Zobrazeno 1 - 10
of 27
pro vyhledávání: '"MESH: Immunoglobulin Class Switching"'
Autor:
Estelle Vincendeau, Wenming Wei, Xuefei Zhang, Cyril Planchais, Wei Yu, Hélène Lenden-Hasse, Thomas Cokelaer, Juliana Pipoli da Fonseca, Hugo Mouquet, David J. Adams, Frederick W. Alt, Stephen P. Jackson, Gabriel Balmus, Chloé Lescale, Ludovic Deriano
Publikováno v:
Nature Communications
Nature Communications, 2022, 13 (1), pp.3707. ⟨10.1038/s41467-022-31287-3⟩
Nature Communications, 2022, 13 (1), pp.3707. ⟨10.1038/s41467-022-31287-3⟩
Funder: Ligue Nationale Contre le Cancer
SHLD1 is part of the Shieldin (SHLD) complex, which acts downstream of 53BP1 to counteract DNA double-strand break (DSB) end resection and promote DNA repair via non-homologous end-joining (NHEJ). While 5
SHLD1 is part of the Shieldin (SHLD) complex, which acts downstream of 53BP1 to counteract DNA double-strand break (DSB) end resection and promote DNA repair via non-homologous end-joining (NHEJ). While 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6552ddce6e8fcc03619460c08b3e7d7a
Autor:
Hugo Mouquet, Grégory Jouvion, Helene Strick-Marchand, Ai Ing Lim, Nicolas Serafini, Zacarias Garcia, Philippe Bousso, Yan Li, Daniela Finke, Olivier Schwartz, Timothée Bruel, Ayrin Kök, Franck Bourgade, Guillemette Masse-Ranson, Thierry Hieu, Antoine Toubert, Mathilde Dusséaux, James P. Di Santo
Publikováno v:
Nature Methods
Nature Methods, Nature Publishing Group, 2018, 15 (8), pp.623-630. ⟨10.1038/s41592-018-0071-6⟩
Nature Methods, 2018, 15 (8), pp.623-630. ⟨10.1038/s41592-018-0071-6⟩
Nature Methods, Nature Publishing Group, 2018, 15 (8), pp.623-630. ⟨10.1038/s41592-018-0071-6⟩
Nature Methods, 2018, 15 (8), pp.623-630. ⟨10.1038/s41592-018-0071-6⟩
International audience; Lymph nodes (LNs) facilitate the cellular interactions that orchestrate immune responses. Human immune system (HIS) mice are powerful tools for interrogation of human immunity but lack secondary lymphoid tissue (SLT) as a resu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::152ed891295814431a971358f8be482b
https://pubmed.ncbi.nlm.nih.gov/30065374
https://pubmed.ncbi.nlm.nih.gov/30065374
Autor:
Heng-Kuan Wong, Françoise Dantzer, Valérie Schreiber, Aurélia Noll, Bernardo Reina-San-Martin, José Yélamos, Léa Gaudot, Isabelle Robert
Publikováno v:
Eur J Immunol
Eur J Immunol, 2017, 47 (4), pp.665-676. ⟨10.1002/eji.201646757⟩
Eur J Immunol, 2017, 47 (4), pp.665-676. ⟨10.1002/eji.201646757⟩
To mount highly specific and adapted immune responses, B lymphocytes assemble and diversify their antibody repertoire through mechanisms involving the formation of programmed DNA damage. Immunoglobulin class switch recombination (CSR) is triggered by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e3a2de51cecef0a8af35091ee7c1401
https://hal.archives-ouvertes.fr/hal-02369971
https://hal.archives-ouvertes.fr/hal-02369971
Autor:
Benoit Arcangioli, Hanen Ouadani, Beya Larguèche, Imen Ben-Mustapha, Hatem Masmoudi, François Rougeon, Houda Elloumi-Zghal, Mohamed-Ridha Barbouche, Tihana Jovanic, Meriem Ben-Ali, Mongia Hachicha, Dahmani M. Fathallah, Sylvie Garcia
Publikováno v:
Molecular Immunology
Molecular Immunology, 2016, 79, pp.77-82. ⟨10.1016/j.molimm.2016.09.025⟩
Molecular Immunology, Elsevier, 2016, 79, pp.77-82. ⟨10.1016/j.molimm.2016.09.025⟩
Molecular Immunology, 2016, 79, pp.77-82. ⟨10.1016/j.molimm.2016.09.025⟩
Molecular Immunology, Elsevier, 2016, 79, pp.77-82. ⟨10.1016/j.molimm.2016.09.025⟩
International audience; Activation induced cytidine deaminase (AID) is an essential enzyme for class switch recombination (CSR) and somatic hypermutation (SHM) during secondary immune response. Mutations in the AICDA gene are responsible for Hyper Ig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d198ff026ab2745225baea1a94295f
https://hal-riip.archives-ouvertes.fr/pasteur-01453058
https://hal-riip.archives-ouvertes.fr/pasteur-01453058
Autor:
Michel Cogné, Véronique Truffinet, Christelle Vincent-Fabert, Yves Denizot, Rémi Fiancette, Nadine Cogné
Publikováno v:
Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2009, 182 (11), pp.6926-32. ⟨10.4049/jimmunol.0900214⟩
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2009, 182 (11), pp.6926-32. ⟨10.4049/jimmunol.0900214⟩
Several studies have reported that regulatory elements located 3′ of the IgH locus (namely hs3a, hs1,2, hs3b, and hs4) might play a role during class switch recombination (CSR) and Ig synthesis. While individual deletion of hs3a or hs1,2 had no eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd8412c9a14d20cc8560da8e50cdb21a
