Corynanthean-Epicatechin Flavoalkaloids from Corynanthe pachyceras

Autor: Kouamé, Tapé, Okpekon, Aboua Timothée, Bony, Nicaise, N'Tamon, Amon Diane, Gallard, Jean-François, Rharrabti, Somia, Leblanc, Karine, Mouray, Elisabeth, Grellier, Philippe, Champy, Pierre, Beniddir, Mehdi, Le Pogam, Pierre, N’tamon, Amon Diane

Publikováno v: Molecules
Molecules, 2020, 25 (11), pp.2654. ⟨10.3390/molecules25112654⟩
Molecules, MDPI, 2020, 25 (11), pp.2654. ⟨10.3390/molecules25112654⟩
Volume 25
Issue 11
Molecules, Vol 25, Iss 2654, p 2654 (2020)

International audience; Epicatechocorynantheines A and B, and epicatechocorynantheidine were isolated from the stem bark of Corynanthe pachyceras. These molecules were pinpointed, and their isolation streamlined, by a molecular networking strategy. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5762dd0fc047468ece605416711231f
https://cnrs.hal.science/hal-04082725

Lipid nanocapsules decorated and loaded with cannabidiol as targeted prolonged release carriers for glioma therapy: In vitro screening of critical parameters

Autor: Victor Sebastian, Jean-Pierre Benoit, Juan Aparicio-Blanco, Ana I. Torres-Suárez

Publikováno v: European Journal of Pharmaceutics and Biopharmaceutics
European Journal of Pharmaceutics and Biopharmaceutics, Elsevier, 2019, 134, pp.126-137. ⟨10.1016/j.ejpb.2018.11.020⟩

International audience; The therapeutic potential of cannabinoids has been truly constrained heretofore due to their strong psychoactive effects and their high lipophilicity. In this context, precisely due to the lack of psychoactive properties, cann

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed21a59c217cc3d27a4511ab36466f9b
https://hal.univ-angers.fr/hal-02490875

Association of Microsatellite Variations of Plasmodium falciparum Na+/H+ Exchanger (Pfnhe-1) Gene with Reduced In Vitro Susceptibility to Quinine: Lack of Confirmation in Clinical Isolates from Africa

Autor: Didier Menard, Christiane Bouchier, Jacques Le Bras, Rémy Durand, Véronique Hubert, Stéphane Rabearimanana, Magali Tichit, Valérie Andriantsoanirina

Publikováno v: American Journal of Tropical Medicine and Hygiene
American Journal of Tropical Medicine and Hygiene, American Society of Tropical Medicine and Hygiene, 2010, 82 (5), pp.782-7. ⟨10.4269/ajtmh.2010.09-0327⟩
American Journal of Tropical Medicine and Hygiene, 2010, 82 (5), pp.782-7. ⟨10.4269/ajtmh.2010.09-0327⟩
The American journal of tropical medicine and hygiene
The American journal of tropical medicine and hygiene, 2010, 82 (5), pp.782-7. 〈10.4269/ajtmh.2010.09-0327〉

International audience; We sought to test the association of polymorphisms in Plasmodium falciparum nhe-1 (Pfnhe-1, gene PF13_0019) with in vitro susceptibility to quinine, which was previously reported in a limited number of reference strains or cul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a6cff6bb8fe77054b0c9e4697568fff
https://doi.org/10.4269/ajtmh.2010.09-0327

Inhibition studies of DNA methyltransferases by maleimide derivatives of RG108 as non-nucleoside inhibitors

Autor: Céline Faux, Johan Wouters, Grégoire Rondelet, Véronique Masson, Paola B. Arimondo, Jean Dubois, Laurence Fleury, Luc Willems

Publikováno v: Future Medicinal Chemistry
Future Medicinal Chemistry, Future Science, 2017, 9 (13), pp.1465-1481. ⟨10.4155/fmc-2017-0074⟩

Aim: DNA methyltransferases (DNMTs) are important drug targets for epigenetic therapy of cancer. Nowadays, non-nucleoside DNMT inhibitors are in development to address high toxicity of nucleoside analogs. However, these compounds still have low activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd20bb0670ff106f4bc18abd08f8abf
https://pubmed.ncbi.nlm.nih.gov/28795598

Novel 1,4-benzodiazepine derivatives with antiproliferative properties on tumor cell lines

Autor: Nohad Gresh, Jennifer Dourlat, Wang-Qing Liu, Christiane Garbay

Publikováno v: Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2007, 17 (9), pp.2527-30. ⟨10.1016/j.bmcl.2007.02.016⟩
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2007, 17 (9), pp.2527-30. 〈10.1016/j.bmcl.2007.02.016〉
Bioorganic and Medicinal Chemistry Letters, 2007, 17 (9), pp.2527-30. ⟨10.1016/j.bmcl.2007.02.016⟩

International audience; Novel 1,4-benzodiazepine compounds were synthesized and evaluated for their ability to inhibit the proliferation of tumor cells. Some compounds revealed activities in the micromolar range and were more efficient than reference

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a012d647d17c694225f9d483c9636c8
https://doi.org/10.1016/j.bmcl.2007.02.016