Výsledky vyhledávání - "MESH: Integrin alpha5beta1"

β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments

Autor: Reinhard Fässler, Zhiqi Sun, Julien Polleux, Michaela-Rosemarie Hermann, Timothée Vignaud, Caroline C. Friedel, Manuel Théry, Herbert B. Schiller, Sara Zanivan, Matthias Mann, Aurelia Raducanu, Kay-E. Gottschalk

Publikováno v: Nature Cell Biology
Nature Cell Biology, Nature Publishing Group, 2013, 15 (6), pp.625-36. ⟨10.1038/ncb2747⟩
Nature Cell Biology, 2013, 15 (6), pp.625-36. ⟨10.1038/ncb2747⟩

Supplementary information; International audience; How different integrins that bind to the same type of extracellular matrix protein mediate specific functions is unclear. We report the functional analysis of β1- and αv-class integrins expressed i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8712a7191a162fed92784e0445649d2e
https://pubmed.ncbi.nlm.nih.gov/23756622

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Integrin α5β1 plays a critical role in resistance to temozolomide by interfering with the p53 pathway in high-grade glioma

Autor: Jacqueline Lehmann-Che, Pascal Chastagner, Hana Janouskova, Catherine Bossert, Sophie Martin, Jan Teisinger, Dominique Guenot, Eric Guérin, Anne Maglott, David Y. Leger, Sophie Pinel, Fanny Noulet, François Plénat, Julien Godet, Monique Dontenwill, Natacha Entz-Werle

Publikováno v: Cancer Research
Cancer Research, American Association for Cancer Research, 2012, 72 (14), pp.3463-3470. ⟨10.1158/0008-5472.CAN-11-4199⟩

Integrins play a role in the resistance of advanced cancers to radiotherapy and chemotherapy. In this study, we show that high expression of the α5 integrin subunit compromises temozolomide-induced tumor suppressor p53 activity in human glioblastoma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a8dd3a4f2607d8802db755053662fbd
https://hal.archives-ouvertes.fr/hal-00746868

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Involvement of the TGFβ pathway in the regulation of α5β1 integrins by caveolin-1 in human glioblastoma

Autor: Sébastien Froelich, Pascal Chastagner, Sophie Pinel, Sophie Martin, Dominique Bonnet, Erika C. Cosset, Monique Dontenwill, Natacha Entz-Werle, Eric Guérin, Julien Godet, Dominique Guenot, François Plénat

Publikováno v: International Journal of Cancer
International Journal of Cancer, Wiley, 2012, 131 (3), pp.601-611. ⟨10.1002/ijc.26415⟩
International Journal of Cancer, Wiley, 2012, 131, pp.601-611

International audience; Caveolin-1 plays a crucial role in the development of cancer and its progression. We previously reported that glioblastoma cells expressing low levels of caveolin-1 exerted a more aggressive phenotype than cells expressing hig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8592fc895bebbe1c70fe50f128a6256e
https://hal.archives-ouvertes.fr/hal-00705319

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Specificities of β1 integrin signaling in the control of cell adhesion and adhesive strength

Autor: Angélique Millon-Frémillon, Myriam Régent, Marc R. Block, Corinne Albiges-Rizo, Eva Faurobert, Daniel Bouvard, Anne-Pascale Bouin, Emmanuelle Planus, Molly Brunner

Publikováno v: Eur J Cell Biol
Eur J Cell Biol, 2010, 90 (2-3), pp.261-9. ⟨10.1016/j.ejcb.2010.09.006⟩

International audience; Cells exert actomyosin contractility and cytoskeleton-dependent force in response to matrix stiffness cues. Cells dynamically adapt to force by modifying their behavior and remodeling their microenvironment. This adaptation is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a967a28bd6cd01bf773db420b1738432
https://www.hal.inserm.fr/inserm-00544923

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Leberagin-C, A disintegrin-like/cysteine-rich protein from Macrovipera lebetina transmediterranea venom, inhibits alphavbeta3 integrin-mediated cell adhesion

