin, or placebo in venous thromboembolism ', The New England Journal of Medicine, vol. 368, no. 8, pp. 709-18 . https://doi.org/10.1056/NEJMoa1113697

International audience; BACKGROUND: Dabigatran, which is administered in a fixed dose and does not require laboratory monitoring, may be suitable for extended treatment of venous thromboembolism. METHODS: In two double-blind, randomized trials, we co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49c6d84e6bef3f708aafee8a518c7246
http://hdl.handle.net/10447/96631

Enoxaparin followed by once-weekly idrabiotaparinux versus enoxaparin plus warfarin for patients with acute symptomatic pulmonary embolism: a randomised, double-blind, double-dummy, non-inferiority trial

Autor: Büller, Hr, Gallus, As, Prins, Mh, Raskob, G, Decousus, H, Charbonnier, B, Leizorovicz, A, Laporte, S, Quenet, S, Brandjes, Dp, Middeldorp, S, Blüguermann, J, Amuchastegui, L, Ahuad Guerrero, R, Oberti, P, Alvarez, C, Cassettari, A, Santos, D, Macin, S, Santini, F, Ward, C, Coughlin, P, Salem, H, Gan, E, Leyden, M, Prosser, I, Crispin, P, Carroll, P, Gallus, A, Mcrae, S, Waites, J, Pilger, E, Koppensteiner, R, Kyrle, P, Schinko, H, Mrochek, A, Mitkovskaya, N, Prystrom, A, Motte, S, Ninane, V, Delcroix, M, Hainaut, P, Schneider, E, Saraiva, J, Maia, L, Barreto, S, Fernandes Manenti, E, Araujo, G, Dutra, O, Fiss, E, Moreira, R, Yankov, K, Nenkova, S, Ivanov, Y, Kostov, V, Bhargava, R, Chan, Y, Miron, Mj, Cusson, J, Ugarte, S, Morales, A, Andresen, M, Lanas, F, Arriagada, G, Mendoza, Jj, Zuñiga, C, Sepulveda, P, Wang, C, Liu, Z, Yuan, Y, Ma, Z, Fang, B, Liu, J, Bai, C, Wu, H, Yang, L, Ying, K, Kang, J, Li, Q, Cheng, Z, Zhang, J, Wang, H, Xie, C, Xia, G, Du, Y, Wu, Q, Zhou, X, Chen, L, Yi, Q, Wu, C, Hao, Q, Liu, S, Xiong, S, Jiang, S, Zhao, L, Xiao, Q, Qin, Z, Zhou, J, Dennis, R, Miserque, N, Igueredo, M, Londoño, D, Hildebrando, J, Granados, M, Buitrago, R, Solano, Mh, Pacheco Alvis PM, Botero, R, Saenz, O, Bergovec, M, Padovan, M, Vucic, N, Samarzija, M, Chlumsky, J, Spacek, R, Klimsa, Z, Gregor, P, Povolny, J, Podpera, I, Holm, F, Lang, P, Matoska, P, Sabl, P, Spinar, J, Spac, J, Husted, S, Avnstrom, S, Rasmussen, S, Christensen, A, Guindy, R, Hassanein, M, Paumets, M, Meriste, S, Ferrari, E, Achkar, A, Azarian, R, Meneveau, N, Lorut, C, Mouallem, J, Crestani, B, Proton, A, Salmeron, S, Lerousseau, L, Mottier, D, Wahl, D, Siafakas, N, Papadimitriou, D, Katis, K, Katsaris, G, Gaga, A, Damianos, A, Tipparaju, S, Kalkunte, S, Vidhut, J, Kalashetti, S, Mehta, P, Talwar, D, Ramanathan, R, Mishra, R, Zeltzer, D, Lahav, M, Brenner, B, Caraco, Y, Elias, M, Piovella, F, Barone, M, Poggio, R, Palla, A, Ghirarduzzi, A, Pini, M, Lodigiani, C, Prandoni, Paolo, Agnelli, G, Imberti, D, Scannapieco, G, Salvi, A, Bautista, E, Diaz, J, Mercado, R, Ranero, A, Rodriguez, D, Jerjes, C, Villeda Espinoza, E, Van Der Meer, J, Ijfering, W, Van Marwijk Kooy, M, Boersma, W, Van Leendert, R, Kroon, C, Dullemond Westland, A, Viergever, P, Kuipers, A, Grootenboers, M, Creemers, J, Pieters, W, De Munck, D, Timmer, H, Jackson, S, Sandset, P, Meyer, P, Kristiansen, T, Portugal, J, Paz, E, Salazar, D, Chavez, W, Castillo, L, De Guia, T, Lenora, F, Tomkowski, W, Kloczko, J, Rybak, Z, Gaciong, Z, Sobkowicz, B, Pruszczyk, P, Nizankowski, R, Mirek Bryniarska, E, Kukla, P, Reis, A, França, A, Cortez, M, Sa, J, Santos, F, Marques, Ma, Gordeev, I, Gendlin, G, Yablonsky, P, Sokurenko, G, Soroka, V, Lusov, V, Markov, V, Shvats, Y, Katerlnitskiy, I, Lapin, O, Lyamina, N, Subbotin, Y, Kim, I, Zilber, E, Kchaisheva, L, Poliacik, P, Macek, V, Pretorius, Jp, Abdullah, I, Basson, M, Bollinger, C, Breedt, J, Gani, M, Jansen, J, Le Roux, G, Nortje, H, Van Der Linder, M, Van Zyl, L, Viljoen, J, Bruning, A, Pujol Farriols, R, Raguer, E, Nuffal, D, Sanchez Rodriguez, A, Eriksson, H, Almgren, T, Carlsson, A, Elf, J, Olsson, Cg, Aagesen, J, Savas, I, Sahin, A, Erdogan, Y, Ozhan, M, Ongen, G, Celikel, T, Turker, H, Arseven, O, Tuncay, E, Ozacar, R, Gudz, I, Nykonenko, O, Skupyy, O, Kovalskyy, I, Prasol, V, Cohen, A, Rodriguez Cintron, W, Gurka, D, Bradley, J, Oliver, G, Spyropoulos, A, Lerner, R, Fulmer, J, Lu, Np, Wright, P, Han, D, Servi, R, Nadar, V, Quaranta, A, Gehring, J, Ginsberg, R, Jacobson, A, Colan, D, Vanway, C, Gurza, E, Braslow, B, Shorr, A, Rehm, J, Martin, J, Sellers, M, Concha, M, Gordon, I, Pullman, J, Moran, J, Welker, J, Panzarella, P, Mullins, M, Willms, D, Mcgrew, F, Turki, M, Menajovsky, L.

