Zobrazeno 1 - 10
of 11
pro vyhledávání: '"MESH: Histone Deacetylase Inhibitors"'
Autor:
Manfred Jung, Karin Schmidtkunz, Elizabeth R Morales, Stefan Günther, Wolfgang Sippl, Martin Hügle, Frank Erdmann, Patrik Zeyen, Ehab Ghazy, Dina Robaa, Christophe Romier, Matthias Schmidt, Daniel Herp
Publikováno v:
European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, 2020, 200, pp.112338. ⟨10.1016/j.ejmech.2020.112338⟩
European Journal of Medicinal Chemistry, Elsevier, 2020, 200, pp.112338. ⟨10.1016/j.ejmech.2020.112338⟩
European Journal of Medicinal Chemistry, 2020, 200, pp.112338. ⟨10.1016/j.ejmech.2020.112338⟩
European Journal of Medicinal Chemistry, Elsevier, 2020, 200, pp.112338. ⟨10.1016/j.ejmech.2020.112338⟩
International audience; Histone modifying proteins, specifically histone deacetylases (HDACs) and bromodomains, have emerged as novel promising targets for anticancer therapy. In the current work, based on available crystal structures and docking stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::738621ff6d5b1624d9660f91e10c4ab7
https://hal.science/hal-02999300/document
https://hal.science/hal-02999300/document
Autor:
Awada, Rayan, Verdier, Dorothée, Froger, Solène, Brulard, Eric, de Faria Maraschin, Simone, Etienne, Hervé, Breton, David
Publikováno v:
Scientific Reports
Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.810. ⟨10.1038/s41598-020-57800-6⟩
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports, 2020, 10 (1), pp.810. ⟨10.1038/s41598-020-57800-6⟩
Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.810. ⟨10.1038/s41598-020-57800-6⟩
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports, 2020, 10 (1), pp.810. ⟨10.1038/s41598-020-57800-6⟩
International audience; Somatic embryogenesis (SE) faces many challenges in fulfilling the growing demand for elite materials. A high-throughput approach is required to accelerate the optimization of SE protocols by multiplying experimental condition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ad560625731b76de1f486cba55a1089c
https://hal.umontpellier.fr/hal-03454869
https://hal.umontpellier.fr/hal-03454869
Autor:
Raymond J. Pierce, Wolfgang Sippl, Julien Lancelot, Karin Schmidtkunz, Alokta Chakrabarti, Dina Robaa, Jelena Melesina, Tajith B. Shaik, Christophe Romier, Conrad V. Simoben, Manfred Jung, Srinivasaraghavan Kannan, Martin Marek
Publikováno v:
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules
Molecules, 2018, 23 (3), pp.566. ⟨10.3390/molecules23030566⟩
Molecules, Vol 23, Iss 3, p 566 (2018)
Molecules; Volume 23; Issue 3; Pages: 566
Molecules, MDPI, 2018, 23 (3), pp.566. ⟨10.3390/molecules23030566⟩
Molecules
Molecules, 2018, 23 (3), pp.566. ⟨10.3390/molecules23030566⟩
Molecules, Vol 23, Iss 3, p 566 (2018)
Molecules; Volume 23; Issue 3; Pages: 566
Molecules, MDPI, 2018, 23 (3), pp.566. ⟨10.3390/molecules23030566⟩
International audience; A promising means in the search of new small molecules for the treatment of schistosomiasis (amongst other parasitic ailments) is by targeting the parasitic epigenome. In the present study, a docking based virtual screening pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c57756972e5c4439f4e393638be3994b
http://europepmc.org/articles/PMC6017931
http://europepmc.org/articles/PMC6017931
Autor:
Philippe J. Sansonetti, Emmanuel Sechet, Aurelien Amiot, Brice Sperandio, Natalie Fischer, Robin C. Friedman, Giulia Nigro, Iradj Sobhani