Autor: Ines Limam, Olfa Kallech-Ziri, Salma Taboubi, Asma Hammami, José Luis, Jed Jebali, Amine Bazaa, Hafedh Mejdoub, Mohamed El Ayeb, Raoudha Zouari-Kessentini, Najet Srairi-Abid, Naziha Marrakchi

Publikováno v: Matrix Biology
Matrix Biology, Elsevier, 2010, 29 (2), pp.117-26. ⟨10.1016/j.matbio.2009.09.009⟩

International audience; Leberagin-C, a new member of the disintegrin-like/cysteine-rich (D/C) family, was purified to homogeneity from the venom of Tunisian snake Macrovipera lebetina transmediterranea. It is a monomeric protein with a molecular mass

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8427f129741daba1456e25af6f74e81b
https://hal-riip.archives-ouvertes.fr/pasteur-00621003

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Molecular dissection of the ILK-PINCH-parvin triad reveals a fundamental role for the ILK kinase domain in the late stages of focal-adhesion maturation

Autor: Reinhard Fässler, Carine Flore Nguemeni Yonga, Carsten Grashoff, Fabio Stanchi, Ellen Van Obberghen-Schilling, Dominique Grall

Publikováno v: Journal of Cell Science
Journal of Cell Science, Company of Biologists, 2009, 122 (Pt 11), pp.1800-11. ⟨10.1242/jcs.044602⟩

International audience; Integrin-linked kinase (ILK) and cytoplasmic adaptors of the PINCH and parvin families form a ternary complex, termed IPP, that localizes to integrin adhesions. We show here that deletion of the genes encoding ILK or PINCH1 si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ed67775d00d531689bc1ed8343bad1e
https://pubmed.ncbi.nlm.nih.gov/19435803

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MVL-PLA2, a phospholipase A2 from Macrovipera lebetina transmediterranea venom, inhibits tumor cells adhesion and migration

Autor: Raoudha Kessentini-Zouari, José Luis, Jean-Claude Lissitzky, Amine Bazaa, Mohamed El Ayeb, Céline Defilles, Olfa Kallech-Ziri, Najet Srairi-Abid, Naziha Marrakchi

Publikováno v: Matrix Biology
Matrix Biology, Elsevier, 2009, 28 (4), pp.188-93. ⟨10.1016/j.matbio.2009.03.007⟩

Here, we report the purification and characterization of an acidic Asp49 phospholipase A2, named MVL-PLA2, with a molecular mass of 13,626.64 Da. The complete MVL-PLA2 cDNA was cloned from Macrovipera lebetina transmediterranea venom gland cDNA libra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24b040a7152e8fddce3a5ad7f4f3c069
https://hal-riip.archives-ouvertes.fr/pasteur-00612541

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alphaVbeta6 is a novel receptor for human fibrillin-1. Comparative studies of molecular determinants underlying integrin-rgd affinity and specificity

Autor: Jovanovic, J, Takagi, J, Choulier, L, Abrescia, N, Stuart, D, Van Der Merwe, P, Mardon, H, Handford, P

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2007, 282 (9), pp.6743-51. ⟨10.1074/jbc.M607008200⟩

Human fibrillin-1, the major structural protein of connective tissue 10-12 nm microfibrils, contains multiple calcium binding epidermal growth factor-like domains interspersed with transforming growth factor beta-binding protein-like (TB) domains. TB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a5682f6e08ee348189244cbfb7f58d8b
https://hal.archives-ouvertes.fr/hal-00264692

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ILK is required for the assembly of matrix-forming adhesions and capillary morphogenesis in endothelial cells

Autor: Cédric Matthews, Dominique Grall, Etienne Boulter, Valérie Vouret-Craviari, Ellen Van Obberghen-Schilling

Publikováno v: Journal of Cell Science
Journal of Cell Science, Company of Biologists, 2004, 117 (Pt 19), pp.4559-69. ⟨10.1242/jcs.01331⟩

International audience; Integrins play a key role in regulating endothelial cell survival, migration and differentiated function during angiogenic blood-vessel remodeling. Integrin-linked kinase (ILK) is a multidomain protein that interacts with the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b93b212a1eec27e86942ea475a381850
https://pubmed.ncbi.nlm.nih.gov/15316070

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