https://doi.org/10.4049/jimmunol.0900214
https://doi.org/10.4049/jimmunol.0900214
Autor:
Tanja A. Schwickert, Kevin M. McBride, Mila Jankovic, Michel C. Nussenzweig, Thomas Eisenreich, Gordon F. Heidkamp, To-Ha Thai, Davide F. Robbiani, Michela Di Virgilio, Yair Dorsett, Bernardo Reina San-Martin, Anna Gazumyan, Klaus Rajewsky
Publikováno v:
Immunity
Immunity, Elsevier, 2008, 28 (5), pp.630-8. ⟨10.1016/j.immuni.2008.04.002⟩
Immunity, 2008, 28 (5), pp.630-8. ⟨10.1016/j.immuni.2008.04.002⟩
Immunity, Elsevier, 2008, 28 (5), pp.630-8. ⟨10.1016/j.immuni.2008.04.002⟩
Immunity, 2008, 28 (5), pp.630-8. ⟨10.1016/j.immuni.2008.04.002⟩
International audience; MicroRNAs (miRNAs) are small noncoding RNAs that regulate vast networks of genes that share miRNA target sequences. To examine the physiologic effects of an individual miRNA-mRNA interaction in vivo, we generated mice that car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9484aee3b6ffa7c023b50153d0ca3b4
Publikováno v:
Nature Reviews Immunology
Nature Reviews Immunology, Nature Publishing Group, 2008, 8 (4), pp.302-12. 〈10.1038/nri2281〉
Nature Reviews Immunology, Nature Publishing Group, 2008, 8 (4), pp.302-12. 〈10.1038/nri2281〉
review article; International audience; To cope with an unpredictable variety of potential pathogenic insults, the immune system must generate an enormous diversity of recognition structures, and it does so by making stepwise modifications at key gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12cc4aed7a5c2ed9f5d3f7950899c4c5
https://doi.org/10.1038/nri2281
https://doi.org/10.1038/nri2281
Autor:
Lili Wang, Michel Cogné, Amy L. Kenter, Fernando Grigera, John P. Manis, Thomas Perlot, Eric Pinaud, Frederick W. Alt, Robert Wuerffel, Erik Selsing
Publikováno v:
Immunity
Immunity, Elsevier, 2007, 27 (5), pp.711-22. ⟨10.1016/j.immuni.2007.09.007⟩
Immunity, Elsevier, 2007, 27 (5), pp.711-22. ⟨10.1016/j.immuni.2007.09.007⟩
International audience; Molecular mechanisms underlying synapsis of activation-induced deaminase (AID)-targeted S regions during class switch recombination (CSR) are poorly understood. By using chromosome conformation capture techniques, we found tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a81ad11f2461cddcb2a25eac4e82a357
Autor:
Sandra Weller, Anne Stary, Claude-Agnès Reynaud, Alain Sarasin, Jean-Claude Weill, Said Aoufouchi, Ahmad Faili, Françoise Vuillier
Publikováno v:
Journal of Experimental Medicine
Journal of Experimental Medicine, 2004, 199 (2), pp.265-70. ⟨10.1084/jem.20031831⟩
Journal of Experimental Medicine, Rockefeller University Press, 2004, 199 (2), pp.265-70. ⟨10.1084/jem.20031831⟩
The Journal of Experimental Medecine
The Journal of Experimental Medecine, The Rockefeller University Press, 2004, 199 (2), pp.265-70. 〈10.1084/jem.20031831〉
The Journal of Experimental Medicine
Journal of Experimental Medicine, 2004, 199 (2), pp.265-70. ⟨10.1084/jem.20031831⟩
Journal of Experimental Medicine, Rockefeller University Press, 2004, 199 (2), pp.265-70. ⟨10.1084/jem.20031831⟩
The Journal of Experimental Medecine
The Journal of Experimental Medecine, The Rockefeller University Press, 2004, 199 (2), pp.265-70. 〈10.1084/jem.20031831〉
The Journal of Experimental Medicine
Base substitutions, deletions, and duplications are observed at the immunoglobulin locus in DNA sequences involved in class switch recombination (CSR). These mutations are dependent upon activation-induced cytidine deaminase (AID) and present all the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43782f0cda1bfdfaf99eb0f99969e78c
https://doi.org/10.1084/jem.20031831
https://doi.org/10.1084/jem.20031831
Publikováno v:
Genes and Immunity
Genes and Immunity, Nature Publishing Group: Open Access Hybrid Model Option B, 2014, 15 (5), pp.341-6. ⟨10.1038/gene.2014.25⟩
Genes and Immunity, Nature Publishing Group: Open Access Hybrid Model Option B, 2014, 15 (5), pp.341-6. ⟨10.1038/gene.2014.25⟩
International audience; Immunoglobulin (Ig) genes specifically recruit activation-induced deaminase (AID) for 'on-target' DNA deamination, initiating either variable (V) region somatic hypermutation, or double-strand break intermediates of class swit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64f7c8160d6a667d91df65432999dfab
https://hal.archives-ouvertes.fr/hal-01112042
https://hal.archives-ouvertes.fr/hal-01112042