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2016, 113 (21), pp.9. ⟨10.1073/pnas.1605997113⟩
Proceedings of the National Academy of Sciences of the United States of America, 2016, 113 (21), pp.9. ⟨10.1073/pnas.1605997113⟩
International audience; SignificanceAntimicrobial peptides exert antimicrobial, antifungal, antiviral, and antiprotozoan activity. They are expressed at high concentrations at the intestinal mucosal surface, where they play a crucial role in intestin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99a4bb25d00141bbfaec753aad196535
https://hal-pasteur.archives-ouvertes.fr/pasteur-03926939
https://hal-pasteur.archives-ouvertes.fr/pasteur-03926939
Autor:
Brunella Costanza, P Meunier, Philippe Delvenne, Akeila Bellahcene, Vincent Hennequière, Pamela Maris, Sara Rezzola, Ana Palacios, Roberto Ronca, Paul Peixoto, Laurent Schoysman, Andrei Turtoi, Arnaud Blomme, Vincenzo Castronovo, Nicolas Goffart, Elettra Bianchi, Aurélie Henry, Robert N. Muller, Bernard Rogister, Sébastien Boutry, E Di Valentin, Olivier Peulen
Publikováno v:
Oncogene
Oncogene, Nature Publishing Group, 2016, 35 (34), pp.4481-4494. ⟨10.1038/onc.2015.506⟩
Oncogene, Nature Publishing Group, 2016, 35 (34), pp.4481-4494. ⟨10.1038/onc.2015.506⟩
International audience; To date, the mutational status of EGFR and PTEN has been shown as relevant for favoring pro- or anti-tumor functions of STAT3 in human glioblastoma multiforme (GBM). We have screened genomic data from 154 patients and have ide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ff5cb94e95794e8a300c948d8451910
https://pubmed.ncbi.nlm.nih.gov/26853466
https://pubmed.ncbi.nlm.nih.gov/26853466
Autor:
Arthur S. Foutz, Diana M. Escolar, Hafedh Haddad, Morgane Roulot, Vincent Voisin, Catherine Sebrié, Xun He, Hua Yu, Sara Vianello, Sabine De La Porte, Maurice Israël, Brigitte Gillet, Stefan Matecki, Cyrille Vaillend, Françoise Fougerousse, Laura Bossi, Caroline Perronnet
Publikováno v:
FASEB Journal
FASEB Journal, Federation of American Society of Experimental Biology, 2013, 27 (6), pp.2256-69. ⟨10.1096/fj.12-215723⟩
FASEB Journal, Federation of American Society of Experimental Biology, 2013, 27 (6), pp.2256-2269. ⟨10.1096/fj.12-215723⟩
FASEB Journal, 2013, 27 (6), pp.2256-69. ⟨10.1096/fj.12-215723⟩
FASEB Journal, Federation of American Society of Experimental Biology, 2013, 27 (6), pp.2256-69. ⟨10.1096/fj.12-215723⟩
FASEB Journal, Federation of American Society of Experimental Biology, 2013, 27 (6), pp.2256-2269. ⟨10.1096/fj.12-215723⟩
FASEB Journal, 2013, 27 (6), pp.2256-69. ⟨10.1096/fj.12-215723⟩
International audience; As a strategy to treat Duchenne muscular dystrophy, we used arginine butyrate, which combines two pharmacological activities: nitric oxide pathway activation, and histone deacetylase inhibition. Continuous intraperitoneal admi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9ef80cf836e3082d21e555c045138be
https://hal.archives-ouvertes.fr/hal-00850330
https://hal.archives-ouvertes.fr/hal-00850330
Autor:
Jin Wang, Anne Laure Vitte, Xiaodong Xi, Thérèse Rossini, Boubou Diagouraga, Karin Sadoul, Thierry Buchou, Benoît Polack, Saadi Khochbin, Patrick Matthias
Publikováno v:
Blood
Blood, American Society of Hematology, 2012, 120 (20), pp.4215-8. ⟨10.1182/blood-2012-05-428011⟩
Blood, 2012, 120 (20), pp.4215-8. ⟨10.1182/blood-2012-05-428011⟩
