Výsledky vyhledávání - "MESH: Immunoglobulin Constant Regions"

Can immunoglobulin C(H)1 constant region domain modulate antigen binding affinity of antibodies?

Autor: J. P. Bouvet, Malcolm Buckle, Otto Pritsch, Jean Gagnon, Gilbert Hudry-Clergeon, Guillaume Dighiero, Yves Pétillot

Publikováno v: Journal of Clinical Investigation
Journal of Clinical Investigation, American Society for Clinical Investigation, 1996, 98 (10), pp.2235-43. ⟨10.1172/JCI119033⟩
Journal of Clinical Investigation, 1996, 98 (10), pp.2235-43. ⟨10.1172/JCI119033⟩

Although the switch process is frequently associated with affin- ity maturation, the constant region is not assumed to play a role in Ag-Ab binding. In the present work, we demonstrate that two clonally related human monoclonal Igs sharing iden- tica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd37e99674e848044e496a52987f1f79
https://doi.org/10.1172/jci119033

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Identification of HLA-A2 restricted T-cell epitopes within the conserved region of the immunoglobulin G heavy-chain in patients with multiple myeloma

Autor: Bernd Kasper, Sebastian Belle, Bernard Klein, Peter Terness, Dirk Hose, Marion Moos, Michael Hundemer, Olaf Christensen, Mathias Witzens-Harig, Maud Condomines, Hartmut Goldschmidt, Friedrich W. Cremer, Anthony D. Ho, Fang Han, Christian Kleist

Publikováno v: European Journal of Haematology
European Journal of Haematology, Wiley, 2008, 81 (1), pp.26-35. ⟨10.1111/j.1600-0609.2008.01076.x⟩

Objective: The aim of this study is the identification of HLA-A2 restricted T-cell epitopes in the conserved region of the immunoglobulin-G-heavy-chain (IgGH) that can be used for immunotherapy in multiple myeloma (MM) patients. Methods: After the Ig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2656ad5c29d2641433901929786a5285
https://pubmed.ncbi.nlm.nih.gov/18363871

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Germ-line transcription occurs on both the functional and the non-functional alleles of immunoglobulin constant heavy chain genes

Autor: Marc Le Bert, Michel Cogné, Ahmed Amine Khamlichi, Laurent Delpy

Publikováno v: European Journal of Immunology
European Journal of Immunology, Wiley-VCH Verlag, 2003, 33 (8), pp.2108-13. ⟨10.1002/eji.200323969⟩

In B cells undergoing class switching, recombination is usually directed to the same switch sequences on both homologous chromosomes and is generally preceded by germ-line transcription initiated from I promoters upstream of immunoglobulin constant h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3516604336da1c3824919fd91d036c6f
https://hal.archives-ouvertes.fr/hal-00023385

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Interallelic class switch recombination contributes significantly to class switching in mouse B cells

Autor: Hei-Lanne Dougier, Laurence Fleury, Laurent Delpy, Christophe Sirac, Stéphane Reynaud, Michel Cogné

Publikováno v: Scopus-Elsevier
Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2005, 174, pp.5905-5906
ResearcherID
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2005, 174 (10), pp.6176-83

Except for the expression of IgM and IgD, DNA recombination is constantly needed for the expression of other Ig classes and subclasses. The predominant path of class switch recombination (CSR) is intrachromosomal, and the looping-out and deletion mod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e0c4bb7020bae0bef2e932d9d730a6b
http://www.scopus.com/inward/record.url?eid=2-s2.0-18644380562&partnerID=MN8TOARS

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