Publikováno v: Lancet, 379(9811), 123-129. Elsevier Science
Lancet, 379(9811), 123-129. Elsevier Limited
Lancet
Lancet, Elsevier, 2012, 379 (9811), pp.123-9. ⟨10.1016/S0140-6736(11)61505-5⟩

International audience; BACKGROUND: Treatment of pulmonary embolism with low-molecular-weight heparin and vitamin K antagonists, such as warfarin, is not ideal. We aimed to assess non-inferiority of idrabiotaparinux, a reversible longlasting indirect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2cef81233461dd5dcb497955b4d24c6
https://cris.maastrichtuniversity.nl/en/publications/70fa0a5d-d76f-4e74-9002-0f44cf51ae9f

Basal insulin and cardiovascular and other outcomes in dysglycemia

Autor: David Clayton, Robert Cuddihy, Jose Antônio Marin-Neto, Esra Hatipoglu, Mohd Shazli Draman, Alfredo Ramirez, Philip Böhme, Victor Gurevich, Miguel Urina, Angel L. Fernández, Maja Cigrovski Berkovic, Valdis Pirags, Evgeny Shkolnik, Alexander Vonbank, Salim Yusuf, Heather Lochnan, Jan Cornel, Bu Yeap, Tatiana Adasheva, Giuseppe Derosa, Aldo Pietro Maggioni, ALVARO AVEZUM, Igor Bondarenko, Monica Acevedo, Francesco Cacciatore, A.S. Ametov, Weiping Jia, Anders Waldenström, B. L. Gregoire Nyomba, Neslihan Bascil Tutuncu, Tristan Richardson, Anastasia F Hutchinson, Vladimir Zadionchenko, Sudeep K, Moti Kashyap, Adrian Vlad, Aivars Lejnieks, Jeong-Taek Woo, Fernando Lanas, Nicolae Hancu, Kurt Boman, Cristina Facanha, Laura Bryan, Louise Bordeleau, Patricio Lopez-Jaramillo, Adriana Forti, Flavia Lucia Lombardo, Gunnar Gislason, Malgorzata Sikora-Frac, Peter Colman, Veronique Kerlan, Olga Bulkina, Melanie Davies, JAIME CARMONA-HUERTA, Hertzel Gerstein, Jackie Bosch, Carlos Morillo, Alina Babenko, Philip Aylward, SONIA GAZTAMBIDE, Yury Vasyuk, Asem Ali, Ragnar Martin Joakimsen, Anna Novials, Andrzej Budaj, Anne Taylor

Publikováno v: New England Journal of Medicine
New England Journal of Medicine, Massachusetts Medical Society, 2012, 367 (4), pp.319-28. ⟨10.1056/NEJMoa1203858⟩
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

International audience; BACKGROUND: The provision of sufficient basal insulin to normalize fasting plasma glucose levels may reduce cardiovascular events, but such a possibility has not been formally tested. METHODS: We randomly assigned 12,537 peopl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::634f88b8e1e558a67f133168a51ce3b3
http://hdl.handle.net/11577/2533486