Blood, American Society of Hematology, 2012, 120 (20), pp.4215-8. ⟨10.1182/blood-2012-05-428011⟩
Blood, 2012, 120 (20), pp.4215-8. ⟨10.1182/blood-2012-05-428011⟩
HDAC6, a major cytoplasmic deacetylase, is shown here to fine-tune the kinetics of platelet activation, a process that must be precisely regulated to ensure hemostasis after blood vessel injury while preventing pathologic thrombus formation. The disc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66821c5f0a12ee886127aadf2edaf7e4
https://hal.archives-ouvertes.fr/hal-00816897
https://hal.archives-ouvertes.fr/hal-00816897
Autor:
Marc Grégoire, Zinaida Peric, Béatrice Gaugler, Mohamad Mohty, Jihane Frikeche, Eolia Brissot
Publikováno v:
Experimental Hematology
Experimental Hematology, Elsevier, 2012, 40 (10), pp.783-91. ⟨10.1016/j.exphem.2012.06.008⟩
Experimental Hematology, 2012, 40 (10), pp.783-91. ⟨10.1016/j.exphem.2012.06.008⟩
Experimental Hematology, Elsevier, 2012, 40 (10), pp.783-91. ⟨10.1016/j.exphem.2012.06.008⟩
Experimental Hematology, 2012, 40 (10), pp.783-91. ⟨10.1016/j.exphem.2012.06.008⟩
International audience; Histone deacetylase inhibitors are presently used in the routine clinic treatment against cancers. Recent data have established that some of these treatments have potent anti-inflammatory or immunomodulatory effects at noncyto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a018a03ffd4f410f609f37b5ce484b7f
https://www.hal.inserm.fr/inserm-00826919
https://www.hal.inserm.fr/inserm-00826919
Autor:
Baharia Mograbi, Christelle Bonnetaud, Sandra Lassalle, Chimène Moreilhon, Virginie Tanga, Bernard Mari, Patrick Brest, Véronique Hofman, Géraldine Rios, Pascal Barbry, Paul Hofman, Catharina Svanborg, Olivier Bordone, José Santini
Publikováno v:
Endocrine-Related Cancer
Endocrine-Related Cancer, BioScientifica, 2011, 18 (6), pp.711-9. ⟨10.1530/ERC-10-0257⟩
Endocrine Related Cancer; Vol 18
Endocrine-Related Cancer, BioScientifica, 2011, 18 (6), pp.711-9. ⟨10.1530/ERC-10-0257⟩
Endocrine Related Cancer; Vol 18
International audience; The molecular mechanism responsible for the antitumor activity of histone deacetylase inhibitors (HDACi) remains elusive. As HDACi have been described to alter miRNA expression, the aim of this study was to characterize HDACi-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2d28de74526294559f6c32debb5e60a
https://hal.archives-ouvertes.fr/hal-00724345
https://hal.archives-ouvertes.fr/hal-00724345
Autor:
Paola Grazioli, Maria Eugenia Schininà, G Ferrara, Isabella Screpanti, Rocco Palermo, Saula Checquolo, Alessandra Giorgi, Vinod Kumar, Luigi Frati, Alberto Gulino, A Giovenco, Gianluca Canettieri, Maddalena Napolitano, Marella Maroder, Alessandra Vacca, Antonio Francesco Campese
Publikováno v:
Oncogene
Oncogene, Nature Publishing Group, 2012, 31 (33), pp.3807-17. ⟨10.1038/onc.2011.533⟩
Oncogene, Nature Publishing Group, 2012, 31 (33), pp.3807-17. ⟨10.1038/onc.2011.533⟩
International audience; Post-translational modifications of Notch3 and their functional role with respect to Notch3 overexpression in T-cell leukemia are still poorly understood. We identify here a specific novel property of Notch3 that is acetylated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e36614c426438357db5b35f442d296a5
https://pubmed.ncbi.nlm.nih.gov/22120716
https://pubmed.ncbi.nlm.nih.gov/22120716